| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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| 体外研究 (In Vitro) |
2-苯乙醇可激活肥皂中的防腐剂和香烟添加剂[1]。 2. 苯乙醇抑制革兰氏阴性染料的生长[1]。
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|---|---|
| 体内研究 (In Vivo) |
在小鼠中，2-苯基乙醇（5%；呼吸）可减少抑郁样行为并增强焦虑样行为 [3]。
小鼠吸入2-苯乙醇后，在悬尾试验中不动时间减少，提示具有抗抑郁样效应。然而，在旷场试验中，小鼠在中心区域停留时间减少，提示焦虑样行为增加。认知功能、活动水平、肌肉力量或攻击性未观察到变化。 在高架十字迷宫中，与对照组相比，进入开放臂的次数百分比和在开放臂停留时间无显著差异。 在Y迷宫试验中，空间工作记忆无显著差异。 在蔗糖偏好试验中，蔗糖消耗量无变化，提示对快感缺乏样行为无影响。 在Porsolt强迫游泳试验中，不动时间与对照组相比无显著差异。 |
| 动物实验 |
Animal/Disease Models: 11weeks old male mice (C57BL/6) [3]
Doses: 5% (v/v) Route of Administration: inhalation; Experimental Results:It exerts an antidepressant-like effect, but may increase anxiety-like behaviors. Male C57BL/6 mice (11 weeks old) were used. 2-phenylethanol was diluted to 5% (v/v) in 1% Tween 80 and impregnated into absorbent cotton placed in a sealed container. Mice were exposed to 2-PE vapor for 15 minutes in a three-layer cage system before behavioral tests. Control mice were exposed to 1% Tween 80 only. Behavioral tests included: odor preference test, elevated plus maze, open field test, Y-maze test, tail suspension test, Porsolt forced swim test, sucrose preference test, grip strength test, and cotton bud biting test. All tests were performed during the light phase, with at least one day between tests. Apparatus was cleaned with 70% ethanol and super-oxidized hypochlorous acid between trials. |
| 药代性质 (ADME/PK) |
Metabolism / Metabolites
2-PHENYLETHANOL YIELDS PHENYLACETYLALDEHYDE IN RABBITS: SMITH JM ET AL, BIOCHEM J, 56, 320, 1954. /FROM TABLE/ Phenylethyl alcohol is oxidized almost entirely to the corresponding acid. Metabolites excreted in urine following oral doses of 0.2 to 0.3 g/kg to rabbits were phenaceturic acid, the glycine conjugate of phenylacetic acid, 42%; glucosidurinic acid, 5%; and an ether-soluble acid, probably phenylacetic acid, 19%. Only 66% of the original dose could be accounted for. /Phenylethyl alcohol/ ... beta-Phenylethyl alcohol is a substrate for ADH, with an initial rate of oxidation nearly as high as that of allyl alcohol and appreciably greater than that of ethanol. |
| 毒性/毒理 (Toxicokinetics/TK) |
Toxicity Data
LC50 (rat) > 500 mg/m3 Non-Human Toxicity Values LD50 Mouse oral 0.8-1.5 g/kg LD50 Guinea pig oral 0.4-0.8 g/kg LD50 Rat oral 1.79 and 2.46 g/kg LD50 Mouse ip injection 0.4-0.8 g/kg For more Non-Human Toxicity Values (Complete) data for 2-PHENYLETHANOL (7 total), please visit the HSDB record page. |
| 参考文献 | |
| 其他信息 |
2-phenylethanol is a primary alcohol that is ethanol substituted by a phenyl group at position 2. It has a role as a fragrance, a Saccharomyces cerevisiae metabolite, a plant metabolite, an Aspergillus metabolite and a plant growth retardant. It is a primary alcohol and a member of benzenes.
An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery. 2-Phenylethanol has been reported in Francisella tularensis, Camellia sinensis, and other organisms with data available. 2-phenylethanol is a metabolite found in or produced by Saccharomyces cerevisiae. An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery. See also: Moringa oleifera leaf oil (part of). Therapeutic Uses Anti-Infective Agents, Local; Disinfectants; Preservatives, Pharmaceutical Phenylethyl alcohol ... has been used in 0.5% conc as an antibacterial agent in ophthalmic solutions. /Phenylethyl alcohol/ 2-phenylethanol is the main odor component of rose oil. It has been traditionally used in aromatherapy for psychiatric disorders, but its scientific basis was unclear. This study suggests that inhalation of 2-PE may have anti-depressive effects mediated via the olfactory system, though it may also induce anxiety-like behavior in certain contexts. The study also notes that the effects of rose oil and 2-PE may vary depending on concentration, duration of exposure, and administration method. |
| 分子式 |
C8H10O
|
|---|---|
| 分子量 |
122.17
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| 精确质量 |
122.073
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| CAS号 |
60-12-8
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| 相关CAS号 |
2-Phenylethanol-d4;107473-33-6;2-Phenylethanol-d9;42950-74-3;2-Phenylethanol-d5;35845-63-7
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| PubChem CID |
6054
|
| 外观&性状 |
Colorless to light yellow liquid
|
| 密度 |
1.0±0.1 g/cm3
|
| 沸点 |
218.2±8.0 °C at 760 mmHg
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| 熔点 |
−27 °C(lit.)
