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Indocyanine Green

别名: Cardio-Green Fox IR-125 IR 125 IR125 吲哚菁绿;吲哚氰绿;靛氰绿, IR-125;吲哚菁绿, 染料含量;吲哚菁绿INDOCYANINEGREE;吲哚菁绿(靛氰绿);福氏绿;心脏绿;靛氰绿;Indocyanine Green 靛氰绿
目录号: V11684 纯度: =98.24%
COA 产品数据 产品说明书 SDS
Indocyanine Green（IC Green；Cardiogreen；Fox）是一种无毒的三碳花青/荧光染料，用于诊断肝功能测试并确定血容量和心输出量。
Indocyanine Green CAS号: 3599-32-4
产品类别: Fluorescent Dye
产品仅用于科学研究，不针对患者销售
规格 价格 库存 数量
10 mM * 1 mL in DMSO
5mg
10mg
50mg
100mg
250mg
500mg
1g
Other Sizes
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纯度/质量控制文件

纯度: =98.24%

COA
MSDS
NMR
HPLC
产品说明书
产品描述
吲哚菁绿（IC Green；Cardiogreen；Fox）是一种无毒的三碳花青/荧光染料，用于诊断肝功能测试并确定肝血流量和心输出量,以及用于眼科血管造影。吲哚菁绿具有813nm的发射波长（Em）和785nm的激发波长（Ex）。
生物活性&实验参考方法
靶点
Fluorescent dye
体外研究 (In Vitro)
通过浓度为 1000 μg/mL 的吲哚菁绿 (Foxgreen)-光动力疗法 (ICG-PDT)，HGF 细胞中 BAX 的表达显着升高。另一方面，BCL-2基因Impact表达并未受到激光照射或ICG的显着影响。
体内研究 (In Vivo)
体内染色示例1
吲哚菁绿是一种无毒/低毒的荧光染料，可用于检测口服给药后多糖纳米乳液的分布
方法：用于多糖纳米乳液的分布检测
1.将吲哚菁绿溶解在多糖水溶液中，然后加入到纳米乳液中以形成络合物（吲哚菁绿在两种溶液中的最终浓度均为0.05mg/mL）
2.将9只BALB/C裸鼠分为三个实验组。小鼠在各自治疗后禁食4小时，然后置于活体成像设备（Lumina XR Series III；Perkin-Elmer，Inc）中以观察体内荧光分布。
细胞实验
细胞染色示例1
吲哚菁绿是一种无毒/低毒的荧光染料。它只能在静脉注射后被肝细胞吸收，然后由肝细胞分泌。当用无血清培养基培养时，肝细胞吸收吲哚菁绿，细胞质呈绿色。血清恢复后，吲哚青绿从细胞质中分泌出来
方法：用于吲哚菁绿吸收测定
1.将吲哚菁绿以1mg/mL的终浓度加入无血清肝细胞培养基中，在37℃下培养细胞1小时
2.去除无血清培养基，并用PBS洗涤细胞三次
3.用显微镜（IX71FL，OLYMPUS）对细胞进行检查和成像
细胞染色示例2
吲哚菁绿是一种无毒/低毒的荧光染料。它可以被淋巴吸收，并在动物模型和人类受试者中使用其单光子荧光为可视化淋巴管管腔提供对比度
方法：无创2PF成像。
动物实验
体内染色实例 1
吲哚菁绿是一种无毒/低毒的荧光染料，可用于检测口服给药后多糖纳米乳剂的分布。
方法：用于检测多糖纳米乳剂的分布。
1. 将吲哚菁绿溶解于多糖水溶液中，然后加入纳米乳剂中形成复合物（两种溶液中吲哚菁绿的最终浓度均为 0.05 mg/mL）。
2. 将 9 只 BALB/c 裸鼠随机分为三组，每组 1 只。小鼠在分别给药后禁食 4 小时，然后置于活体成像仪（Lumina XR Series III；Perkin-Elmer 公司）中观察体内荧光分布。
药代性质 (ADME/PK)
吸收、分布和排泄
静脉注射后，吲哚菁绿迅速与血浆蛋白结合，经肝脏快速从循环中清除，并以非结合形式经胆汁排泄。
研究表明，大鼠对吲哚菁绿的最大胆汁排泄率（0.065 mg/kg/min）高于兔（0.05 mg/kg/min）或犬（0.027 mg/kg/min）。
半衰期随剂量增加而延长。
……在清除时间方面，普通杂种犬和纯种比格犬之间存在显著差异。
在剂量高于 1 mg/kg 时，大鼠肝脏对吲哚菁绿的表观提取率出奇地低。肝血流量的变化不会改变清除率。
有关吲哚菁绿（共 10 项）的更多吸收、分布和排泄（完整）数据，请访问 HSDB 记录页面。
代谢/代谢物
……吲哚菁绿……以原形出现在胆汁中
毒性/毒理 (Toxicokinetics/TK)
妊娠期和哺乳期影响
◉ 哺乳期用药概述
一位患者的数据显示，低剂量皮下注射吲哚菁绿在母乳中检测不到。目前尚无较大剂量静脉注射的数据。在获得更多数据之前，哺乳期妇女应谨慎使用吲哚菁绿，尤其是在哺乳新生儿或早产儿时。
◉ 对母乳喂养婴儿的影响
截至修订日期，未找到相关的已发表信息。
◉ 对哺乳和母乳的影响
截至修订日期，未找到相关的已发表信息。
药物相互作用
某些药物预处理后，已观察到肝脏排泄功能增强。例如，苯巴比妥已被证实可增加吲哚菁绿的血浆清除率和胆汁排泄量。
用SKF 525-A预处理抑制吲哚菁绿的胆汁分泌，已被证实是由于其温度效应而非对肝内质网的影响。
吲哚菁绿可使大鼠肝细胞对乌本苷的初始摄取率降低50%以上。数据表明，CMPD 可能通过类似于主动载体介导转运的过程进入肝细胞。
在静脉注射 1.0 mg/kg 汞的雄性大鼠中，吲哚菁绿抑制了甲基汞的胆汁排泄。
有关吲哚菁绿的更多相互作用（完整）数据（共 13 项），请访问 HSDB 记录页面。
参考文献

