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|
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|
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|
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Signaling Pathways
Apoptosis
♦
Bcl-2
(
37
)
♦
p53
(
20
)
♦
Caspase
(
25
)
♦
TNFa
(
20
)
♦
Mdm2
(
22
)
♦
c-RET
(
4
)
♦
IAP
(
9
)
♦
PERK
(
4
)
♦
PD-1/PD-L1
(
15
)
♦
Survivin
(
3
)
♦
Apoptosis
(
88
)
♦
RIP kinase
(
18
)
♦
ROS
(
1
)
♦
Cytohesin
(
1
)
♦
Ras
(
3
)
♦
Thymidylate Synthase
(
4
)
♦
DAPK
(
1
)
♦
ASK
(
1
)
♦
FKBP
(
2
)
♦
Ferroptosis
(
9
)
♦
TRADD
(
1
)
♦
PKD
(
3
)
♦
c-Myc
(
2
)
♦
TNF Receptor
(
2
)
PI3K/Akt/mTOR
♦
PI3K
(
108
)
♦
Akt
(
42
)
♦
mTOR
(
31
)
♦
GSK-3
(
24
)
♦
ATM/ATR
(
3
)
♦
PDK-1
(
4
)
♦
S6 kinase
(
6
)
♦
AMPK
(
19
)
♦
DNA-PK
(
10
)
♦
PTEN
(
3
)
♦
PDPK1
(
3
)
♦
NUDIX
(
3
)
♦
PDHK
(
3
)
♦
PI4K
(
5
)
♦
PP2A
(
1
)
♦
MELK
(
4
)
♦
PIKfyve
(
1
)
Epigenetics
♦
HDAC
(
12
)
♦
HIF
(
7
)
♦
PARP
(
0
)
♦
JAK
(
56
)
♦
Aurora Kinase
(
24
)
♦
Histone Acetyltransferase
(
14
)
♦
Histone Demethylase
(
28
)
♦
Histone Methyltransferase
(
87
)
♦
DNA Methyltransferase
(
14
)
♦
Epigenetic Reader Domain
(
72
)
♦
Sirtuin
(
19
)
♦
Pim
(
6
)
♦
PKC
(
17
)
♦
SMYD
(
1
)
♦
MAT
(
5
)
♦
MicroRNA
(
2
)
♦
AMPK
(
6
)
♦
Protein Arginine Deiminase
(
3
)
♦
EZH1/2
(
1
)
♦
MLL
(
1
)
MAPK
♦
MEK
(
32
)
♦
ERK
(
31
)
♦
Raf
(
30
)
♦
JNK
(
22
)
♦
p38 MAPK
(
34
)
♦
RSK
(
5
)
♦
Mixed Lineage Kinase
(
5
)
♦
KLF
(
4
)
♦
MNK
(
4
)
♦
MAP4K
(
4
)
♦
MAP3K
(
2
)
♦
MK2
(
3
)
Protein Tyrosine Kinase
♦
VEGFR
(
80
)
♦
EGFR
(
66
)
♦
PDGFR
(
25
)
♦
c-MET
(
34
)
♦
HER-2
(
2
)
♦
ALK
(
24
)
♦
FLT3
(
17
)
♦
FGFR
(
29
)
♦
IFG-1R
(
11
)
♦
c-Kit
(
10
)
♦
Tie-2
(
1
)
♦
CSF-1R
(
4
)
♦
TAM Receptor
(
10
)
♦
Trk receptor
(
9
)
♦
c-RET
(
0
)
♦
Axl
(
2
)
♦
Bcr-Abl
(
10
)
♦
Ephrin Receptor
(
2
)
♦
Pyk2
(
1
)
♦
c-Fms
(
8
)
♦
DDR
(
1
)
♦
IGF-1R
(
0
)
♦
HER2
(
2
)
♦
Src
(
14
)
♦
Syk
(
10
)
♦
DYRK
(
5
)
♦
FAK
(
5
)
♦
Btk
(
23
)
♦
Itk
(
2
)
♦
Mertk
(
1
)
♦
RET
(
7
)
♦
SHP2
(
5
)
♦
Insulin Receptor
(
3
)
♦
ROS Kinase
(
1
)
♦
BMX Kinase
(
1
)
♦
Discoidin Domain Receptor
(
2
)
Angiogenesis
♦
VEGFR
(
1
)
♦
EGFR
(
1
)
♦
PDGFR
(
0
)
♦
HIF
(
5
)
♦
HER-2
(
1
)
♦
JAK
(
0
)
♦
FLT3
(
2
)
♦
FGFR
(
0
)
♦
BTK
(
14
)
♦
Syk
(
8
)
♦
FAK
(
8
)
♦
Src
(
9
)
♦
Bcr-Abl
(
11
)
♦
VDA
(
3
)
♦
ALK
(
1
)
♦
5-alpha Reductase
(
1
)
Proteases
♦
Proteasome
(
15
)
♦
Cysteine Protease
(
15
)
♦
Serine Protease
(
9
)
♦
Gamma-secretase
(
10
)
♦
HCV Protease
(
12
)
♦
HIV Protease
(
9
)
♦
MMP
(
10
)
♦
DPP-4
(
15
)
♦
Caspase
(
0
)
♦
Acyltransferase
(
1
)
♦
Tyrosinase
(
1
)
♦
Glutaminase
(
8
)
♦
Thrombin
(
8
)
♦
3C-Like Protease
(
1
)
♦
Neprilysin
(
2
)
NF-kB
♦
NOD1
(
2
)
♦
IκB/IKK
(
28
)
♦
NF-κB
(
59
)
♦
HDAC
(
0
)
♦
ROS
(
1
)
♦
Keap1-Nrf2
(
8
)
Autophagy
♦
Autophagy
(
63
)
♦
LRRK2
(
15
)
♦
ULK
(
6
)
♦
Mitophagy
(
1
)
♦
OGA
(
1
)
JAK/STAT
♦
JAK
(
13
)
♦
STAT
(
13
)
♦
EGFR
(
36
)
♦
Pim
(
14
)
Metabolism
♦
PDE
(
38
)
♦
P450 (e.g. CYP)
(
31
)
♦
PPAR
(
22
)
♦
Phospholipase
(
12
)
♦
DHFR
(
8
)
♦
Dehydrogenase
(
33
)
♦
HSP
(
22
)
♦
Carbonic Anhydrase
(
19
)
♦
MAO
(
5
)
♦
FAAH
(
12
)
♦
CETP
(
4
)
♦
Transferase
(
12
)
♦
HMG-CoA Reductase
(
11
)
♦
Hydroxylase
(
9
)
♦
IDO
(
12
)
♦
Retinoid Receptor
(
9
)
♦
Factor Xa
(
5
)
♦
AhR
(
7
)
♦
Ferroptosis
(
4
)
♦
Casein Kinase
(
14
)
♦
NAMPT
(
7
)
♦
Glucosylceramide Synthase
(
2
)
♦
Aldose Reductase
(
2
)
♦
ATP-citrate lyase
(
1
)
♦
Carbohydrate Metabolism
(
3
)
♦
FXR
(
12
)
♦
IAP
(
1
)
♦
Lipoxygenase
(
11
)
♦
Mitochondrial Metabolism
(
3
)
♦
PCSK9
(
4
)
♦
Phosphorylase
(
2
)
♦
Serine hydrolase
(
1
)
♦
SGK
(
2
)
♦
Vitamin
(
15
)
♦
Acyltransferase
(
2
)
♦
CAR
(
2
)
♦
ROR
(
6
)
♦
PRMT
(
2
)
♦
PGC-1α
(
2
)
♦
Lipase
(
3
)
♦
OXPHOS
(
3
)
♦
Peroxidases
(
3
)
♦
Phosphatase
(
6
)
♦
Decarboxylase
(
4
)
♦
Prostaglandin Receptor
(
1
)
♦
Serine/threonin kinase
(
6
)
♦
Fatty Acid Synthase
(
6
)
♦
SCD
(
1
)
♦
THR
(
4
)
♦
Glutathione
(
1
)
♦
CPT
(
2
)
♦
Acetyl-CoA Carboxylase
(
5
)
♦
AChR
(
2
)
♦
cGAS
(
2
)
♦
CPSase
(
1
)
♦
AdipoR
(
2
)
♦
GLUT
(
2
)
♦
PKM
(
3
)
♦
Mitochondrial pyruvate carrier
(
1
)
♦
ACSS2
(
1
)
♦
FABP
(
1
)
♦
Xanthine Oxidase
(
1
)
♦
Thrombopoietin Receptor
(
1
)
♦
Thioredoxin Reductase
(
1
)
♦
SHIP
(
1
)
Neuronal Signaling
♦
5-HT Receptor
(
5
)
♦
COX
(
42
)
♦
GluR
(
24
)
♦
Adrenergic Receptor