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| 闪点 |
102.2±0.0 °C
|
| 蒸汽压 |
0.1±0.5 mmHg at 25°C
|
| 折射率 |
1.536
|
| LogP |
1.36
|
| tPSA |
20.23
|
| 氢键供体(HBD)数目 |
1
|
| 氢键受体(HBA)数目 |
1
|
| 可旋转键数目(RBC) |
2
|
| 重原子数目 |
9
|
| 分子复杂度/Complexity |
65
|
| 定义原子立体中心数目 |
0
|
| SMILES |
O([H])C([H])([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
|
| InChi Key |
WRMNZCZEMHIOCP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2
|
| 化学名 |
2-phenylethanol
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| 别名 |
Phenylethyl alcohol NSC 406252 NSC 406252 NSC406252 NSC-406252
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| HS Tariff Code |
2934.99.9001
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| 存储方式 |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| 溶解度 (体外实验) |
H2O : ~20 mg/mL (~163.72 mM)
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|---|---|
| 溶解度 (体内实验) |
配方 1 中的溶解度: 50 mg/mL (409.30 mM) in PBS (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液; 超声助溶。
请根据您的实验动物和给药方式选择适当的溶解配方/方案： 1、请先配制澄清的储备液(如：用DMSO配置50 或 100 mg/mL母液(储备液)); 2、取适量母液，按从左到右的顺序依次添加助溶剂，澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明，并不一定代表此产品 的实际溶解配方): 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline); 假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀/澄清；向上述体系中加入50 μL Tween-80，混合均匀/澄清；然后继续加入450 μL ddH2O (或 saline)定容至 1 mL； 3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例; 4、 如产品在配制过程中出现沉淀/析出，可通过加热(≤50℃)或超声的方式助溶; 5、为保证最佳实验结果，工作液请现配现用！ 6、如不确定怎么将母液配置成体内动物实验的工作液，请查看说明书或联系我们; 7、 以上所有助溶剂都可在 Invivochem.cn网站购买。 |
| 制备储备液 | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.1853 mL | 40.9266 mL | 81.8532 mL | |
| 5 mM | 1.6371 mL | 8.1853 mL | 16.3706 mL | |
| 10 mM | 0.8185 mL | 4.0927 mL | 8.1853 mL |
1、根据实验需要选择合适的溶剂配制储备液 (母液)：对于大多数产品，InvivoChem推荐用DMSO配置母液 (比如：5、10、20mM或者10、20、50 mg/mL浓度），个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;
2、如果您找不到您想要的溶解度信息，或者很难将产品溶解在溶液中，请联系我们;
3、建议使用下列计算器进行相关计算（摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等）;
4、母液配好之后，将其分装到常规用量，并储存在-20°C或-80°C，尽量减少反复冻融循环。
计算结果:
工作液浓度： mg/mL；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度，请首先与我们联系。
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
(1) 请确保溶液澄清之后，再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶；
(2) 一定要按顺序加入溶剂 (助溶剂) 。
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02624362 | ENROLLING BY INVITATION | Behavioral: Therapeutic Suggestion Behavioral: Asthmogenic Suggestion Other: Phenylethyl Alcohol odor |
Asthma | Universitaire Ziekenhuizen KU Leuven | 2015-08 | Not Applicable |
| NCT05908318 | NOT YET RECRUITING | Behavioral: olfactory training | Postoperative Delirium Preoperative Olfactory Training |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2023-07 | Not Applicable |
| NCT06290219 | NOT YET RECRUITING | Combination Product: platelet-rich plasma combined with hyaluronic acid Drug: Zinc Gluconate 10 MG Oral Tablet Device: 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil |
Effect of Drug Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis) | Taichung Veterans General Hospital | 2024-03-20 | Phase 3 |
| NCT01380691 | COMPLETEDWITH RESULTS | Drug: LY2216684 Drug: Placebo-matching LY2216684 Drug: Placebo-matching alcoholic beverage Drug: Alcoholic beverage |
Major Depressive Disorder | Eli Lilly and Company | 2011-06 | Phase 1 |
| NCT06066307 | RECRUITING | Other: Olfactory training | Loss of Smell Olfactory Disorder | Leigh Sowerby | 2023-09-25 | Phase 4 |
PHPS1 Sodium
BE 2254
环胞啶硫酸盐
Azido-PEG5-acid
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