[1]. Effect of photodynamic therapy based on indocyanine green on expression of apoptosis-related genes in human gingival fibroblast cells. Photodiagnosis Photodyn Ther. 2017 Apr 21.
其他信息
吲哚菁绿是一种菁染料，属于苯并吲哚类化合物，也是一种1,1-二取代烷基磺酸盐。
吲哚菁绿是一种无毒的荧光三碳菁染料，其光谱吸收峰值位于790 nm，可用于测定心输出量、肝功能、肝血流量以及眼科血管造影。给药后，吲哚菁绿（ICG）迅速与其主要载体——血浆蛋白结合，从而被限制在血管腔内。该药物的半衰期为150至180秒，主要通过肝脏代谢，经胆汁排出体外。此外，由于摄取率低，ICG 不适用于肾脏、肺、脑脊髓或外周组织的血管造影或功能输出分析。
一种三碳菁染料，用于肝功能检查的诊断，以及测定血容量和心输出量。
另见：吲哚菁绿酸形式（具有活性部分）。
治疗用途
染料
用于测定心输出量、肝功能和肝血流量。对于肝功能研究，将计算量的诊断剂注射到手臂静脉。注射 20 分钟后，从对侧手臂抽取 6 毫升静脉血。凝固和离心后，用光度计在 800-810 nm 处读取澄清血清的吸光度。
健康受试者的染料保留率低于 4%。……如果血清中染料浓度超过 4%，则表明染料无法清除，提示肝功能受损。
通常，静脉注射，测定血容量时，每毫升含 5 毫克染料；测定肝功能时，每公斤体重 0-5 毫克染料。
染料在血浆和全血中稳定，便于后续分析。不同使用者对染料浓度和剂量均有不同要求。人体总剂量通常低于 2 毫克/公斤体重。
药物警告
……本品含有少量（5%）碘化钠；因此，对碘化物过敏的患者应谨慎使用。使用本品后至少 1 周内不应进行放射性碘摄取研究。由于丙磺舒已被证明会影响犬的肝脏摄取，因此应注意这种可能性。
尚未确定本品在妊娠期使用的安全性。
请仅按照推荐使用新鲜配制的溶液。
*注: 文献方法仅供参考, InvivoChem并未独立验证这些方法的准确性
化学信息 & 存储运输条件
分子式
C43H47N2NAO6S2
分子量
774.9629
精确质量
774.277
元素分析
C, 66.64; H, 6.11; N, 3.61; Na, 2.97; O, 12.39; S, 8.27
CAS号
3599-32-4
PubChem CID
5282412
外观&性状
Light green to dark green solid powder
沸点
157ºC
熔点
235 °C
LogP
10.555
tPSA
137.41
氢键供体(HBD)数目
0
氢键受体(HBA)数目
7
可旋转键数目(RBC)
12
重原子数目
54
分子复杂度/Complexity
1520
定义原子立体中心数目
0
SMILES
S(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]1C2C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C3C=2C(C([H])([H])[H])(C([H])([H])[H])C=1/C(/[H])=C(/[H])\C(\[H])=C(/[H])\C(\[H])=C(/[H])\C(\[H])=C1/C(C([H])([H])[H])(C([H])([H])[H])C2C3=C([H])C([H])=C([H])C([H])=C3C([H])=C([H])C=2N/1C([H])([H])C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)[O-])(=O)(=O)[O-].[Na+]
InChi Key
MOFVSTNWEDAEEK-UHFFFAOYSA-M
InChi Code
InChI=1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51)/q+1/p-1
化学名
sodium 4-(2-((1E,3E,5E,7E)-7-(1,1-dimethyl-3-(4-sulfonatobutyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate
别名
Cardio-Green Fox IR-125 IR 125 IR125
HS Tariff Code
2934.99.9001
存储方式

