Hedgehog/Smoothened ROCK

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Signaling Pathways
Apoptosis
- ♦ Bcl-2(14)
- ♦ p53(11)
- ♦ Caspase(12)
- ♦ TNFa(12)
- ♦ Mdm2(17)
- ♦ c-RET(4)
- ♦ IAP(6)
- ♦ PERK(4)
- ♦ PD-1/PD-L1(15)
- ♦ Survivin(1)
- ♦ Apoptosis(1)
PI3K/Akt/mTOR
- ♦ PI3K (64)
- ♦ Akt (22)
- ♦ mTOR (21)
- ♦ GSK-3 (17)
- ♦ ATM/ATR (0)
- ♦ PDK-1 (4)
- ♦ S6 kinase (6)
- ♦ AMPK (8)
- ♦ DNA-PK (3)
Epigenetics
- ♦ HDAC(3)
- ♦ HIF(7)
- ♦ PARP(0)
- ♦ JAK(33)
- ♦ Aurora Kinase(23)
- ♦ Histone Acetyltransferase (6)
- ♦ Histone Demethylase(10)
- ♦ Histone Methyltransferase (29)
- ♦ DNA Methyltransferase(8)
- ♦ Epigenetic Reader Domain (19)
- ♦ Sirtuin (11)
- ♦ Pim (6)
MAPK
- ♦ MEK(18)
- ♦ ERK(9)
- ♦ Raf(16)
- ♦ JNK(9)
- ♦ p38 MAPK(17)
Protein Tyrosine Kinase
- ♦ VEGFR (46)
- ♦ EGFR (42)
- ♦ PDGFR(12)
- ♦ c-MET (15)
- ♦ HER-2(2)
- ♦ ALK(10)
- ♦ FLT3 (8)
- ♦ FGFR (10)
- ♦ IFG-1R(8)
- ♦ c-Kit(3)
- ♦ Tie-2(1)
- ♦ CSF-1R(2)
- ♦ TAM Receptor (6)
- ♦ Trk receptor(3)
- ♦ c-RET(0)
Angiogenesis
- ♦ VEGFR (1)
- ♦ EGFR (0)
- ♦ PDGFR (0)
- ♦ HIF (1)
- ♦ HER-2 (0)
- ♦ JAK (0)
- ♦ FLT3 (0)
- ♦ FGFR (0)
- ♦ BTK (8)
- ♦ Syk(6)
- ♦ FAK (8)
- ♦ Src (8)
- ♦ Bcr-Abl (10)
- ♦ VDA (3)
Proteases
- ♦ Proteasome (13)
- ♦ Cysteine Protease (11)
- ♦ Serine Protease(6)
- ♦ Gamma-secretase (10)
- ♦ HCV Protease (5)
- ♦ HIV Protease(7)
- ♦ MMP (6)
- ♦ DPP-4 (8)
- ♦ Caspase (0)
- ♦ Acyltransferase(1)
NF-kB
- ♦ NOD1 (2)
- ♦ IκB/IKK(15)
- ♦ NF-κB(15)
- ♦ HDAC (0)
Autophagy
- ♦ Autophagy (24)
- ♦ LRRK2 (6)
JAK/STAT
- ♦ JAK (1)
- ♦ STAT(0)
- ♦ EGFR (3)
- ♦ Pim (1)
Metabolism
- ♦ PDE (26)
- ♦ P450 (e.g. CYP) (25)
- ♦ PPAR (16)
- ♦ Phospholipase (8)
- ♦ DHFR(6)
- ♦ Dehydrogenase (19)
- ♦ HSP (20)
- ♦ Carbonic Anhydrase (16)
- ♦ MAO (0)
- ♦ FAAH (6)
- ♦ CETP(4)
- ♦ Transferase (8)
- ♦ HMG-CoA Reductase(11)
- ♦ Hydroxylase (8)
- ♦ IDO (6)
- ♦ Retinoid Receptor (5)
- ♦ Factor Xa (4)
- ♦ AhR (3)
- ♦ Ferroptosis(3)
- ♦ Casein Kinase (4)
- ♦ NAMPT (3)
- ♦ Glucosylceramide Synthase(1)
Neuronal Signaling
- ♦ 5-HT Receptor (1)
- ♦ COX (40)
- ♦ GluR (19)
- ♦ Adrenergic Receptor(1)
- ♦ AChR Receptor (56)
- ♦ Histamine Receptor (0)
- ♦ Dopamine Receptor (1)
- ♦ Opioid Receptor (0)
- ♦ GABA Receptor (3)
- ♦ P-gp (0)
- ♦ CaMK (8)
- ♦ P2 Receptor (7)
- ♦ OX Receptor (0)
- ♦ MT Receptor (0)
- ♦ BACE (2)
- ♦ Gamma-secretase (0)
- ♦ Beta Amyloid (5)
- ♦ Monoamine Oxidase(1)
Ubiquitin
- ♦ E2 conjugating (1)
- ♦ p97 (3)
- ♦ E3 Ligase (0)
- ♦ DUB (9)
- ♦ Proteasome (0)
Stem Cells/Wnt
- ♦ Hedgehog/Smoothened ROCK (1)
- ♦ ROCK(0)
- ♦ Wnt/beta-catenin (2)
- ♦ Gamma-secretase (0)
- ♦ Casein Kinase (1)
- ♦ TGF–beta/Smad (0)
- ♦ STAT (9)
- ♦ JAK (0)
- ♦ GSK-3 (0)
DNA Damage
