Salbutamol (AH-3365; Albuterol) DEA controlled substance

别名: Salbutamol Albuterol Proventil Sultanol Aerolin Albuterol Sulfate Proventil Salbutamol Sultanol Ventolin 沙丁胺醇; 舒喘灵; 舒喘宁;嗽必妥; 柳丁氨醇; 1-(4-羟基-3-羟甲基苯基)-2-(叔丁氨基)乙醇; R-舒喘宁;甲醇中沙丁胺醇溶液标准物质;沙丁胺醇 EP标准品;沙丁胺醇 USP标准品;沙丁胺醇 标准品;沙丁胺醇(沙丁胺醇); 1-(4-羟基-3-羟甲基苯基-2-(叔丁氨基)乙醇; 沙丁胺醇D9;舒喘灵 溶液; 舒喘灵,柳丁氨醇,舒喘宁;沙丁胺醇 1G
目录号: V14281 纯度: ≥98%
Salbutamol (AH3365) 是一种有效的、选择性的、短效的 β2-肾上腺素受体激动剂,IC50 为 8.93 µM。
Salbutamol (AH-3365; Albuterol) CAS号: 18559-94-9
产品类别: Adrenergic Receptor
产品仅用于科学研究,不针对患者销售
规格 价格 库存 数量
1g
2g
5g
10g
Other Sizes

Other Forms of Salbutamol (AH-3365; Albuterol):