(
11
)
♦
AChR Receptor
(
63
)
♦
Histamine Receptor
(
8
)
♦
Dopamine Receptor
(
9
)
♦
Opioid Receptor
(
5
)
♦
GABA Receptor
(
19
)
♦
P-gp
(
0
)
♦
CaMK
(
12
)
♦
P2 Receptor
(
9
)
♦
OX Receptor
(
1
)
♦
MT Receptor
(
0
)
♦
BACE
(
3
)
♦
Gamma-secretase
(
0
)
♦
Beta Amyloid
(
19
)
♦
Monoamine Oxidase
(
13
)
♦
P2Y Receptor
(
1
)
♦
NMDAR
(
7
)
♦
γ-secretase
(
3
)
♦
Calcium Channel
(
6
)
♦
Serotonin Transporter
(
7
)
♦
Transthyretin (TTR)
(
2
)
♦
Notch
(
8
)
♦
ChE
(
10
)
♦
BChE
(
2
)
♦
Glucosylceramide Synthase
(
3
)
♦
AAK1
(
2
)
♦
Dopamine Transporter
(
4
)
♦
Sigma Receptor
(
15
)
♦
Tau Protein
(
1
)
♦
Beta-secretase
(
6
)
♦
Imidazoline Receptor
(
4
)
♦
Adenosine Kinase
(
2
)
♦
α-synuclein
(
1
)
Ubiquitin
♦
E2 conjugating
(
2
)
♦
p97
(
5
)
♦
E3 Ligase
(
11
)
♦
DUB
(
20
)
♦
Proteasome
(
0
)
♦
E1 Activating
(
5
)
♦
SUMO
(
1
)
Stem Cells/Wnt
♦
Hedgehog/Smoothened ROCK
(
5
)
♦
ROCK
(
0
)
♦
Wnt/beta-catenin
(
30
)
♦
Gamma-secretase
(
0
)
♦
Casein Kinase
(
4
)
♦
TGF–beta/Smad
(
1
)
♦
STAT
(
9
)
♦
JAK
(
0
)
♦
GSK-3
(
2
)
♦
Smo
(
5
)
♦
PKA
(
6
)
♦
Oct
(
3
)
♦
Porcupine
(
3
)
♦
Hippo (MST)
(
2
)
♦
YAP
(
5
)
♦
SFRP
(
1
)
♦
Stemness kinase
(
1
)
DNA Damage
♦
Telomerase
(
3
)
♦
Topoisomerase
(
54
)
♦
DNA/RNA Synthesis
(
115
)
♦
HDAC
(
52
)
♦
ATM/ATR
(
18
)
♦
PARP
(
51
)
♦
Sirtuin
(
7
)
♦
DNA Stain
(
4
)
♦
Nucleoside Antimetabolite/Analog
(
7
)
♦
DNA alkylator
(
10
)
♦
p97
(
3
)
♦
CRISPR/Cas9
(
1
)
♦
SMN
(
1
)
♦
HSP
(
11
)
♦
RNR
(
2
)
♦
OGG1
(
2
)
♦
RAD51
(
4
)
♦
PARG
(
1
)
GPCR & G Protein
♦
cAMP
(
8
)
♦
Adenosine Receptor
(
38
)
♦
Vasopressin Receptor
(
8
)
♦
CXCR
(
35
)
♦
CaSR
(
8
)
♦
PAFR
(
2
)
♦
CGRP Receptor
(
6
)
♦
LPA Receptor
(
2
)
♦
SGLT
(
8
)
♦
S1P Receptor
(
12
)
♦
Endothelin Receptor
(
13
)
♦
Cannabinoid Receptor
(
24
)
♦
5-HT Receptor
(
141
)
♦
Adrenergic Receptor
(
113
)
♦
Histamine Receptor
(
76
)
♦
Dopamine Receptor
(
77
)
♦
Opioid Receptor
(
30
)
♦
Hedgehog/Smoothened ROCK
(
11
)
♦
OX Receptor
(
23
)
♦
MT Receptor
(
2
)
♦
Guanylate Cyclase
(
15
)
♦
LPL Receptor
(
18
)
♦
NPY receptor
(
1
)
♦
Angiotensin Receptor
(
21
)
♦
Free Fatty Acid Receptor
(
10
)
♦
GnRH Receptor
(
10
)
♦
GPR
(
21
)
♦
Leukotriene Receptor
(
8
)
♦
mAChR
(
32
)
♦
Neurotensin Receptor
(
4
)
♦
Prostaglandin Receptor
(
40
)
♦
Sigma Receptor
(
1
)
♦
PAR
(
10
)
♦
CCR
(
21
)
♦
GCGR
(
27
)
♦
GHSR
(
6
)
♦
GPCR19
(
3
)
♦
LTR
(
1
)
♦
mGluR
(
29
)
♦
PKD
(
2
)
♦
Ras
(
22
)
♦
CCK receptor
(
4
)
♦
Melatonin Receptor
(
5
)
♦
Formyl Peptide Receptor
(
2
)
♦
G protein-coupled Bile Acid Receptor
(
2
)
♦
Melanocortin Receptor
(
5
)
♦
Neurokinin Receptor
(
12
)
♦
Oxytocin Receptor
(
3
)
♦
Somatostatin Receptor
(
3
)
♦
Adenylate Cyclase
(
3
)
♦
Bradykinin Receptor
(
3
)
♦
P2Y Receptor
(
7
)
♦
Urotensin Receptor
(
1
)
♦
TSH Receptor
(
2
)
♦
PKG
(
2
)
♦
RGS Protein
(
3
)
♦
Glucagon Receptor
(
2
)
♦
TAAR
(
1
)
♦
Neuropeptide Y Receptor
(
5
)
♦
Motilin Receptor
(
1
)
♦
CRFR
(
3
)
♦
APJ
(
1
)
♦
EBI2
(
1
)
♦
Bombesin Receptor
(
2
)
♦
GPR109A
(
2
)
♦
MRGPR
(
2
)
TGF-beta/Smad
♦
MT Receptor
(
20
)
♦
Bcr-Abl
(
0
)
♦
ROCK
(
23
)
♦
PKC
(
16
)
♦
TGF-β Receptor
(
13
)
♦
TGF-beta/Smad
(
6
)
Cell Cycle
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CDK
(
105
)
♦
Rho
(
19
)
♦
PLK
(
19
)
♦
Chk
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12
)
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7
)
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8
)
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5
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1
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3
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5
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0
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5
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4
)
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)
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)
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2
)
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p21
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1
)
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2
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1
)
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10