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

注意： 请将本产品存放在密封且受保护的环境中，避免吸湿/受潮和光照。
运输条件
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
溶解度数据
溶解度 (体外实验)
DMSO : ~83.33 mg/mL (~107.53 mM)
H2O : ~5 mg/mL (~6.45 mM)
溶解度 (体内实验)
配方 1 中的溶解度: ≥ 2.5 mg/mL (3.23 mM) (饱和度未知) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液。
例如，若需制备1 mL的工作液，可将100 μL 25.0 mg/mL澄清DMSO储备液加入到400 μL PEG300中，混匀；然后向上述溶液中加入50 μL Tween-80，混匀；加入450 μL生理盐水定容至1 mL。
*生理盐水的制备：将 0.9 g 氯化钠溶解在 100 mL ddH₂O中，得到澄清溶液。
配方 2 中的溶解度: 2.5 mg/mL (3.23 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (这些助溶剂从左到右依次添加，逐一添加), 悬浊液; 超声助溶。
例如，若需制备1 mL的工作液，可将 100 μL 25.0 mg/mL澄清DMSO储备液加入900 μL 20% SBE-β-CD生理盐水溶液中，混匀。
*20% SBE-β-CD 生理盐水溶液的制备（4°C，1 周）：将 2 g SBE-β-CD 溶解于 10 mL 生理盐水中，得到澄清溶液。
请根据您的实验动物和给药方式选择适当的溶解配方/方案：
1、请先配制澄清的储备液(如：用DMSO配置50 或 100 mg/mL母液(储备液));
2、取适量母液，按从左到右的顺序依次添加助溶剂，澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明，并不一定代表此产品 的实际溶解配方):
10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline);
假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀/澄清；向上述体系中加入50 μL Tween-80，混合均匀/澄清；然后继续加入450 μL ddH2O (或 saline)定容至 1 mL；
3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例;
4、 如产品在配制过程中出现沉淀/析出，可通过加热(≤50℃)或超声的方式助溶;
5、为保证最佳实验结果，工作液请现配现用！
6、如不确定怎么将母液配置成体内动物实验的工作液，请查看说明书或联系我们;
7、 以上所有助溶剂都可在 Invivochem.cn网站购买。
制备储备液 1 mg 5 mg 10 mg
1 mM 1.2904 mL 6.4519 mL 12.9039 mL
5 mM 0.2581 mL 1.2904 mL 2.5808 mL
10 mM 0.1290 mL 0.6452 mL 1.2904 mL

1、根据实验需要选择合适的溶剂配制储备液 (母液)：对于大多数产品，InvivoChem推荐用DMSO配置母液 (比如：5、10、20mM或者10、20、50 mg/mL浓度），个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;

2、如果您找不到您想要的溶解度信息，或者很难将产品溶解在溶液中，请联系我们;

3、建议使用下列计算器进行相关计算（摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等）;

4、母液配好之后，将其分装到常规用量，并储存在-20°C或-80°C，尽量减少反复冻融循环。

计算器
计算 重置

摩尔浓度计算器可计算特定溶液所需的质量、体积/浓度，具体如下：

  • 计算制备已知体积和浓度的溶液所需的化合物的质量
  • 计算将已知质量的化合物溶解到所需浓度所需的溶液体积
  • 计算特定体积中已知质量的化合物产生的溶液的浓度
使用摩尔浓度计算器计算摩尔浓度的示例如下所示：
假如化合物的分子量为350.26 g/mol，在5mL DMSO中制备10mM储备液所需的化合物的质量是多少？
  • 在分子量（MW）框中输入350.26
  • 在“浓度”框中输入10，然后选择正确的单位（mM）
  • 在“体积”框中输入5，然后选择正确的单位（mL）
  • 单击“计算”按钮
  • 答案17.513 mg出现在“质量”框中。以类似的方式，您可以计算体积和浓度。
计算 重置

稀释计算器可计算如何稀释已知浓度的储备液。例如，可以输入C1、C2和V2来计算V1，具体如下：

制备25毫升25μM溶液需要多少体积的10 mM储备溶液？
使用方程式C1V1=C2V2，其中C1=10mM，C2=25μM，V2=25 ml，V1未知：
  • 在C1框中输入10，然后选择正确的单位（mM）
  • 在C2框中输入25，然后选择正确的单位（μM）
  • 在V2框中输入25，然后选择正确的单位（mL）
  • 单击“计算”按钮
  • 答案62.5μL（0.1 ml）出现在V1框中
g/mol
计算 重置

分子量计算器可计算化合物的分子量 (摩尔质量)和元素组成，具体如下：

注：化学分子式大小写敏感：C12H18N3O4  c12h18n3o4
计算化合物摩尔质量（分子量）的说明：
  • 要计算化合物的分子量 (摩尔质量)，请输入化学/分子式，然后单击“计算”按钮。
分子质量、分子量、摩尔质量和摩尔量的定义：
  • 分子质量（或分子量）是一种物质的一个分子的质量，用统一的原子质量单位（u）表示。（1u等于碳-12中一个原子质量的1/12）
  • 摩尔质量（摩尔重量）是一摩尔物质的质量，以g/mol表示。
/
计算 重置

配液计算器可计算将特定质量的产品配成特定浓度所需的溶剂体积 (配液体积)

  • 输入试剂的质量、所需的配液浓度以及正确的单位
  • 单击“计算”按钮
  • 答案显示在体积框中
动物体内实验配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
第二步：请输入动物体内配方组成（配方适用于不溶/难溶于水的化合物），不同的产品和批次配方组成不同，如对配方有疑问，可先联系我们提供正确的体内实验配方。此外，请注意这只是一个配方计算器，而不是特定产品的确切配方。
+
+
+
计算 重置

计算结果:

工作液浓度： mg/mL；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度，请首先与我们联系。

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。

(1) 请确保溶液澄清之后，再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶；
            (2) 一定要按顺序加入溶剂 (助溶剂) 。