  • 硫酸沙丁胺醇气雾剂
  • Salbutamol-d3 (Albutamol-d3; Albuterol-d3; AH-3365-d3)
  • Salbutamol-d9 (Albuterol-d9; Albuterol-d9; AH-3365-d9)
  • Salbutamol-d9 acetate (Albuterol-d9 acetate; AH-3365-d9 acetate)
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InvivoChem产品被CNS等顶刊论文引用
产品描述
Salbutamol (AH3365) 是一种有效的、选择性的、短效的 β2-肾上腺素能受体激动剂,IC50 为 8.93 µM。沙丁胺醇用于治疗哮喘和慢性阻塞性肺病。它对 β2 受体的选择性比 β1 受体高 29 倍,因此它对肺部 β 受体的特异性高于心脏中 β1 肾上腺素能受体。
生物活性&实验参考方法
药代性质 (ADME/PK)
吸收、分布和排泄
吸入后,沙丁胺醇局部作用于支气管平滑肌,药物最初在血液中检测不到。2至3小时后,血药浓度会降低,这可能是由于部分药物被吞咽并在肠道中吸收所致。特别是,吸入推荐剂量后,沙丁胺醇的全身浓度很低。一项针对12名健康男性和女性受试者的试验,使用较高剂量(1080微克沙丁胺醇碱)进行,结果表明,当使用推进剂HFA-134a给药时,给药后血浆平均峰浓度约为3纳克/毫升。与氯氟烃推进的沙丁胺醇吸入器(Tmax = 0.17 小时)相比,使用 VENTOLIN(沙丁胺醇)HFA 后,达峰时间(Tmax)有所延迟(Tmax = 0.42 小时)。
口服给药后,58-78% 的剂量在 24 小时内经尿液排出,其中约 60% 以代谢物的形式排出。少量药物经粪便排出。
静脉注射沙丁胺醇的分布容积记录为 156 ± 38 升。
口服沙丁胺醇的肾清除率为 272 ± 38 毫升/分钟,静脉注射后为 291 ± 70 毫升/分钟。此外,口服给药后,主要硫酸盐结合代谢物的肾清除率为 98.5 ± 23.5 ml/min。
消除途径:肾脏,69% 至 90%(其中 60% 以代谢物形式排出)。粪便,4%。
缓释片:单次给药后,其生物利用度约为普通片剂的 80%,无论是否与食物同服;但在稳态时,其生物利用度为速释片剂的 100%。食物会降低吸收速率,但不影响生物利用度。
口服后吸收迅速且良好。
达峰时间:糖浆:2 小时内。片剂:2 至 3 小时起效。
尚不清楚沙丁胺醇是否会分泌到人乳中。
代谢/代谢物
沙丁胺醇不在肺部代谢,而是在肝脏转化为 4'-O-硫酸酯(沙丁胺醇 4'-O-硫酸酯),其药理活性可忽略不计。它也可能通过氧化脱氨和/或与葡萄糖醛酸结合代谢。沙丁胺醇最终以游离药物和代谢物的形式经尿液排出。
通过苯酚磺基转移酶 (PST) 进行硫酸盐结合代谢为无活性的 4'-O-硫酸酯。与沙丁胺醇的 (S)-对映体相比,沙丁胺醇的 (R)-对映体更容易被 PST 代谢(代谢速率高出十倍)。
在组织和血液中被酯酶水解为活性化合物可待因醇。该药物还可通过结合代谢生成沙丁胺醇 4'-O-硫酸盐。
消除途径:吸入剂量约 72% 在 24 小时内经尿液排出,其中 28% 为原药,44% 为代谢物。
半衰期:1.6 小时
生物半衰期
吸入或口服沙丁胺醇的消除半衰期记录为 2.7 至 5 小时,而沙丁胺醇的表观终末血浆半衰期记录约为 4.6 小时。
消除:3.8 至 6 小时。
毒性/毒理 (Toxicokinetics/TK)
毒性概述
沙丁胺醇是一种β2-肾上腺素能激动剂,因此它能刺激β2-肾上腺素能受体。沙丁胺醇与肺部β2-受体结合,导致支气管平滑肌松弛。据信,沙丁胺醇通过激活腺苷酸环化酶增加cAMP的产生,其作用由cAMP介导。细胞内cAMP水平升高会增加cAMP依赖性蛋白激酶A的活性,从而抑制肌球蛋白的磷酸化并降低细胞内钙离子浓度。细胞内钙离子浓度降低会导致平滑肌松弛和支气管扩张。除了支气管扩张作用外,沙丁胺醇还能抑制肥大细胞释放支气管收缩剂,抑制微血管渗漏,并增强黏液纤毛清除功能。
毒性数据
LD50=1100 mg/kg(小鼠口服)
相互作用
在接受地高辛治疗10天的健康受试者中,单次静脉或口服沙丁胺醇后,观察到血清地高辛浓度下降16-22%。
