Description: Givinostat (formerly ITF2357; Gavinostat) is a potent and orally bioavailable inhibitor of both class I and class II histone deacetylase (HDAC) with potential anticancer activity. It inhibits HDAC with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat is also a potent inhibitor of hematopoietic colony formation by JAKEV617F-bearing progenitor cells from chronic myeloproliferative neoplasms in vitro.
References: Mol Med. 2005 Jan-Dec;11(1-12):1-15; Leukemia. 2007 Sep;21(9):1892-900; Mol Med. 2011 May-Jun;17(5-6):369-77.
Related CAS: 732302-99-7 (HCl hydrate); 497833-27-9 (free base); 199657-29-9 (HCl)