| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 500mg |
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| 10g |
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| 50g |
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| Other Sizes |
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| 体外研究 (In Vitro) |
随着生长培养基中CV浓度的增加，菌株RB1对链霉素的敏感性也增加。细胞色素 aa3 水平和链霉素敏感性均随着生长培养基中 CV 浓度的增加而升高。枯草芽孢杆菌在没有细胞色素 aa3 的情况下无法积累链霉素 [1]。链霉素对 tRNA 选择有影响。导致链霉素耐药性的突变通常局限于蛋白质 S12，并且这些变异中的大多数在 tRNA 选择过程中表现出更大的区分度 [2]。
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| 毒性/毒理 (Toxicokinetics/TK) |
Effects During Pregnancy and Lactation
◉ Summary of Use during Lactation Similar to other aminoglycoside antibiotics, streptomycin is poorly excreted into breastmilk. Newborn infants apparently absorb small amounts of aminoglycosides, but serum levels are far below those attained when treating newborn infections and systemic effects of streptomycin are unlikely. Older infants would be expected to absorb even less streptomycin Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis. ◉ Effects in Breastfed Infants Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk One observational study found no inhibition of lactation by streptomycin. |
| 参考文献 | |
| 其他信息 |
Streptomycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
Streptomycin sulfate (2:3) (salt) appears as an antibacterial. White to light gray or pale buff powder with faint amine-like odor. Streptomycin sulfate is an aminoglycoside sulfate salt. It is functionally related to a streptomycin. Streptomycin Sulfate is the sulfate salt form of streptomycin, an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial property. Streptomycin sulfate binds to the S12 protein of the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis. See also: Streptomycin (has active moiety) ... View More ... |
| 精确质量 |
1456.433
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|---|---|
| CAS号 |
3810-74-0
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| 相关CAS号 |
Streptomycin;57-92-1
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| PubChem CID |
19648
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| 外观&性状 |
White to off-white solid powder
|
| 沸点 |
948.2ºC at 760 mmHg
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| 闪点 |
527.3ºC
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| 折射率 |
-85 ° (C=1, H2O)
|
| tPSA |
911.8
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| 氢键供体(HBD)数目 |
30
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| 氢键受体(HBA)数目 |
42
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| 可旋转键数目(RBC) |
18
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| 重原子数目 |
95
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| 分子复杂度/Complexity |
1020
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| 定义原子立体中心数目 |
30
|
| SMILES |
S(=O)(=O)(O[H])O[H].S(=O)(=O)(O[H])O[H].S(=O)(=O)(O[H])O[H].O([C@@]1([H])[C@@]([H])([C@@](C([H])=O)([C@]([H])(C([H])([H])[H])O1)O[H])O[C@@]1([H])[C@]([H])([C@@]([H])([C@]([H])([C@]([H])(C([H])([H])O[H])O1)O[H])O[H])N([H])C([H])([H])[H])[C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@]([H])([C@]1([H])/N=C(\N([H])[H])/N([H])[H])O[H])/N=C(\N([H])[H])/N([H])[H])O[H])O[H].O([C@@]1([H])[C@@]([H])([C@@](C([H])=O)([C@]([H])(C([H])([H])[H])O1)O[H])O[C@@]1([H])[C@]([H])([C@@]([H])([C@]([H])([C@]([H])(C([H])([H])O[H])O1)O[H])O[H])N([H])C([H])([H])[H])[C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@]([H])([C@]1([H])/N=C(\N([H])[H])/N([H])[H])O[H])/N=C(\N([H])[H])/N([H])[H])O[H])O[H]
|
| InChi Key |
QTENRWWVYAAPBI-YCRXJPFRSA-N
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| InChi Code |
InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;;;/m00.../s1
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| 化学名 |
2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acid
|
| HS Tariff Code |
2934.99.9001
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| 存储方式 |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 注意： 请将本产品存放在密封且受保护的环境中（例如氮气保护），避免吸湿/受潮和光照。 |
| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| 溶解度 (体外实验) |
H2O : ≥ 100 mg/mL (~137.23 mM)
DMSO :< 1 mg/mL |
|---|---|
| 溶解度 (体内实验) |
配方 1 中的溶解度: 100 mg/mL (137.23 mM) in PBS (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液; 超声助溶。
请根据您的实验动物和给药方式选择适当的溶解配方/方案： 1、请先配制澄清的储备液(如：用DMSO配置50 或 100 mg/mL母液(储备液)); 2、取适量母液，按从左到右的顺序依次添加助溶剂，澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明，并不一定代表此产品 的实际溶解配方): 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline); 假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀/澄清；向上述体系中加入50 μL Tween-80，混合均匀/澄清；然后继续加入450 μL ddH2O (或 saline)定容至 1 mL； 3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例; 4、 如产品在配制过程中出现沉淀/析出，可通过加热(≤50℃)或超声的方式助溶; 5、为保证最佳实验结果，工作液请现配现用！ 6、如不确定怎么将母液配置成体内动物实验的工作液，请查看说明书或联系我们; 7、 以上所有助溶剂都可在 Invivochem.cn网站购买。 |
计算结果:
工作液浓度： mg/mL；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度，请首先与我们联系。
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
(1) 请确保溶液澄清之后，再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶；
(2) 一定要按顺序加入溶剂 (助溶剂) 。
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT00004444 | COMPLETED | Drug: paromomycin Drug: streptomycin |
Tuberculosis, Pulmonary | FDA Office of Orphan Products Development | 1994-11 | Not Applicable |
| NCT00128466 | COMPLETED | Drug: gentamicin Drug: streptomycin |
Plague | Centers for Disease Control and Prevention | 2004-08 | Phase 2 Phase 3 |
| NCT01432925 | COMPLETED | Procedure: surgical intervention on Buruli ulcer | Buruli Ulcer Mycobacterium Ulcerans Disease |
University Medical Center Groningen | 2011-09 | Not Applicable |
| NCT04110340 | RECRUITING | Drug: Ciprofloxacin Drug: Streptomycin Drug: Gentamicin |
Plague, Bubonic Plague, Pneumonic |
University of Oxford | 2020-02-15 | Phase 3 |
| NCT02604849 | COMPLETED | Drug: Neomycin Drug: Streptomycin Drug: Gentamicins |
Patients Colonized by Klebsiella Pneumoniae |
Maimónides Biomedical Research Institute of Córdoba | 2012-07 |
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