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1
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0
)
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HSP
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3
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3
)
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4
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28
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26
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6
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2
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5
)
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3
)
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1
)
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(
1
)
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TACC3
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1
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11
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18
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38
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64
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75
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82
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14
)
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CRM1
(
2
)
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0
)
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9
)
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OCT
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0
)
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(
3
)
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3
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6
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3
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2
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42
)
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3
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CD markers
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4
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3
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37
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1
)
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20
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1
)
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9
)
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2
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1
)
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P2X Receptor
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9
)
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3
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4
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2
)
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2
)
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2
)
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NKCC
(
1
)
♦
VDAC
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4
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NHE
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3
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URAT1
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4
)
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2
)
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Na+/Ca2+ Exchanger
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2
)
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1
)
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1
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2
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27
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9
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3
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10
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31
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9
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33
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36
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4
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1
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2
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1
)
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6
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11
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7
)
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8
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3
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13
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1
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2
)
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4
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5
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1
)
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1
)
ADC Related
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5
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2
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12
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2
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5
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6
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5
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5
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1
)
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6
)
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5
)
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28
)
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8
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1
)
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4
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3
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6
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7
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5
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1
)
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2
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1
)
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5
)
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9
)
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2
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8
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6
)
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11
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1
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6
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5
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5
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2
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2
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3
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1
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2
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3
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1
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2
)
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4
)
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3
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2
)
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1
)
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2
)
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1
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5
)
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3
)
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2
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8
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5
)
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1
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4
)
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1
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2
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1
)
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1
)
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1
)
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1
)
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1
)
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1
)
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1
