| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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| 毒性/毒理 (Toxicokinetics/TK) |
妊娠期和哺乳期影响
◉ 哺乳期用药概述 匹可硫酸钠不被胃肠道吸收,其被吸收的活性代谢物在母乳中检测不到。哺乳期妇女可以服用匹可硫酸钠,无需特殊注意事项。 ◉ 对母乳喂养婴儿的影响 截至修订日期,未找到相关的已发表信息。 ◉ 对泌乳和母乳的影响 截至修订日期,未找到相关的已发表信息。 |
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| 参考文献 |
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| 其他信息 |
匹可硫酸钠是一种芳基硫酸盐,属于吡啶类化合物。
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| 分子式 |
C18H13NNA2O8S2
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|---|---|
| 分子量 |
481.4
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| 精确质量 |
480.9878
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| CAS号 |
10040-45-6
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| PubChem CID |
68654
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| 外观&性状 |
Typically exists as solid at room temperature
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| 熔点 |
272 - 275ºC
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| LogP |
4.101
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| tPSA |
162.51
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| 氢键供体(HBD)数目 |
0
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| 氢键受体(HBA)数目 |
9
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| 可旋转键数目(RBC) |
5
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| 重原子数目 |
31
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| 分子复杂度/Complexity |
633
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| 定义原子立体中心数目 |
0
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| SMILES |
S(=O)(=O)([O-])OC1C([H])=C([H])C(=C([H])C=1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=N1)C1C([H])=C([H])C(=C([H])C=1[H])OS(=O)(=O)[O-].[Na+].[Na+]
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| InChi Key |
GOZDTZWAMGHLDY-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25/h1-12,18H,(H,20,21,22)(H,23,24,25)/q2*+1/p-2
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| 化学名 |
4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt
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| 别名 |
Sodium picosulphateSodium Picosulfate LA 391 Laxidogol Natrii picosulfas Picosulfate sodium Guttalax
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| HS Tariff Code |
2934.99.9001
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| 存储方式 |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 注意: 请将本产品存放在密封且受保护的环境中,避免吸湿/受潮。 |
| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| 溶解度 (体外实验) |
DMSO : ~100 mg/mL (~207.72 mM)
H2O : ≥ 100 mg/mL (~207.72 mM) |
|---|---|
| 溶解度 (体内实验) |
配方 1 中的溶解度: ≥ 2.5 mg/mL (5.19 mM) (饱和度未知) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。
例如,若需制备1 mL的工作液,可将100 μL 25.0 mg/mL澄清DMSO储备液加入到400 μL PEG300中,混匀;然后向上述溶液中加入50 μL Tween-80,混匀;加入450 μL生理盐水定容至1 mL。 *生理盐水的制备:将 0.9 g 氯化钠溶解在 100 mL ddH₂O中,得到澄清溶液。 配方 2 中的溶解度: ≥ 2.5 mg/mL (5.19 mM) (饱和度未知) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。 例如,若需制备1 mL的工作液,可将 100 μL 25.0 mg/mL澄清DMSO储备液加入900 μL 20% SBE-β-CD生理盐水溶液中,混匀。 *20% SBE-β-CD 生理盐水溶液的制备(4°C,1 周):将 2 g SBE-β-CD 溶解于 10 mL 生理盐水中,得到澄清溶液。 View More
配方 3 中的溶解度: ≥ 2.5 mg/mL (5.19 mM) (饱和度未知) in 10% DMSO + 90% Corn Oil (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。 配方 4 中的溶解度: 100 mg/mL (207.72 mM) in PBS (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液; 超声助溶. 1、请先配制澄清的储备液(如:用DMSO配置50 或 100 mg/mL母液(储备液)); 2、取适量母液,按从左到右的顺序依次添加助溶剂,澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明,并不一定代表此产品 的实际溶解配方): 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline); 假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀/澄清;向上述体系中加入50 μL Tween-80,混合均匀/澄清;然后继续加入450 μL ddH2O (或 saline)定容至 1 mL; 3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例; 4、 如产品在配制过程中出现沉淀/析出,可通过加热(≤50℃)或超声的方式助溶; 5、为保证最佳实验结果,工作液请现配现用! 6、如不确定怎么将母液配置成体内动物实验的工作液,请查看说明书或联系我们; 7、 以上所有助溶剂都可在 Invivochem.cn网站购买。 |
| 制备储备液 | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0773 mL | 10.3864 mL | 20.7727 mL | |
| 5 mM | 0.4155 mL | 2.0773 mL | 4.1545 mL | |
| 10 mM | 0.2077 mL | 1.0386 mL | 2.0773 mL |
1、根据实验需要选择合适的溶剂配制储备液 (母液):对于大多数产品,InvivoChem推荐用DMSO配置母液 (比如:5、10、20mM或者10、20、50 mg/mL浓度),个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;
2、如果您找不到您想要的溶解度信息,或者很难将产品溶解在溶液中,请联系我们;
3、建议使用下列计算器进行相关计算(摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等);
4、母液配好之后,将其分装到常规用量,并储存在-20°C或-80°C,尽量减少反复冻融循环。
计算结果:
工作液浓度: mg/mL;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度,请首先与我们联系。
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。
(1) 请确保溶液澄清之后,再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶;
(2) 一定要按顺序加入溶剂 (助溶剂) 。
Link: https://clinicaltrials.gov/ct2/show/NCT04598880
Conditions:Colonic DiseasesLink: https://clinicaltrials.gov/ct2/show/NCT07218523
Conditions:Bowel Cleansing Prior to Clinical ProceduresLink: https://clinicaltrials.gov/ct2/show/NCT05436054
Conditions:Colon Disease
Title:TES RCT Fleet Enema vs Oral Mechanical Bowel Prep
Status:Recruiting
updateDate:2024-08-27
Ctid:NCT05148494
Link: https://clinicaltrials.gov/ct2/show/NCT05148494
