| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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| 体外研究 (In Vitro) |
体外活性：阿坎酸的生物利用度较低，但也具有出色的耐受性和安全性。与 FDA 批准的其他酒精依赖治疗药物纳曲酮和双硫仑相比，阿坎酸的独特之处在于它不被肝脏代谢，也不受饮酒的影响，因此可以用于肝炎或肝病患者疾病（酒精依赖者中常见的合并症）和继续饮酒的患者。
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| 体内研究 (In Vivo) |
阿坎酸钙（Campral EC）是一种 GABA 受体激动剂和谷氨酸能系统调节剂；减少酒精成瘾动物模型的饮酒量。
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| 动物实验 |
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| 毒性/毒理 (Toxicokinetics/TK) |
Effects During Pregnancy and Lactation
◉ Summary of Use during Lactation No information is available on the clinical use of acamprosate during breastfeeding. Based on its chemical properties it is likely to enter milk. However, the oral bioavailability of acamprosate is only 11%, so systemic effects in the breastfed infant are unlikely. If acamprosate is required by the mother, it is not a reason to discontinue breastfeeding. Monitor the breastfed infant for diarrhea. ◉ Effects in Breastfed Infants Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk Relevant published information was not found as of the revision date. |
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| 参考文献 |
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| 其他信息 |
Acamprosate calcium is an organic calcium salt. It contains an acamprosate(1-).
Structural analog of taurine that is used for the prevention of relapse in individuals with ALCOHOLISM. See also: Acamprosate (has active moiety). |
| 分子式 |
C10H20CAN2O8S2
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|---|---|---|
| 分子量 |
400.47
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| 精确质量 |
400.028
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| CAS号 |
77337-73-6
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| 相关CAS号 |
Acamprosate-d3 calcium;1225580-94-8;Acamprosate;77337-76-9
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| PubChem CID |
155434
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| 外观&性状 |
White to off-white solid powder
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| 熔点 |
>300ºC
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| LogP |
1.059
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| tPSA |
189.36
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| 氢键供体(HBD)数目 |
2
|
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| 氢键受体(HBA)数目 |
8
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| 可旋转键数目(RBC) |
6
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| 重原子数目 |
23
|
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| 分子复杂度/Complexity |
202
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| 定义原子立体中心数目 |
0
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|
| InChi Key |
BUVGWDNTAWHSKI-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2
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| 化学名 |
Calcium 3-(acetylamino)propane-1-sulfonate
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| 别名 |
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| HS Tariff Code |
2934.99.9001
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| 存储方式 |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 注意： 请将本产品存放在密封且受保护的环境中，避免吸湿/受潮。 |
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| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| 溶解度 (体外实验) |
|
|---|
| 制备储备液 | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4971 mL | 12.4853 mL | 24.9707 mL | |
| 5 mM | 0.4994 mL | 2.4971 mL | 4.9941 mL | |
| 10 mM | 0.2497 mL | 1.2485 mL | 2.4971 mL |
1、根据实验需要选择合适的溶剂配制储备液 (母液)：对于大多数产品，InvivoChem推荐用DMSO配置母液 (比如：5、10、20mM或者10、20、50 mg/mL浓度），个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;
2、如果您找不到您想要的溶解度信息，或者很难将产品溶解在溶液中，请联系我们;
3、建议使用下列计算器进行相关计算（摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等）;
4、母液配好之后，将其分装到常规用量，并储存在-20°C或-80°C，尽量减少反复冻融循环。
计算结果:
工作液浓度： mg/mL；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度，请首先与我们联系。
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
(1) 请确保溶液澄清之后，再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶；
(2) 一定要按顺序加入溶剂 (助溶剂) 。
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT06269627 | NOT YET RECRUITING | Drug: Acamprosate calcium Other: Placebo |
Alcohol Use Disorder | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 2024-07-04 | Phase 4 |
| NCT03634917 | COMPLETED | Drug: Acamprosate Calcium Drug: Calcium Carbonate Drug: Placebo Drug: Placebo lead in |
Alcoholism | Technische Universität Dresden | 2020-08-05 | Phase 3 |
| NCT02217007 | WITHDRAWN | Drug: SNC-102 sustained release tablet | Tourette Syndrome | Synchroneuron Inc. | 2015-04 | Phase 2 |
| NCT00591565 | COMPLETEDWITH RESULTS | Drug: Acamprosate | Anxiety | State University of New York - Upstate Medical University | 2006-06 | Not Applicable |
| NCT02064010 | WITHDRAWN | Drug: SNC-102 Drug: Placebo |
Drug-induced Tardive Dyskinesia | Synchroneuron Inc. | 2014-02 | Phase 2 |
Ethanol exposure in a vapor chamber and ethanol withdrawal experiment.Neuropharmacology. 2012 Jun;62(8):2480-8. |
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Simplified illustration of the cortical-striatal circuit in ENT1 null mice.Neuropharmacology. 2012 Jun;62(8):2480-8. |
N-甲基-beta-咔啉-3-羧酰胺
加巴喷丁盐酸盐
光甘草定
左环丝氨酸
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