临床试验信息
PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients with High-Risk Endometrial Cancer
CTID: NCT01737619
Phase: N/A    Status: Active, not recruiting
Date: 2024-11-18
A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer
CTID: NCT06327490
Phase: Phase 2    Status: Recruiting
Date: 2024-11-14
Intraoperative Evaluation of Axillary Lymphatics
CTID: NCT05094102
Phase: N/A    Status: Completed
Date: 2024-11-13
Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)
CTID: NCT05197530
Phase: Phase 1    Status: Recruiting
Date: 2024-11-12
Indocyanine Green Fluoroscopy and SPY Angiography for the Assessment of Lymphatic Structure in Breast Cancer Patients at Risk for Breast Cancer-Related Lymphedema
CTID: NCT06672224
Phase: N/A    Status: Not yet recruiting
Date: 2024-11-04
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The Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery.
CTID: NCT06002906
Phase: Phase 4    Status: Recruiting
Date: 2024-10-26

Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage I Non-small Cell Lung Cancer or Lung Metastases, REPLACING Study
CTID: NCT04987281
Phase: Phase 2    Status: Withdrawn
Date: 2024-10-23
Efficacy of ICG-based NIR Imaging in Intralesional Curettage of Giant Cell Tumors of Bone in Limbs: a Prospective, Single-center, Single-arm, Open Study
CTID: NCT06647901
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-10-18
Impact of Intraoperative ICG on Functional Outc in RARP
CTID: NCT06446648
PhaseEarly Phase 1    Status: Recruiting
Date: 2024-10-15
TumorGlow Intraoperative Molecular Imaging (IMI)
CTID: NCT04723810
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-10-15
Using Indocyanine Green (ICG) to Outline Biliary Tree During Laparoscopic Cholecystectomy
CTID: NCT06629415
Phase: Phase 4    Status: Completed
Date: 2024-10-08
NIFR Image-guided Surgery for Malignant Soft Tissue Tumor With Low-dose SWIG Technique
CTID: NCT06610071
Phase: Phase 1    Status: Not yet recruiting
Date: 2024-09-24
SLN Mapping and ICG Dye for Vulvar Cancer
CTID: NCT06035068
Phase:    Status: Not yet recruiting
Date: 2024-09-19
Magnetic Sentinel Lymph Node Mapping in Gastric Cancer
CTID: NCT05038098
Phase: Phase 1    Status: Not yet recruiting
Date: 2024-09-19
Optimal Dosing of IC-Green for Visualization of Rotator Cuff Vascularity Using Advanced Imaging Modality Arthroscopy
CTID: NCT04340752
Phase: Phase 1    Status: Recruiting
Date: 2024-09-19
Indocyanine Green (ICG) Guided Tumor Resection
CTID: NCT04084067
Phase: Phase 1    Status: Recruiting
Date: 2024-08-28
Permanence of Indocyanine Green in Axillary Lymph Nodes 3 Weeks After Subdermal Injection in Patients With Breast Cancer and Metastatic Lymph Nodes
CTID: NCT06347354
Phase: N/A    Status: Not yet recruiting
Date: 2024-08-27
Intraoperative Tumor Margin Identification With ICG Dye Imaging
CTID: NCT04752137
Phase: Phase 2    Status: Recruiting
Date: 2024-08-06
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
CTID: NCT05645523
PhaseEarly Phase 1    Status: Recruiting
Date: 2024-07-24
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
CTID: NCT05646316
Phase: Phase 3    Status: Recruiting
Date: 2024-07-15
Parathyroid Vascularization During Total Thyroidectomy Using Indocyanine Green Angiography
CTID: NCT05328076
Phase:    Status: Terminated
Date: 2024-07-05
Advanced Gastrointestinal Endoscopic Imaging
CTID: NCT01034670
Phase: N/A    Status: Terminated
Date: 2024-06-26
Detection and Delineation of Necrotizing Fasciitis Via a Vascular Perfusion Fluorophore
CTID: NCT04839302
Phase:    Status: Recruiting
Date: 2024-06-20
Study Evaluating Near-infrared Imaging Coupled With Indocyanine Green for Intraoperative Control of Resection Margins in ENT Surgery
CTID: NCT04842162
Phase: Phase 2    Status: Recruiting
Date: 2024-05-24
Micro-dosing Indocyanine Green (ICG) in Children
CTID: NCT06421103
Phase: N/A    Status: Recruiting
Date: 2024-05-20
Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma
CTID: NCT03941756
Phase: N/A    Status: Recruiting
Date: 2024-05-16
Utility of ICG in Benign Bone Tumors
CTID: NCT05075889
PhaseEarly Phase 1    Status: Completed
Date: 2024-05-14
A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy.
CTID: NCT06024213
Phase:    Status: Completed
Date: 2024-05-10
The Preoperative Administration of ICG Improves Tumor Detection in Patients Undergoing Minimally Invasive Hepatic Resection Guided by Conventional Intraoperative Ultrasound.
CTID: NCT06398028
Phase: Phase 4    Status: Recruiting
Date: 2024-05-03
The Effect of Chemoradiotherapy on Gastric Perfusion in Patients With Gastric Cancer.
CTID: NCT05354856
Phase: Phase 4    Status: Terminated
Date: 2024-05-02
Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation
CTID: NCT06169735
Phase: Phase 4    Status: Recruiting
Date: 2024-04-17
Injection of 99mTc-nanocolloid and ICG to Identify, Retrieve and Qualify TDLN in Early-stage NSCLC
CTID: NCT05555199
Phase: N/A    Status: Recruiting
Date: 2024-04-17
Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging
CTID: NCT02478138
Phase: N/A    Status: Completed
Date: 2024-04-15
Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Thyroidectomy
CTID: NCT05117853