)
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1
)
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8
)
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45
)
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34
)
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272
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16
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5
)
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29
)
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1
)
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43
)
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16
)
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(
4
)
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3
)
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(
19
)
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(
2
)
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(
3
)
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1
)
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(
1
)
♦
HCV
(
0
)
♦
Enterovirus
(
6
)
♦
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(
26
)
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(
3
)
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♦
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(
8
)
♦
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(
2
)
♦
ERR
(
30
)
♦
Thyroid Hormone Receptor
(
6
)
♦
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(
14
)
♦
VD/VDR
(
19
)
PROTAC
♦
PROTAC Linkers
(
44
)
♦
E3 Ligase Ligand-Linker Conjugates
(
7
)
♦
Ligands for E3 Ligase
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11
)
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(
2
)
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1
)
♦
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2
)
Unfolded Protein Response
♦
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(
4
)
♦
IRE1
(
8
)
♦
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(
1
)
♦
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(
2
)
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1
)
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54
)
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50
)
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3
)
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1
)
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1
)
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1
)
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421
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2018
)
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Fine Intermediates/Building Blocks
Others
Mc-GGFG-OH
Catalog No：
V2208
CAS No. (CAS Registry Number)：
2413428-36-9
Price：
$0/g
Description: Mc-GGFG-OH is a bifunctional linker used in the synthesis of ADC (antibody drug conjuate). Mc-GGFG-OH contains a carboxy group, which can react with amino group or hydroxy group after act...
TST-A
Catalog No：
V2228
CAS No. (CAS Registry Number)：
1426953-21-0
Price：
$0/g
Description: TST-A , also known as Thailanstatin A, is a potent antiproliferative agent, which was isolated from the fermentation broth of B. thailandensis MSMB43
MC-Gly-Gly-Phe
Catalog No：
V2286
CAS No. (CAS Registry Number)：
1599440-15-9
Price：
$0/g
Description: MC-Gly-Gly-Phe is a novel linker commonly used in the synthesis of antibody-drug conjugates (ADC) in which it connects the antibody with the drug-load.References: Antibody...
Boc-Dap-NE
Catalog No：
V2288
CAS No. (CAS Registry Number)：
160800-65-7
Price：
$0/g
Description: Boc-Dap-NE is a kind of dipeptide and it is a cleavable ADC linker. Boc-Dap-NE is used in the synthesis of antibody-drug conjugates (ADCs).
Val-Lys(Boc)-PAB
Catalog No：
V2314
CAS No. (CAS Registry Number)：
1432969-86-2
Price：
$0/g
Description: Val-Lys(Boc)-PAB is a novel ADC linker which was used to prepare camptothecin peptide conjugates as antitumor agents (WO 2019195665).
Fmoc-Phe-Lys(Boc)-PAB
Catalog No：
V2318
CAS No. (CAS Registry Number)：
206133-42-8
Price：
$0/g
Description: Fmoc-Phe-Lys(Boc)-PAB is a novel ADC linker used in the synthesis of antibody-drug conjugates (ADC).
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