肾上腺素、其他口服吸入的拟交感神经胺类药物:可能增强拟交感神经作用并增加毒性风险。避免与沙丁胺醇合用。
单胺氧化酶抑制剂、三环类抗抑郁药:可能引起严重的心血管不良反应和毒性风险。避免与沙丁胺醇合用。
普萘洛尔和其他β受体阻滞剂:可能拮抗沙丁胺醇的作用。谨慎合用。
非人类毒性值
小鼠口服LD50 > 2 g/kg
参考文献
Clin Sci (Lond).1986 Feb;70(2):159-65.
其他信息
治疗用途
支气管扩张剂;宫缩抑制剂
沙丁胺醇……适用于支气管哮喘的症状治疗,以及可能伴随支气管炎、肺气肿和其他阻塞性气道疾病发生的可逆性支气管痉挛的治疗。(美国产品标签包含)
沙丁胺醇适用于儿童患者急性高钾血症的临时治疗。 /未包含在美国产品标签中/
/ExpTher/ 口服吸入沙丁胺醇已在研究中用于预防或缓解部分高钾性家族性周期性麻痹患者的肌肉麻痹发作。
药物警告
震颤似乎是沙丁胺醇最常见的报告不良反应,在各种剂量药物的临床试验中,高达 20% 的患者会出现震颤。沙丁胺醇的其他常见不良反应包括紧张、恶心、心动过速、心悸、胸痛和头晕。……
据报道,沙丁胺醇还会导致母体和胎儿心动过速和高血糖(尤其是在糖尿病患者中),以及母体低血压、急性充血性心力衰竭、肺水肿和死亡。
沙丁胺醇可能会延迟早产。由于可能干扰子宫收缩,建议孕妇谨慎使用本品治疗支气管痉挛。
妊娠风险等级:C / 风险无法排除。目前缺乏充分、对照良好的临床研究,动物研究也未显示对胎儿的风险或缺乏相关数据。妊娠期间使用本品可能对胎儿造成伤害;但潜在获益可能大于潜在风险。/
有关沙丁胺醇(共22条)的更多药物警告(完整)数据,请访问HSDB记录页面。
药效学
沙丁胺醇(INN)或阿布特罗(USAN)是一种中度选择性β2受体激动剂,其结构与特布他林相似,广泛用作支气管扩张剂,用于治疗哮喘和其他慢性阻塞性气道疾病。 R-异构体左旋沙丁胺醇具有支气管扩张作用,而S-异构体则会增加支气管反应性。R-对映体以纯左旋沙丁胺醇的形式销售,因此,由于仅存在R-对映体,其副作用可能较少——尽管这一点尚未得到正式证实。口服和肠外给药后,由于(a) β-2选择性并非绝对,以及(b) 在这些给药途径下,沙丁胺醇在这些受体区域的浓度更高,因此会刺激体内的β受体(包括β1和β2受体)。这导致β-1受体介导的心脏兴奋作用(尽管不如异丙肾上腺素那么强烈),以及β-2受体介导的外周血管扩张和低血压、骨骼肌震颤和子宫肌松弛作用。代谢紊乱,例如高胰岛素血症和高血糖症,也可能发生,但尚不清楚这些紊乱是由β1受体还是β2受体介导的。血清钾水平有下降的趋势。
*注: 文献方法仅供参考, InvivoChem并未独立验证这些方法的准确性
化学信息 & 存储运输条件
分子式
C13H21NO3
分子量
239.31
精确质量
239.152
CAS号
18559-94-9
相关CAS号
Salbutamol hemisulfate;51022-70-9;Salbutamol-d3;1219798-60-3;Salbutamol-d9;1173021-73-2;Salbutamol-d9 acetate;1781417-68-2
PubChem CID
2083
外观&性状
White to off-white solid powder
密度
1.2±0.1 g/cm3
沸点
433.5±40.0 °C at 760 mmHg
熔点
157-158ºC
闪点
159.5±17.9 °C
蒸汽压
0.0±1.1 mmHg at 25°C
折射率
1.566
LogP
0.01
tPSA
72.72
氢键供体(HBD)数目
4
氢键受体(HBA)数目
4
可旋转键数目(RBC)
5
重原子数目
17
分子复杂度/Complexity
227
定义原子立体中心数目
0
InChi Key
NDAUXUAQIAJITI-UHFFFAOYSA-N
InChi Code
NDAUXUAQIAJITI-UHFFFAOYSA-N
化学名
4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
别名
Salbutamol Albuterol Proventil Sultanol Aerolin Albuterol Sulfate Proventil Salbutamol Sultanol Ventolin
HS Tariff Code
2934.99.9001
存储方式