Phase: Phase 3    Status: Recruiting
Date: 2024-04-05
Near-infrared Imaging With Indocyanine Green for Detection of Peritoneal Metastases for Gastric Adenocarcinoma.
CTID: NCT05687617
Phase: Phase 2    Status: Terminated
Date: 2024-04-02
ICG-fluorescence Imaging for Intraoperative Breast Cancer Margins Evaluation: a Dose-timing Study
CTID: NCT06227338
Phase: N/A    Status: Recruiting
Date: 2024-03-29
Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome
CTID: NCT06325618
Phase:    Status: Recruiting
Date: 2024-03-22
ICG Anastomosis Control in Colon Surgery
CTID: NCT05981937
Phase:    Status: Completed
Date: 2024-03-18
Feasibility of Use of Indocyanine Green in Pediatric Colorectal Surgery
CTID: NCT04904081
Phase: Phase 3    Status: Recruiting
Date: 2024-03-15
Accuracy of Sentinel Lymph Node Biopsy in Nodal Staging of High Risk Endometrial Cancer
CTID: NCT01886066
Phase: N/A    Status: Completed
Date: 2024-03-15
Evaluation of Neuroma Perfusion With Indocyanine Green Fluorescence Angiography
CTID: NCT06164392
Phase: Phase 4    Status: Enrolling by invitation
Date: 2024-03-13
Fluorescence Cholangiography During Cholecystectomy - a RCT
CTID: NCT02344654
Phase: N/A    Status: Completed
Date: 2024-02-28
Ultrasound Guided Inguinal Indocyanine Green Injection to Identify and Pre-emptively Seal Lymphatic Leaks
CTID: NCT06258486
Phase: Phase 4    Status: Not yet recruiting
Date: 2024-02-26
ICG Anastomotic Control in Digestive System Surgery
CTID: NCT06270745
Phase:    Status: Recruiting
Date: 2024-02-23
Fluorescence-based Detection of Inflammation and Necrosis to Inform Surgical Decision-making and Enhance Outcomes
CTID: NCT05593523
Phase:    Status: Recruiting
Date: 2024-01-31
Synapse 3D With Intravascular Indocyanine Green
CTID: NCT03953144
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-01-18
Near-Infrared Fluorescence Guided Robotic Pulmonary Segmentectomy for Early Stage Lung Cancer
CTID: NCT02570815
Phase: Phase 1    Status: Recruiting
Date: 2024-01-18
------------------
Thoracic duct identification with indocyanine green fluorescence during esophagectomy
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2021-05-25
The bilateral sentinel node detection rate of fluorescent indocyanine green compared to 99mTc and blue dye in the sentinel node procedure in stage I-IIA cervical cancer
CTID: null
Phase: Phase 4    Status: Trial now transitioned
Date: 2021-03-25
Near-infrared fluorescence imaging using indocyanine green as an adjunct to improve standard-of-care sentinel lymph node procedure in pediatric patients with melanoma or sarcoma of head/neck/trunk, paratesticular or extremities: a feasibility trial
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2020-05-14
Thoracic duct identification with Indocyanine green fluorescence during minimally invasive esophagectomy with patient in prone position
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2020-03-25
‘A pilot study to assess the safety and feasibility of fluorescent sentinel lymph node identification in colon carcinoma using Indocyanine green’
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2020-03-23
SEntinel Lymph node in EarLY ovarian cancer: the SELLY protocol
CTID: null
Phase: Phase 2    Status: Completed
Date: 2020-03-19
Determination of Parathyroid Function by Fluorescence With Indocyanine Green (ICG) After Total Thyroidectomy
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2020-03-05
Study evaluating near infrared imaging coupled with indocyanine green for
CTID: null
Phase: Phase 2    Status: Trial now transitioned
Date: 2020-02-15
Phase II Safety and Efficacy of personalized lymphadenectomy or guided by Indocyanine Green (IGC) vs extended pelvic lymph node dissection in patients diagnosed with Prostate Cancer subsidiaries of Radical Prostatectomy and lymphadenectomy
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2020-01-08
Bronchoscopic indocyanine green fluorescence imaging for the evaluation
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2018-05-17
Sentinel node in ovarian cáncer: tailoring clinical feasibility
CTID: null
Phase: Phase 2    Status: Completed
Date: 2018-01-23
Determining the role of pre-existing factors, early diagnostic options and
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2017-09-15
Assessment of the feasibility and clinical efficacy of the ICG - 99mTc - nanocolloid for sentinel lymph node biopsy
CTID: null
Phase: Phase 2, Phase 3    Status: Ongoing
Date: 2016-09-13
Clinical, operating, prospective, academy, study of not inferiority of the
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2016-05-19
Advanced imaging in laparoscopic HIPEC for peritoneal carcinomatosis of colorectal orgin to improve cytoreduction; a feasibility study
CTID: null
Phase: Phase 3    Status: Completed
Date: 2016-03-30
The occlusion pressure of superficial lymphatics in the upper extremity of healthy volunteers: A Near infrared lymphofluoroscopy approach
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2015-07-08
Sentinel lymph node identification in colon cancer using a radioactive and fluorescent tracer
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2015-01-15