- ♦ Telomerase(2)
- ♦ Topoisomerase (36)
- ♦ DNA/RNA Synthesis (74)
- ♦ HDAC (39)
- ♦ ATM/ATR (14)
- ♦ PARP (31)
- ♦ Sirtuin (0)
- ♦ DNA Stain(1)
GPCR & G Protein
- ♦ cAMP (2)
- ♦ Adenosine Receptor (19)
- ♦ Vasopressin Receptor (5)
- ♦ CXCR (7)
- ♦ CaSR (3)
- ♦ PAFR (2)
- ♦ CGRP Receptor (1)
- ♦ LPA Receptor (2)
- ♦ SGLT (5)
- ♦ S1P Receptor (8)
- ♦ Endothelin Receptor (7)
- ♦ Cannabinoid Receptor (9)
- ♦ 5-HT Receptor (79)
- ♦ Adrenergic Receptor (65)
- ♦ Histamine Receptor (47)
- ♦ Dopamine Receptor (39)
- ♦ Opioid Receptor (13)
- ♦ Hedgehog/Smoothened ROCK (11)
- ♦ OX Receptor (8)
- ♦ MT Receptor (2)
- ♦ Guanylate Cyclase(3)
- ♦ LPL Receptor(1)
- ♦ NPY receptor(1)
TGF-beta/Smad
- ♦ MT Receptor (20)
- ♦ Bcr-Abl (0)
- ♦ ROCK (20)
- ♦ PKC (10)
Cell Cycle
- ♦ CDK (45)
- ♦ Rho (13)
- ♦ PLK (10)
- ♦ Chk (6)
- ♦ Aurora Kinase (0)
- ♦ ROCK (2)
- ♦ PD-1/PD-L1 (0)
- ♦ c-Myc (3)
- ♦ Wee1 (1)
- ♦ APC (1)
- ♦ HSP(2)
Cytoskeletal Signaling
- ♦ Bcr-Abl(1)
- ♦ Wnt/beta-catenin (10)
- ♦ PKC (1)
- ♦ FAK(0)
- ♦ HSP (1)
- ♦ Dynamin (3)
- ♦ PAK (4)
- ♦ Integrin (9)
- ♦ Microtubule Associated(25)
- ♦ Kinesin (6)
Transmembrane
- ♦ P-gp (6)
- ♦ Proton Pump (10)
- ♦ GABA Receptor (11)
- ♦ Sodium Channel (28)
- ♦ Potassium Channel (16)
- ♦ Calcium Channel (34)
- ♦ ATPase (0)
- ♦ CRM1 (1)
- ♦ TRPV (0)
- ♦ CFTR (0)
- ♦ OCT (0)
- ♦ Amino Acid Transporter(2)
- ♦ Monocarboxylate Transporter(1)
Endocrinology & Hormones
- ♦ Opioid Receptor (0)
- ♦ Glucocorticoid Receptor(5)
- ♦ Estrogen/progestogen Receptor (43)
- ♦ Androgen Receptor (15)
- ♦ RAAS (27)
- ♦ Aromatase(5)
- ♦ GPR(8)
- ♦ 5-alpha Reductase (2)
Microbiology
- ♦ HCV Protease (1)
- ♦ HIV Protease (0)
- ♦ CCR (1)
- ♦ Reverse Transcriptase(27)
- ♦ Integrase (0)
- ♦ Bacterial(4)
- ♦ Anti-infection(0)
Others
- ♦ gp120/CD4 (2)
- ♦ FXR(4)
- ♦ PKA (2)
- ♦ Thrombin (4)
- ♦ Liver X receptor (3)
- ♦ IL Receptor (0)
- ♦ Others 1(365)
- ♦ Others 2(433)
- ♦ Others 3(331)
- ♦ Others 4(295)
- ♦ Others 5(250)
- ♦ Others 6(572)
- ♦ Others 7(232)
New Products
- ♦ New1(25335)
- ♦ New2(7404)
- ♦ New3(9983)
- ♦ New4(21)
Immunology/Inflammation
- ♦ STING(3)
- ♦ Glucocorticoid Receptor(1)
- ♦ Arginase(2)
- ♦ TLR(3)
ADC Related
- ♦ ADC Linker(3)
Metabolic Enzyme/Protease
- ♦ Phosphodiesterase(PDE)(4)
- ♦ Aminopeptidase(1)
- ♦ Endogenous Metabolite(2)
- ♦ Phospholipase(1)
Anti-infection
- ♦ HSV(1)
- ♦ Fungal(7)
- ♦ Influenza Virus(3)
- ♦ Bacterial(39)
- ♦ HBV(1)
- ♦ HCV Protease(1)
- ♦ HIV(3)
- ♦ RABV(1)
- ♦ Parasite(3)
Vitamin D Related/Nuclear Receptor
- ♦ Progesterone Receptor(1)
- ♦ Glucocorticoid Receptor(2)
- ♦ Estrogen Receptor/ERR(1)
PROTAC
- ♦ PROTAC Linkers(40)
Transmembrane Transporters
- ♦ TRP(1)
- ♦ ATPase(2)