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

运输条件
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
溶解度数据
溶解度 (体外实验)
DMSO : ~100 mg/mL (~417.87 mM)
溶解度 (体内实验)
配方 1 中的溶解度: ≥ 2.5 mg/mL (10.45 mM) (饱和度未知) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。
例如,若需制备1 mL的工作液,可将100 μL 25.0 mg/mL澄清DMSO储备液加入到400 μL PEG300中,混匀;然后向上述溶液中加入50 μL Tween-80,混匀;加入450 μL生理盐水定容至1 mL。
*生理盐水的制备:将 0.9 g 氯化钠溶解在 100 mL ddH₂O中,得到澄清溶液。

配方 2 中的溶解度: ≥ 2.5 mg/mL (10.45 mM) (饱和度未知) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。
例如,若需制备1 mL的工作液,可将 100 μL 25.0 mg/mL澄清DMSO储备液加入900 μL 20% SBE-β-CD生理盐水溶液中,混匀。
*20% SBE-β-CD 生理盐水溶液的制备(4°C,1 周):将 2 g SBE-β-CD 溶解于 10 mL 生理盐水中,得到澄清溶液。

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配方 3 中的溶解度: ≥ 2.5 mg/mL (10.45 mM) (饱和度未知) in 10% DMSO + 90% Corn Oil (这些助溶剂从左到右依次添加,逐一添加), 澄清溶液。
例如,若需制备1 mL的工作液,可将 100 μL 25.0 mg/mL 澄清 DMSO 储备液加入到 900 μL 玉米油中并混合均匀。


请根据您的实验动物和给药方式选择适当的溶解配方/方案:
1、请先配制澄清的储备液(如:用DMSO配置50 或 100 mg/mL母液(储备液));
2、取适量母液,按从左到右的顺序依次添加助溶剂,澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明,并不一定代表此产品 的实际溶解配方):
10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline);
假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀/澄清;向上述体系中加入50 μL Tween-80,混合均匀/澄清;然后继续加入450 μL ddH2O (或 saline)定容至 1 mL;

3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例;
4、 如产品在配制过程中出现沉淀/析出,可通过加热(≤50℃)或超声的方式助溶;
5、为保证最佳实验结果,工作液请现配现用!
6、如不确定怎么将母液配置成体内动物实验的工作液,请查看说明书或联系我们;
7、 以上所有助溶剂都可在 Invivochem.cn网站购买。
制备储备液 1 mg 5 mg 10 mg
1 mM 4.1787 mL 20.8934 mL 41.7868 mL
5 mM 0.8357 mL 4.1787 mL 8.3574 mL
10 mM 0.4179 mL 2.0893 mL 4.1787 mL

1、根据实验需要选择合适的溶剂配制储备液 (母液):对于大多数产品,InvivoChem推荐用DMSO配置母液 (比如:5、10、20mM或者10、20、50 mg/mL浓度),个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;

2、如果您找不到您想要的溶解度信息,或者很难将产品溶解在溶液中,请联系我们;

3、建议使用下列计算器进行相关计算(摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等);

4、母液配好之后,将其分装到常规用量,并储存在-20°C或-80°C,尽量减少反复冻融循环。

计算器

摩尔浓度计算器可计算特定溶液所需的质量、体积/浓度,具体如下:

  • 计算制备已知体积和浓度的溶液所需的化合物的质量
  • 计算将已知质量的化合物溶解到所需浓度所需的溶液体积
  • 计算特定体积中已知质量的化合物产生的溶液的浓度
使用摩尔浓度计算器计算摩尔浓度的示例如下所示:
假如化合物的分子量为350.26 g/mol,在5mL DMSO中制备10mM储备液所需的化合物的质量是多少?
  • 在分子量(MW)框中输入350.26
  • 在“浓度”框中输入10,然后选择正确的单位(mM)
  • 在“体积”框中输入5,然后选择正确的单位(mL)
  • 单击“计算”按钮
  • 答案17.513 mg出现在“质量”框中。以类似的方式,您可以计算体积和浓度。

稀释计算器可计算如何稀释已知浓度的储备液。例如,可以输入C1、C2和V2来计算V1,具体如下:

制备25毫升25μM溶液需要多少体积的10 mM储备溶液?
使用方程式C1V1=C2V2,其中C1=10mM,C2=25μM,V2=25 ml,V1未知:
  • 在C1框中输入10,然后选择正确的单位(mM)
  • 在C2框中输入25,然后选择正确的单位(μM)
  • 在V2框中输入25,然后选择正确的单位(mL)
  • 单击“计算”按钮
  • 答案62.5μL(0.1 ml)出现在V1框中
g/mol

分子量计算器可计算化合物的分子量 (摩尔质量)和元素组成,具体如下:

注:化学分子式大小写敏感:C12H18N3O4  c12h18n3o4
计算化合物摩尔质量(分子量)的说明:
  • 要计算化合物的分子量 (摩尔质量),请输入化学/分子式,然后单击“计算”按钮。
分子质量、分子量、摩尔质量和摩尔量的定义:
  • 分子质量(或分子量)是一种物质的一个分子的质量,用统一的原子质量单位(u)表示。(1u等于碳-12中一个原子质量的1/12)
  • 摩尔质量(摩尔重量)是一摩尔物质的质量,以g/mol表示。
/