Near-Infrared fluorescence imaging during neck dissection in head and neck cancer patients after peritumoral injection of Indocyanine Green (a feasibility study)
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2014-10-20
Study of the (intravenously injected) ICG (Indocyanine Green) imaging of tumoral implants in patients with peritoneal carcinomatosis from colorectal origin.
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2014-10-13
Study evaluating breast cancer tumorectomy guided by Near-Infrared imaging after the intravenous injection of free Indocyanine Green
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2014-10-06
Pilot clinical trial phase I / IIa to determine condition, low dose and effectiveness of liver function tests (Hepatotest)
CTID: null
Phase: Phase 1, Phase 2    Status: Ongoing
Date: 2014-07-16
Study of the (intravenously injected) Indocyanine Green distribution in the margins of breast cancer after tumorectomy
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2014-01-30
Bronchoscopic indocyanine green fluorescence imaging for the evaluation of tracheal perfusion after surgery
CTID: null
Phase: Phase 2    Status: Completed
Date: 2014-01-24
Influence of Body Mass Index on the identification rate of indocyanine green (ICG) fluorescence mapping for sentinel lymph node detection in early breast cancer
CTID: null
Phase: Phase 4    Status: Completed
Date: 2014-01-24
Near infrared imaging and measurement of extremity lymphatic collector function using indocyanine green
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2014-01-17
Optical images for monitoring treatment changes in rheumatoid arthritis – a longitudinal study with Rheumascan
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2013-12-18
The intraoperative use of fluorescent tracers and multimodal imaging techniques in treatment of head and neck cancer
CTID: null
Phase: Phase 2    Status: Completed
Date: 2013-10-21
Evaluation of the benefit of lymphofluoroscopy in the validation of the manual drainage techniques on lymphedema
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2013-09-30
PILOT TRIAL FOR THE EVALUATION OF HEPATOTEST IN PREOPERATIVE ASSESSMENT IN LIVER FUNCTION.
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2013-08-29
Evaluation of Near-Infra-Red Imaging after peri-areolar and subcutaneous injections of ICG in comparison with the lymphoscintigraphic technique using intra-mammary and peri-tumoral injection of 99mTc-HSA-Nanocolloids for the SLN detection in breast cancer patients.
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2013-08-09
Feasibility study of the (intravenously injected) ICG imaging of tumoral implants in patients with peritoneal carcinomatosis from colorectal cancer
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2013-03-20
Feasibility study of the (intravenously injected) Indocyanine green (ICG) imaging of tumoral implants in patients with peritoneal carcinomatosis from ovarian carcinoma
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2013-03-08
Lymphatic mapping in oropharyngeal neoplasms: comparison between Dynamic Lymphoscintigrafy and Fluorescence Lymphografy using indocyanine green dye (ICG). Validation study.
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2012-09-19
Prospective feasibility study for the evaluation of indocyanine green and near-infrared imaging in sentinel lymph node biopsy for cutaneous melanoma patients: The 'RED-GREEN-BLUE' melanoma study.
CTID: null
Phase: Phase 2    Status: Completed
Date: 2012-07-05
Validation of the use of lymphography with green indocyanine in identifying the sentinel node in breast cancer
CTID: null
Phase: Phase 2    Status: Completed
Date: 2012-06-18
Determination of the sensitivity of ICG fluorescence technique for the detection of Sentinel Lymph Nodes in breast cancer – a monocenter, prospective open-label clinical trial
CTID: null
Phase: Phase 2    Status: Completed
Date: 2011-10-24
Micro-biological and clinical evaluation of the results after adjuvanter laser therapy with 810nm diode laser in frame the parodontologic basis therapy
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2010-05-06
A feasibility study of indocyanine green (ICG) fluorescence mapping for sentinel lymph node detection in early breast cancer
CTID: null
Phase: Phase 2    Status: Completed
Date: 2010-02-02
Prospective, randomized, controlled, mono-centric, two-armed, single-blinded pilot study for the treatment of venous and capillary vascular malformations by Indocyanine Green-augmented laser therapy
CTID: null
Phase: Phase 2    Status: Completed
Date: 2009-05-29
Utilizzo intraoperatorio del verde indocianina-pulsion quale test predittivo di insufficienza epatica dopo resezione epatica maggiore
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2007-04-05
A pilot study to assess the safety of the ICG angiography for the evaluation of lymph duct morphology and function before and after pelvic lymphadenectomy in patients with gynecologic cancers.
CTID: jRCTs031200114
Phase:    Status: Recruiting
Date: 2020-09-10
Evaluation of the intestinal lymph flow using the ICG fluorescence method
