| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5g |
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| 10g |
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| 25g |
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| 50g |
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| Other Sizes |
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| 靶点 |
Pharmatose DCL 14 does not have a specific biological target or receptor. As a pharmaceutical excipient, it is an inert ingredient used in drug formulations. Lactose is a sugar that can be metabolized by lactase in the body, but the DCL 14 grade is specifically designed for its physical properties as a tableting excipient rather than for any biological activity.
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|---|---|
| 体外研究 (In Vitro) |
在体外,Pharmatose DCL 14 用于药物制剂的开发。评估内容包括其流动性、可压缩性和与活性药物成分的相容性等物理性质。它不用于生物活性测定。其主要的体外应用是固体剂型的开发和测试。
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| 体内研究 (In Vivo) |
在体内,Pharmatose DCL 14 用作药物制剂中的赋形剂。它作为药物产品的一部分被摄入,通常被认为是安全的。乳糖在体内由乳糖酶代谢。然而,DCL 14 级乳糖本身并不用于治疗目的,而是作为活性药物成分的载体。
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| 酶活实验 |
对于非细胞检测,Pharmatose DCL 14 的表征采用 X 射线衍射、差示扫描量热法和粒度分析等技术。它不用于受体结合试验。其作用是作为药物制剂中的赋形剂,对其物理性质进行评估以确保药物产品质量的稳定性。
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| 细胞实验 |
对于体外细胞实验,Pharmatose DCL 14 通常不用于基于细胞的功能性分析。它可用于研究药物从固体剂型中的释放和溶出情况。然而,其主要用途是作为药物制剂开发中的辅料,而非作为细胞生物学研究的工具。
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| 动物实验 |
在体内动物研究中,Pharmatose DCL 14 通常不用于治疗或药理学研究。它可用作动物研究制剂中的赋形剂。其主要用途是制剂开发和作为乳糖的参考标准。目前尚无针对该赋形剂的全面体内药理学研究。
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| 药代性质 (ADME/PK) |
Pharmatose DCL 14 是一种结晶型α-乳糖一水合物。它有多种等级,包括 Pharmatose 200M 和 Pharmatose 450M,这些等级的粒径分布有所不同。该化合物应储存在阴凉干燥处。它仅供研究使用,除已批准的药品用途外,不得用于人类消费。
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| 毒性/毒理 (Toxicokinetics/TK) |
Pharmatose DCL 14 是一种常用的药用辅料,其毒性特征已得到充分证实。乳糖通常被认为是安全的。然而,乳糖不耐受者可能会出现胃肠道不适。该化合物仅供研究使用,除已批准的药品用途外,不得用于人类消费。
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| 其他信息 |
α-乳糖单水合物是一种糖苷。
Pharmatose DCL 14(也称为Pharmatose 200M或Pharmatose 450M,CAS 64044-51-5)是一种用于制药配方的乳糖级别。它是一种结晶的α-乳糖单水合物,经过处理以控制颗粒大小和流动特性。它通常用作片剂和胶囊中的填充剂、粘合剂或载体。仅供研究用途。 |
| 分子式 |
C12H24O12
|
|---|---|
| 分子量 |
360.31
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| 精确质量 |
360.127
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| CAS号 |
64044-51-5
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| PubChem CID |
104938
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| 外观&性状 |
White to off-white solid powder
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| 密度 |
1.525
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| 沸点 |
841.4ºC at 760 mmHg
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| 熔点 |
433 °F (NTP, 1992)
; 201-202 °C
; Decomposes at 203.5 °C
; White powder; MP: 222.8 °C; very soluble in water; slightly soluble in ethanol; insoluble in ethyl ether, chloroform /alpha-Lactose/
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| 闪点 |
462.7ºC
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| 折射率 |
1.652
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| tPSA |
198.76
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| 氢键供体(HBD)数目 |
9
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| 氢键受体(HBA)数目 |
12
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| 可旋转键数目(RBC) |
4
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| 重原子数目 |
24
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| 分子复杂度/Complexity |