配液计算器可计算将特定质量的产品配成特定浓度所需的溶剂体积 (配液体积)

  • 输入试剂的质量、所需的配液浓度以及正确的单位
  • 单击“计算”按钮
  • 答案显示在体积框中
动物体内实验配方计算器(澄清溶液)
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶/难溶于水的化合物),不同的产品和批次配方组成不同,如对配方有疑问,可先联系我们提供正确的体内实验配方。此外,请注意这只是一个配方计算器,而不是特定产品的确切配方。
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+
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计算结果:

工作液浓度 mg/mL;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度,请首先与我们联系。

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

(1) 请确保溶液澄清之后,再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶;
            (2) 一定要按顺序加入溶剂 (助溶剂) 。

临床试验信息
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
CTID: NCT06473779
Phase: Phase 3    Status: Recruiting
Date: 2024-11-20
Study to Investigate Changes in Airway Inflammation, Symptoms, and Rescue Therapy Utilization With AIRSUPRA Compared to Albuterol as Needed in Adults With Mild Asthma
CTID: NCT06563102
Phase: Phase 4    Status: Recruiting
Date: 2024-11-12
Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis
CTID: NCT01799538
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-11-04
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
CTID: NCT06152653
Phase: Phase 4    Status: Recruiting
Date: 2024-10-22
A Safety and Efficacy Study of Mepolizumab in Subjects With Severe Asthma
CTID: NCT03562195
Phase: Phase 3    Status: Completed
Date: 2024-09-19
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Efficacy and Safety Study of Mepolizumab 100 Milligram (mg) Subcutaneous (SC) in Indian Participants Aged Greater Than or Equal to (>=) 18 Years With Severe Eosinophilic Asthma
CTID: NCT04276233
Phase: Phase 4    Status: Completed
Date: 2024-09-19