CTID: jRCTs061190012
Phase:    Status: Recruiting
Date: 2019-07-25
Visualization of lymphatic malformation
CTID: jRCTs041190036
Phase:    Status: Recruiting
Date: 2019-06-04
Lymph flow in colorectal cancers using real-time ICG imaging
CTID: UMIN000036764
Phase:    Status: Recruiting
Date: 2019-05-20
Indocyanine green and infrared fluorescence in sentinel lymph node mapping for endometrial cancer and cervical cancer: An exploratory study
CTID: jRCTs031180426
Phase:    Status: Complete
Date: 2019-03-25
Efficacy of sentinel node biopsy in oral cancer using 3D-CT lymphography and an indocyanine green frluorsecence guidance
CTID: jRCTs051180087
Phase:    Status: Recruiting
Date: 2019-03-04
NIR fluorescence imaging during staging laparoscopy for detecting metastases in pancreatic cancer
CTID: jRCT1051180076
Phase:    Status: Recruiting
Date: 2019-02-26
Subtotal integumentectomy for treatment of malignant melanoma with indocyanine green(ICG)
CTID: UMIN000035972
Phase: Phase I,II    Status: Recruiting
Date: 2019-02-22
ICG urology
CTID: jRCTs041180038
Phase:    Status: Complete
Date: 2019-02-05
Near-infrared imaging using intravenous indocyanine green to locate pulmonary metastases
CTID: jRCTs051180044
Phase:    Status: Complete
Date: 2019-01-31
Prospective study for feasibility of monitoring renal blood flow in robot assisted partial nephrectomy
CTID: UMIN000033921
Phase:    Status: Complete: follow-up complete
Date: 2018-09-01
The anatomical variations of lower limb lymph vessels by indocyanine green fluorescence lymphography in analysis of healthy volunteers
CTID: UMIN000033553
PhaseNot applicable    Status: Complete: follow-up complete
Date: 2018-08-01
Clinical validation of indcyanine-green(ICG) fluorescence making in endoscopic esophagus/gastric cancer surgery.
CTID: UMIN000033085
Phase:    Status: Recruiting
Date: 2018-06-21
Clinical validation of the gastrointestinal blood flow in the anastomotic part during laparoscopic esophagus/gastric cancer surgery
CTID: UMIN000033087
Phase:    Status: Recruiting
Date: 2018-06-21
A Pilot Study of Indocyanine Green based Fluorescence Imaging in Locally Advanced Rectal Cancer and Metastatic Lateral Lymph Nodes
CTID: UMIN000032986
Phase:    Status: Recruiting
Date: 2018-06-15
Efficacy of lymph flow navigation surgery with infrared ray electronic endoscopy by local injection of Indocyanine Green in gastroenterological cancer
CTID: jRCTs051180001
Phase:    Status: Recruiting
Date: 2018-06-12
Randomized phase 3 trial evaluating the efficacy of ICG fluorescence imaging on anastomotic leakage in laparoscopic surgery of rectal cancer.
CTID: UMIN000030240
Phase:    Status: Complete: follow-up continuing
Date: 2018-04-01
Indocyanine green fluorescence lymphatic node mapping for gastric cancer
CTID: UMIN000031546
Phase:    Status: Pending
Date: 2018-04-01
Study of Indocyanine green for gastrectomy
CTID: UMIN000030978
Phase:    Status: Pending
Date: 2018-03-01
Evaluation of fluorescence imaging with indocyanine green during hepatectomy
CTID: UMIN000031054
Phase:    Status: Complete: follow-up complete
Date: 2018-02-08
Study for safety and usefulness of thoracoscopic segmentectomy using infrared thoracoscope with indocyanine green(ICG)
CTID: UMIN000030911
Phase:    Status: Pending
Date: 2018-02-01
Efficacy of lymph flow navigation surgery with infrared ray electronic endoscopy by local injection of Indocyanine Green in gastroenterological cancer
CTID: UMIN000030906
PhaseNot applicable    Status: Pending
Date: 2018-01-22
Evaluation of intestinal blood flow around the rectosigmoid junction using ICG fluorescence method for the patients with colorectal cancer
CTID: UMIN000030798
PhaseNot applicable    Status: Recruiting
Date: 2018-01-15
Exploratory clinical study of lymphatic and blood flow evaluation by indocyanine-green fluorescence imaging in esophageal cancer operation
CTID: UMIN000030165
Phase:    Status: Pending
Date: 2018-01-01
An Exploratory Clinical Study for The Development of the Diagnostic Method for Lymphatic-vessel Lesions Using Photoacoustic Imaging
CTID: UMIN000030500
Phase:    Status: Complete: follow-up complete
Date: 2017-12-25
Intraoperative indocyanine green in general thoracic surgery
CTID: UMIN000030486
Phase: Phase I,II    Status: Recruiting
Date: 2017-12-24
Fluorescence-enhanced robot-assisted surgery using indocyanine green
CTID: UMIN000029728
Phase:    Status: Pending
Date: 2017-12-01
Efficacy of fluorescence navigation surgery for laparoscopic liver resection
CTID: UMIN000029864
Phase:    Status: Recruiting
Date: 2017-12-01
Evaluation of the intestinal blood flow using Indocyanine green(ICG)fluorescence method in abdominal emergency surgery
CTID: UMIN000029870
Phase:    Status: Recruiting
Date: 2017-11-08
Evaluation of colorectal anastomotic perfusion by intra-operative transanal ICG infrared fluorescence imaging
CTID: UMIN000029555
Phase:    Status: Complete: follow-up complete
Date: 2017-10-19
Applications of fluorescense imaging to HPB surgeries
CTID: UMIN000024238
Phase:    Status: Pending
Date: 2017-10-01
Feasibility study of sentinel lymph node biopsy guided by indocyanine green fluorescence imaging for colon cancer