382
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| 定义原子立体中心数目 |
10
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| SMILES |
C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O.O
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| InChi Key |
WSVLPVUVIUVCRA-KPKNDVKVSA-N
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| InChi Code |
InChI=1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
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| 化学名 |
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
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| HS Tariff Code |
2934.99.9001
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| 存储方式 |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| 溶解度 (体外实验) |
H2O: 100 mg/mL (277.54 mM)
DMSO: 50 mg/mL (138.77 mM) |
|---|---|
| 溶解度 (体内实验) |
配方 1 中的溶解度: ≥ 2.5 mg/mL (6.94 mM) (饱和度未知) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。
例如,若需制备1 mL的工作液,可将100 μL 25.0 mg/mL澄清DMSO储备液加入到400 μL PEG300中,混匀;然后向上述溶液中加入50 μL Tween-80,混匀;加入450 μL生理盐水定容至1 mL。 *生理盐水的制备:将 0.9 g 氯化钠溶解在 100 mL ddH₂O中,得到澄清溶液。 配方 2 中的溶解度: ≥ 2.5 mg/mL (6.94 mM) (饱和度未知) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。 例如,若需制备1 mL的工作液,可将 100 μL 25.0 mg/mL澄清DMSO储备液加入900 μL 20% SBE-β-CD生理盐水溶液中,混匀。 *20% SBE-β-CD 生理盐水溶液的制备(4°C,1 周):将 2 g SBE-β-CD 溶解于 10 mL 生理盐水中,得到澄清溶液。 View More
配方 3 中的溶解度: ≥ 2.5 mg/mL (6.94 mM) (饱和度未知) in 10% DMSO + 90% Corn Oil (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。 1、请先配制澄清的储备液(如:用DMSO配置50 或 100 mg/mL母液(储备液)); 2、取适量母液,按从左到右的顺序依次添加助溶剂,澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明,并不一定代表此产品 的实际溶解配方): 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline); 假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀/澄清;向上述体系中加入50 μL Tween-80,混合均匀/澄清;然后继续加入450 μL ddH2O (或 saline)定容至 1 mL; 3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例; 4、 如产品在配制过程中出现沉淀/析出,可通过加热(≤50℃)或超声的方式助溶; 5、为保证最佳实验结果,工作液请现配现用! 6、如不确定怎么将母液配置成体内动物实验的工作液,请查看说明书或联系我们; 7、 以上所有助溶剂都可在 Invivochem.cn网站购买。 |
| 制备储备液 | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7754 mL | 13.8769 mL | 27.7539 mL | |
| 5 mM | 0.5551 mL | 2.7754 mL | 5.5508 mL | |
| 10 mM | 0.2775 mL | 1.3877 mL | 2.7754 mL |
1、根据实验需要选择合适的溶剂配制储备液 (母液):对于大多数产品,InvivoChem推荐用DMSO配置母液 (比如:5、10、20mM或者10、20、50 mg/mL浓度),个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;
2、如果您找不到您想要的溶解度信息,或者很难将产品溶解在溶液中,请联系我们;
3、建议使用下列计算器进行相关计算(摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等);
4、母液配好之后,将其分装到常规用量,并储存在-20°C或-80°C,尽量减少反复冻融循环。
计算结果:
工作液浓度: mg/mL;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度,请首先与我们联系。
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。
(1) 请确保溶液澄清之后,再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶;
(2) 一定要按顺序加入溶剂 (助溶剂) 。
Link: https://clinicaltrials.gov/ct2/show/NCT06724705
Conditions:Lactose Intolerance, Adult TypeLink: https://clinicaltrials.gov/ct2/show/NCT02584439
Conditions:Healthy|Vascular Stiffness|AgingLink: https://clinicaltrials.gov/ct2/show/NCT03582176
Conditions:Elbow Fracture|Elbow Injury|Elbow Dislocation
Title:Human Cerebral Blood Flow Regulation
Status:Completed
updateDate:2025-10-03
Ctid:NCT04265053
Link: https://clinicaltrials.gov/ct2/show/NCT04265053
Conditions:Cerebral Arterial DiseasesLink: https://clinicaltrials.gov/ct2/show/NCT06746285
Conditions:Gastrointestinal Tolerance of Probiotics in InfantsLink: https://clinicaltrials.gov/ct2/show/NCT01404754
Conditions:Psychological Effects of Study DrugLink: https://clinicaltrials.gov/ct2/show/NCT04924530