Efficacy of Intermittent Tiotropium in Early Childhood Wheezing
CTID: NCT03199976
Phase: Phase 4    Status: Terminated
Date: 2024-09-19
Cardiovascular Consequences of Inhaled Short-acting Beta-agonist Use
CTID: NCT06027606
Phase: Phase 1    Status: Recruiting
Date: 2024-09-19
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype
CTID: NCT04901715
PhaseEarly Phase 1    Status: Recruiting
Date: 2024-08-26
CIVETTA: Correlating Inflammatory Values of FEno, SympToms, SpuTum and Lung Function in Asthma
CTID: NCT06482294
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-07-03
Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women
CTID: NCT06426082
Phase: N/A    Status: Not yet recruiting
Date: 2024-05-23
Treating Exacerbations of Asthma With Oral Montelukast in Children
CTID: NCT05819541
Phase: Phase 2    Status: Recruiting
Date: 2024-05-14
Insulin Dextrose Infusion vs Nebulized Salbutamol vs Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia
CTID: NCT04012138
Phase: Phase 4    Status: Recruiting
Date: 2024-04-30
Secondhand Smoke Respiratory Health Study
CTID: NCT02797275
Phase: Phase 4    Status: Active, not recruiting
Date: 2024-04-23
the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial)
CTID: NCT05527704
Phase: Phase 3    Status: Recruiting
Date: 2024-04-18
Effect of Salbutamol on Walking Capacity in Ambulatory ALS Patients
CTID: NCT05860244
Phase: Phase 2    Status: Not yet recruiting
Date: 2024-04-12
The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome
CTID: NCT05667727
Phase: Phase 4    Status: Recruiting
Date: 2024-04-09
Nebulized Salbutamol in Acute Renal Colic
CTID: NCT06276231
Phase: N/A    Status: Not yet recruiting
Date: 2024-03-19
The Regulatory Function of Inhaled Asthma Medication Salbutamol on Thermogenesis
CTID: NCT06319183
PhaseEarly Phase 1    Status: Not yet recruiting
Date: 2024-03-19
Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)
CTID: NCT03137303
Phase: Phase 3    Status: Completed
Date: 2024-02-26
Role of Parasympathetic Activity in Mild to Severe Asthma With Fixed Airway Obstruction (PARASMA Study)
CTID: NCT05550402
Phase: N/A    Status: Recruiting
Date: 2024-02-20
Video Assisted Study of Salbutamol Response in Viral Wheezing
CTID: NCT06093152
Phase:    Status: Recruiting
Date: 2024-01-22
CF Bronchodilation
CTID: NCT03522831
Phase: N/A    Status: Active, not recruiting
Date: 2023-12-14
Comparison of Preoperative Inhaled Budesonide With Salbutamol on the Respiratory Adverse Effects in Children Undergoing Tonsillectomy
CTID: NCT06158893
Phase: Phase 4    Status: Not yet recruiting
Date: 2023-12-06
Utilizing Exhaled Breathe Condensate Collection to Study Ion Regulation in Cystic Fibrosis
CTID: NCT01880723
Phase: N/A    Status: Completed
Date: 2023-11-29
INhaled Salbutamol vs Placebo for the Treatment of Acute IgE-mediated Abdominal Pain From Allergic Food REactions
CTID: NCT05653024
Phase: Phase 3    Status: Recruiting
Date: 2023-11-29
Mechanisms for Dyspnea on Exertion in Children With Obesity and Asthma: Distinct Physiological Phenotypes
CTID: NCT04184609
Phase: Phase 4    Status: Withdrawn
Date: 2023-11-07
5 Versus 10 Units of Insulin in Hyperkalemia Management
CTID: NCT06036823
Phase: Phase 4    Status: Recruiting
Date: 2023-10-03
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Salbutamol vs Long-acting Muscarinic Antagonists
CTID: NCT05457868
Phase:    Status: Active, not recruiting
Date: 2023-07-18
Evaluating Bronchodilator Response in Patients With Bronchiectasis
CTID: NCT05932316
Phase: N/A    Status: Recruiting
Date: 2023-07-06
Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)
CTID: NCT05087693
Phase: Phase 4    Status: Recruiting
Date: 2023-05-10
Different Doses of Nebulized Magnesium Sulphate in Status Asthmaticus
CTID: NCT04929626
Phase: Phase 1    Status: Completed
Date: 2023-04-05
A 24-Week Treatment Study to Compare Standard of Care Versus the eMDPI DS in Participants 13 Years or Older With Asthma
CTID: NCT04677959
Phase: Phase 4    Status: Completed
Date: 2023-03-14
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
CTID: NCT01721291
Phase: Phase 4    Status: Completed