CTID: UMIN000029159
Phase:    Status: Recruiting
Date: 2017-10-01
Evaluation of anastomotic blood flow after rectal resection using the ICG fluorescence method
CTID: UMIN000028516
Phase:    Status: Recruiting
Date: 2017-09-01
Difference of bile duct visualization by timing of indocyanine green injection in fluorescent imaging on laparoscopic cholecystectomy
CTID: UMIN000028661
Phase:    Status: Complete: follow-up complete
Date: 2017-08-15
The efficacy of navigation surgery using indocyanine green for visualizing bile duct
CTID: UMIN000028549
Phase:    Status: Recruiting
Date: 2017-08-05
Visual evaluation of blood flow in meniscus and ligament
CTID: UMIN000027830
Phase:    Status: Recruiting
Date: 2017-08-01
Prospective study on the effectiveness assessment of Indocyanine Green Lymphography and Lymphatic Surgery for lymphedema and lymphatic disease.
CTID: UMIN000027759
Phase:    Status: Complete: follow-up complete
Date: 2017-07-01
Resarch about near-infraed spectroscopy monitoring
CTID: UMIN000027932
PhaseNot applicable    Status: Recruiting
Date: 2017-06-28
Confirmation of lymphatic system with indocyanine green
CTID: UMIN000027878
Phase:    Status: Complete: follow-up complete
Date: 2017-06-22
Confirmation of pulmonary intersegment with indocyanine green
CTID: UMIN000027877
Phase:    Status: Complete: follow-up complete
Date: 2017-06-22
A clinical role of staging laparoscopy with contrast-enhanced intraoperative ultrasonography and indocyanine green fluorescent imaging for pancreatic ductal adenocarcinoma
CTID: UMIN000026937
Phase:    Status: Complete: follow-up complete
Date: 2017-04-12
A pilot study of indocyanine green fluorescein imaging of the gastric conduit during esophagectomy
CTID: UMIN000026861
Phase:    Status: Complete: follow-up complete
Date: 2017-04-05
Evaluation of the intestinal lymph flow and blood flow using Indocyanine green(ICG)fluorescence method in a colorectal surgery
CTID: UMIN000026728
PhaseNot applicable    Status: Recruiting
Date: 2017-03-29
Indocyanine-assisted pulmonary metastasectomy
CTID: UMIN000026120
Phase: Phase I,II    Status: Recruiting
Date: 2017-03-01
Prospective study on the effectiveness assessment of Indocyanine Green Lymphography and Lymphatic Surgery for lymphedema and lymphatic disease.
CTID: UMIN000025891
Phase: Phase I    Status: Complete: follow-up complete
Date: 2017-02-01
Clinical trial of thoracoscopic segmentectomy using infrared thoracoscopy with indocyanine green
CTID: UMIN000025333
Phase:    Status: Complete: follow-up complete
Date: 2017-01-01
Trial to monitor percutaneous oxygen saturation in autologous tissue transplantation
CTID: UMIN000025197
Phase:    Status:
Date: 2016-12-09
Sentinel lymph node detection in gynecologic cancer
CTID: UMIN000024607
Phase:    Status: Complete: follow-up complete
Date: 2016-12-01
Indocyanine green and infrared fluorescence in sentinel lymph node mapping for endometrial cancer and cervical cancer: An exploratory study
CTID: UMIN000024636
Phase:    Status: Recruiting
Date: 2016-11-01
Tumor identification using fluorescence imaging: comparison of two imaging systems
CTID: UMIN000023993
Phase:    Status: Complete: follow-up complete
Date: 2016-09-18
Near-infrared fluorescence guided pulmonary segmentectomy following transbronchial indocyanine green injection using navigational bronchoscopy
CTID: UMIN000023984
Phase:    Status: Complete: follow-up complete
Date: 2016-09-08
Visual assessment of blood flow in the the acetabular labrum.
CTID: UMIN000023826
Phase:    Status: Recruiting
Date: 2016-08-29
Evaluation of anastomotic blood flow in colorectal surgery using the ICG fluorescence method
CTID: UMIN000022876
PhaseNot applicable    Status: Complete: follow-up complete
Date: 2016-07-15
Prospective study on the effectiveness assessment of Indocyanine Green Lymphography and Lymphatic Surgery for lymphedema and lymphatic disease.
CTID: UMIN000022973
Phase: Phase I    Status: Complete: follow-up complete
Date: 2016-07-01
Assessment of the convection of lymphatic vessel in extremities by indocyanine green (ICG) lypmphography
CTID: UMIN000022780
PhaseNot applicable    Status: Recruiting
Date: 2016-06-20
Indocyanine green (ICG) application to intraoperative navigation of fluorescence imaging
CTID: UMIN000021898
PhaseNot applicable    Status:
Date: 2016-04-15
Clinical validation of intraoperative indcyanine-green(ICG) fluorescence imaging in hepatecomy.
CTID: UMIN000021834
Phase:    Status: Complete: follow-up complete
Date: 2016-04-11
Prospective study on the effectiveness assessment of Indocyanine Green Lymphography and Lymphatic Surgery for lymphedema and lymphatic disease.
CTID: UMIN000021764
Phase: Phase I    Status: Complete: follow-up complete
Date: 2016-04-04
Prospective study on the effectiveness assessment of Indocyanine Green Lymphography and Lymphatic Surgery for lymphedema and lymphatic disease.
CTID: UMIN000021762
Phase: Phase I    Status: Complete: follow-up complete
Date: 2016-04-03
Clinical research for evaluation of organ blood flow by using the ICG fluorescence method during esophagus cancer operations.
CTID: UMIN000021575
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