Description: Birinapant (TL32711; TL-32711; TL 32711) is a novel and potent bivalent peptidomimetic
of SMAC (second mitochondrial-derived activator of caspases) and
inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins. It has potential anticancer activity. Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with a Kd of<1 nM in a cell-free assay, and is less potent to XIAP.
References: Breast Cancer Res Treat. 2013 Jan;137(2):359-71.