Date: 2023-03-06
The Effect of NAC on Lung Function and CT Mucus Score
CTID: NCT03822637
Phase: Phase 4    Status: Recruiting
Date: 2023-02-10
Study of Dose-response to Bronchodilator and Dose-finding in Child 2.5 to 6 Years - Study Golden
CTID: NCT01470755
Phase: Phase 2    Status: Completed
Date: 2023-02-06
A 12-Week Treatment Study to Evaluate the Effectiveness of Albuterol Multidose Dry Powder Inhaler With Integrated Electronic Module Digital System (eMDPI DS) in Participants13 Years or Older With Asthma
CTID: NCT03890666
Phase: Phase 4    Status: Completed
Date: 2022-12-07
Phosphodiesterase 4 Gene Variant and Salbutamol Response in Persistent Childhood Asthma
CTID: NCT03592212
Phase:    Status: Unknown status
Date: 2022-11-01
Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion During Liver Transplantation
CTID: NCT05589441
Phase: N/A    Status: Unknown status
Date: 2022-10-21
Nebulized Epinephrine vs. Salbutamol in Bronchiolitis Among Children
CTID: NCT03814954
Phase: N/A    Status: Completed
Date: 2022-08-30
The Effects of Salbutamol on Mannitol Induced Cough Responses in Healthy Controls
CTID: NCT04565847
Phase: Phase 2    Status: Completed
Date: 2022-06-16
Chronic-Dose Safety and Efficacy Study of Albuterol-HFA-BAI in Pediatric Asthmatics
CTID: NCT00308685
Phase: Phase 3    Status: Completed
Date: 2022-04-01
Levalbuterol Compared to Albuterol Regarding Cardiac Side Effects and Potassium Lowering Effects.
CTID: NCT05173584
Phase: Phase 4    Status: Unknown status
Date: 2021-12-30
Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle
CTID: NCT04558190
Phase: N/A    Status: Completed
Date: 2021-12-02
Albuterol HFA MDI in Pediatric Participants With Asthma
CTID: NCT00577655
Phase: Phase 3    Status: Completed
Date: 2021-11-12
Anti-IgE Monoclonal Antibody Treatment in Patients With Allergic Asthma.
CTID: NCT03468790
Phase: Phase 3    Status: Completed
Date: 2021-10-11
Effect of Inhaled Albuterol in Pulmonary Hypertension
CTID: NCT03270332
Phase: Phase 2    Status: Completed
Date: 2021-08-30
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN)
CTID: NCT05006235
Phase: Phase 1    Status: Completed
Date: 2021-08-16
Albuterol and Immune Cell Composition
CTID: NCT03889379
PhaseEarly Phase 1    Status: Withdrawn
Date: 2021-08-13
Bronchodilators for Wheeze in Young Children Presenting to Primary Care: a Randomised, Placebo-controlled, Multicentre, Parallel Group Trial
CTID: NCT04584034
Phase: Phase 4    Status: Withdrawn
Date: 2021-07-23
A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled ETD002 in Healthy Subjects
CTID: NCT04488705
Phase: Phase 1    Status: Completed
Date: 2021-05-21
Comparison of Breath-Enhanced and T-Piece Nebulizers in Children With Acute Asthma
CTID: NCT02566902
Phase: N/A    Status: Completed
Date: 2021-05-06
A Clinical Study to Evaluate the Effect of the Connected Inhaler System (CIS) on Adherence to Maintenance Therapy in Poorly Controlled Asthmatic Subjects
CTID: NCT03380429
Phase: Phase 4    Status: Completed
Date: 2021-04-12
Comparison of Nebulizers in ED in Pediatric Asthma Patients
CTID: NCT01951378
Phase: Phase 4    Status: Terminated
Date: 2021-04-08
Effect of Fluticasone Furoate/Vilanterol on EIA in Adolescents
CTID: NCT04750603
Phase: Phase 4    Status: Completed
Date: 2021-02-11
The Development of Novel Clinical Tests to Diagnose and Monitor Asthma in Preschool Children
CTID: NCT02743663
Phase:    Status: Completed
Date: 2021-02-08
Sensor and Electronic Health Records (EHR) Integration Pilot Study
CTID: NCT03357341
Phase:    Status: Completed
Date: 2020-11-24
Physiologic Performance Response to Salbutamol
CTID: NCT04615611
Phase: N/A    Status: Unknown status
Date: 2020-11-04
Physiological Response to Salbutamol and Exercise
CTID: NCT03902106
Phase: N/A    Status: Unknown status
Date: 2020-11-03
Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults
CTID: NCT02802111
Phase: N/A    Status: Completed
Date: 2020-10-28
Efficacy and Safety of Nebulised Beclomethasone Dipropionate Plus as Needed Salbutamol vs as Needed Salbutamol or as Needed Salbutamol/Beclomethasone Fixed Combination in Young Children With Asthma Symptoms