Conditions:Cardiovascular Risk Factor|Lipaemia|Metabolic DiseaseLink: https://clinicaltrials.gov/ct2/show/NCT02999022
Conditions:FracturesLink: https://clinicaltrials.gov/ct2/show/NCT00888680
Conditions:MigraineLink: https://clinicaltrials.gov/ct2/show/NCT01041755
Conditions:Hepatic EncephalopathyLink: https://clinicaltrials.gov/ct2/show/NCT03497598
Conditions:Urinary Tract InfectionsLink: https://clinicaltrials.gov/ct2/show/NCT01434745
Conditions:Smith-Lemli-Opitz SyndromeLink: https://clinicaltrials.gov/ct2/show/NCT00876161
Conditions:HealthyLink: https://clinicaltrials.gov/ct2/show/NCT03878511
Conditions:Bacterial VaginosesLink: https://clinicaltrials.gov/ct2/show/NCT01550107
Conditions:SarcopeniaLink: https://clinicaltrials.gov/ct2/show/NCT02042521
Conditions:Nicotine Dependence, Cigarettes, With WithdrawalLink: https://clinicaltrials.gov/ct2/show/NCT01644877
Conditions:ParainfluenzaLink: https://clinicaltrials.gov/ct2/show/NCT01723592
Conditions:Breast CancerLink: https://clinicaltrials.gov/ct2/show/NCT03121222
Conditions:Glutathione Metabolism AnemiasLink: https://clinicaltrials.gov/ct2/show/NCT02636413
Conditions:Lactose IntoleranceLink: https://clinicaltrials.gov/ct2/show/NCT01675986
Conditions:Feeling AnxiousLink: https://clinicaltrials.gov/ct2/show/NCT02787707
Conditions:Nausea|VomitingLink: https://clinicaltrials.gov/ct2/show/NCT02566798
Conditions:OsteoarthritisLink: https://clinicaltrials.gov/ct2/show/NCT02596360
Conditions:Experimental Pain|HyperalgesiaLink: https://clinicaltrials.gov/ct2/show/NCT02448940
Conditions:Overweight and ObesityLink: https://clinicaltrials.gov/ct2/show/NCT01848119
Conditions:PainLink: https://clinicaltrials.gov/ct2/show/NCT02214095
Conditions:Chronic PeriodontitisLink: https://clinicaltrials.gov/ct2/show/NCT02172508
Conditions:Pulmonary Disease, Chronic ObstructiveLink: https://clinicaltrials.gov/ct2/show/NCT00980031
Conditions:Myocardial RemodelingLink: https://clinicaltrials.gov/ct2/show/NCT01151306
Conditions:Chronic Obstructive Pulmonary DiseaseLink: https://clinicaltrials.gov/ct2/show/NCT01277237
Conditions:Non Alcoholic Fatty Liver DiseaseLink: https://clinicaltrials.gov/ct2/show/NCT00979056
Conditions:DiarrhoeaLink: https://clinicaltrials.gov/ct2/show/NCT00624754
Conditions:Obstructive Airway DiseaseLink: https://clinicaltrials.gov/ct2/show/NCT01748279
Conditions:COPDLink: https://clinicaltrials.gov/ct2/show/NCT01812967
Conditions:Glycemic Control|Gastrointestinal Hormone Response|Healthy Young MenLink: https://clinicaltrials.gov/ct2/show/NCT01575678
Conditions:Nocturnal EnuresisLink: https://clinicaltrials.gov/ct2/show/NCT01028014
Conditions:Urethral Sphincter ActivityLink: https://clinicaltrials.gov/ct2/show/NCT00682214
Conditions:Vitamin D DeficiencyLink: https://clinicaltrials.gov/ct2/show/NCT01094925
Conditions:PainLink: https://clinicaltrials.gov/ct2/show/NCT01136317
Conditions:Gastroesophageal RefluxLink: https://clinicaltrials.gov/ct2/show/NCT01185418
Conditions:Normal VolunteersLink: https://clinicaltrials.gov/ct2/show/NCT00983177
Conditions:Calcific TendonitisLink: https://clinicaltrials.gov/ct2/show/NCT00599859
Conditions:Lactose IntoleranceLink: https://clinicaltrials.gov/ct2/show/NCT00841230
Conditions:TinnitusLink: https://clinicaltrials.gov/ct2/show/NCT00351117
Conditions:Raynaud's DiseaseLink: https://clinicaltrials.gov/ct2/show/NCT00504946
Conditions:AsthmaLink: https://clinicaltrials.gov/ct2/show/NCT00311259
Conditions:Oxidative Stress|Inflammatory Stress|Myocardial Ischaemia