Product Type
Natural Products
- ♦ Natural Products 1(446)
Peptides
- ♦ Peptides 1(1995)
Antibodies
Amino Acids
- ♦ Amino Acids 1(389)
PROTACs
- ♦ PROTACs 1(39)
Fine Intermediates/Building Blocks
Others

Vismodegib (GDC-0449)

Catalog No： V1331

CAS No. (CAS Registry Number)： 879085-55-9

Price： $0/g

Description: Vismodegib (formerly known as GDC-0449; RG-3616; GDC0449; RG3616; trade name: Erivedge) is a potent, orally bioavailable, first-in-class and specific hedgehog pathway inhibitor with ...

Cyclopamine (11-Deoxojervine)

Catalog No： V1332

CAS No. (CAS Registry Number)： 4449-51-8

Price： $0/g

Description: Cyclopamine (formerly HSDB3505; HSDB-3505; 11-deoxojervine), a naturally occuring steroid alkaloid found in Veratrum plant, is reported to be a potent and specific inhibitor of Hedge...

LDE225 (NVP-LDE225,Erismodegib)

Catalog No： V1333

CAS No. (CAS Registry Number)： 956697-53-3 (free base)

Price： $0/g

Description: Erismodegib (formerly LDE-225; NVP LDE-225; LDE225; NVP-LDE22; Sonidegib; trade name of Odomzo) is an orally bioavailable small-molecule antagonist of the Sm...

Taladegib (LY2940680)

Catalog No： V1334

CAS No. (CAS Registry Number)： 1258861-20-9

Price： $0/g

Description: Taladegib (formerly LY2940680, LY 2940680, LY-2940680) is a potent and orally bioavailable Hedgehog pathway antagonist of the smoothened receptor being developed by Eli Lilly fo...

Purmorphamine

Catalog No： V1335

CAS No. (CAS Registry Number)： 483367-10-8

Price： $0/g

Description: Purmorphamine (also called Shh Signaling Antagonist VI) is a potent purine-based agonist of the hedgehog signaling pathway-smoothened receptor with an EC50 of 1 μM. It migh...

PF-5274857

Catalog No： V1336

CAS No. (CAS Registry Number)： 1373615-35-0

Price： $0/g

Description: PF-5274857 (PF5274857; PF 5274857) is a novel, potent, orally bioavailable and selective Smoothened (Smo) antagonist with potential antineoplastic activity. It inhibits Hedgehog (Hh)...

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