Conditions:Colorectal Neoplasms|SurgeryLink: https://clinicaltrials.gov/ct2/show/NCT05726097
Conditions:Colon Cancer|Inflammatory Bowel Diseases|Gastrointestinal Bleed|Colon PolypLink: https://clinicaltrials.gov/ct2/show/NCT05144295
Conditions:Clinical Efficacy|Treatment Efficacy|Drug Side EffectLink: https://clinicaltrials.gov/ct2/show/NCT04593446
Conditions:Colorectal CancerLink: https://clinicaltrials.gov/ct2/show/NCT04153084
Conditions:Digestive IllnessLink: https://clinicaltrials.gov/ct2/show/NCT02765971
Conditions:Intestinal Recovery After Cesarean SectionLink: https://clinicaltrials.gov/ct2/show/NCT03074448
Conditions:Bowel PreparationLink: https://clinicaltrials.gov/ct2/show/NCT02239692
Conditions:Bowel CleansingLink: https://clinicaltrials.gov/ct2/show/NCT01554111
Conditions:Cathartic ColonLink: https://clinicaltrials.gov/ct2/show/NCT00885430
Conditions:Hemodynamics|HyponatremiaLink: https://clinicaltrials.gov/ct2/show/NCT00885274
Conditions:ColonoscopyLink: https://clinicaltrials.gov/ct2/show/NCT01689792
Conditions:Colorectal CancerLink: https://clinicaltrials.gov/ct2/show/NCT02211911
Conditions:HealthyLink: https://clinicaltrials.gov/ct2/show/NCT00576810
Conditions:ConstipationLink: https://clinicaltrials.gov/ct2/show/NCT01073930
Conditions:Bowel PreparationLink: https://clinicaltrials.gov/ct2/show/NCT01627171
Conditions:Endoscopy|Bowel Preparation SolutionsLink: https://clinicaltrials.gov/ct2/show/NCT01356407
Conditions:ColonoscopyLink: https://clinicaltrials.gov/ct2/show/NCT01073943
Conditions:Bowel PreparationLink: https://clinicaltrials.gov/ct2/show/NCT01292109
Conditions:Bowel CleanlinessLink: https://clinicaltrials.gov/ct2/show/NCT01093274
Conditions:Bowel PreparationLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2018-003257-16
Condition:Colonoscopy bowel preparationKolonoszkópia előkészítésLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2017-002811-33
Condition:Surgery proctologicalcirugía proctológicaLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-001062-10
Condition:Bowel cleansingLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-002186-30
Condition:Bowel cleansing prior to any procedure that requires a clean bowel, e.g. colonoscopy, surgical, video capsule or radiological procedures.Link: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-001620-20
Condition:Cleansing of colonReinigung des DarmesLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2012-005754-38
Condition:We do not use these products in a concrete disease. We compare the effectiveness of these products to obtain an accurate bowel cleansing before performing a capsule endoscopic study.No usamos estos productos en una patología en concreto, sino que nuestro objetivo es comparar la eficacia de ambos para obtener una adecuada limpieza intestinal en aquellos pacientes que van a ser sometidos a un estudio con cápsula endoscópicaLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2012-004367-44
Condition:SENSORY AND MOTOR RESPONSE OF DESCENDING COLON TO DISTENSION WILL BE STUDIED IN HEALTHY SUBJECTSLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2012-004327-21
Condition:bowel preparation before colonoscopydarmreiniging voor coloscopieLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2011-004384-75
Condition:Patients who need a colonoscopy for screening, surveillance or diagnosis of a disease have to be prepared by bowel cleansingPatienten die een coloscopie moeten ondergaan vanwege screening, opvolging of diagnose van een ziekte moeten darmvoorbereiding krijgenLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2011-002364-25
Condition:Patients with clinical symptoms or polyp history scheduled for either a diagnostic/surveillance colonoscopy or for a screening procedure in patients with a personal or familial risk of colon neoplasia.Link: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2011-000587-10
Condition:� Subjects who are candidate to undergo colonoscopy:� Diagnosis� Screening� Follow-up after previous polipectomyLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2009-016874-34
Condition:We are investigating the effect of mechanical bowel preparation, such as Picolax, on aerobic exercise capacity in healthy volunteers.Link: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2007-003735-23
Condition:Bowel preparation prior to elective complete colonoscopy.As 'bowel preparation' is not a specific medical condition, there is no MedDRA term.Link: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2007-001834-15
Condition:Pacientes de ambos sexos a los que se les vaya a realizar una exploración endoscópica colónica que precisara evacuación intestinal previaLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2007-002087-10
Condition:To compare the efficacy and safety of 4 weeks treatment with sodium picosulphate Dulcolax®, Laxoberal® drops to placebo in patients with functional constipationLink: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2004-001487-43
Condition:Gut cleansing prior to colonoscopy procedure