CTID: NCT00497523
Phase: Phase 3    Status: Completed
Date: 2020-08-03
As Needed Beclomethasone/Salbutamol Combination in Single Inhaler for Mild Persistent Asthma
CTID: NCT00382889
Phase: Phase 3    Status: Completed
Date: 2020-08-03
Status Asthmaticus on the PICU; Intravenous Salbutamol
CTID: NCT03493503
Phase: Phase 4    Status: Completed
Date: 2020-07-30
Batefenterol/Fluticasone Furoate in Treatment of Chronic Obstructive Pulmonary Disease
CTID: NCT02573870
Phase: Phase 2    Status: Completed
Date: 2020-07-21
A Long-term Safety Study of Fixed Dose Combination Therapy Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate in Japanese Subjects With Asthma
CTID: NCT03184987
Phase: Phase 3    Status: Completed
Date: 2020-05-29
Beta-agonist Efficacy and Tolerability as Adjuvant Therapy in Myasthenia Gravis
CTID: NCT03914638
Phase: Phase 2/Phase 3    Status: Unknown status
Date: 2020-04-06
Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease
CTID: NCT00440245
Phase: Phase 4    Status: Completed
Date: 2020-03-27
Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma
CTID: NCT03620422
Phase: N/A    Status: Completed
Date: 2020-02-17
A Study of the Efficacy and Safety of NVA237 in Patients With Moderate to Severe COPD
CTID: NCT02371629
Phase: Phase 4    Status: Completed
Date: 2019-08-09
Assessment of the Safety, Efficacy, PK, and Extrapulmonary Pharmacodynamics (PD) of Albuterol Sulfate Pressurized Inhalation Suspension (Hereafter Referred to as AS MDI) Compared to Proventil as an Active Control in Subjects With Asthma
CTID: NCT03371459
Phase: Phase 2    Status: Completed
Date: 2019-07-23
Effects of Noninvasive Ventilation Compared to Salbutamol
CTID: NCT03430505
Phase: N/A    Status: Completed
Date: 2019-07-22
Safety and Efficacy of Albuterol in Individuals With Late-onset Pompe Disease
CTID: NCT01885936
Phase: Phase 1/Phase 2    Status: Completed
Date: 2019-07-15
Albuterol in Individuals With Late Onset Pompe Disease (LOPD)
CTID: NCT01859624
Phase: Phase 1    Status: Completed
Date: 2019-07-05
Repeat Emergency Department Visits Among Patients With Asthma and COPD
CTID: NCT02499887
Phase: N/A    Status: Terminated
Date: 2019-06-04
Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus
CTID: NCT02872597
Phase: Phase 1    Status: Completed
Date: 2019-04-18
Trough Bronchoprotection Conferred by Levosalbutamol and Racemic Salbutamol
CTID: NCT00831376
Phase: Phase 4    Status: Completed
Date: 2019-04-12
------------------
‘Bronchodilators for wheeze in young children presenting to primary care: a randomised, placebo-controlled, multicentre, parallel group trial’
CTID: null
Phase: Phase 4    Status: Prematurely Ended, Ongoing
Date: 2020-07-08
Congenital myopathy intervention study
CTID: null
Phase: Phase 4    Status: Trial now transitioned
Date: 2020-03-31
Salbutamol for analgesia in renal colic: A prospective, randomised, placebo controlled Phase II trial
CTID: null
Phase: Phase 2, Phase 4    Status: GB - no longer in EU/EEA
Date: 2019-07-08
A 12-week, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group, Phase III Study Evaluating the Efficacy and Safety of PT027 Compared to PT008 and PT007 Administered QID in Adults and Children 4 Years of Age or Older with Asthma (DENALI)
CTID: null
Phase: Phase 3    Status: Completed
Date: 2019-06-26
Beta-agonist Efficacy and Tolerability as Adjuvant therapy in Myasthenia Gravis
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2019-03-28
In vivo efficacy of Salbutamol Sandoz versus salbutamol Ventolin GSK in children with asthma
CTID: null
Phase: Phase 4    Status: Completed
Date: 2018-08-08
A clinical study to assess the feasibility of measuring inhaled medication concentrations in exhaled breath condensate obtained from healthy volunteers and asthma patients and to assess the relationship with clinical endpoints
CTID: null
Phase: Phase 2    Status: Completed
Date: 2017-12-20
A double blind, placebo controlled, randomised dose escalation trial to investigate the safety and efficacy of topical salbutamol in the improvement of scar appearance when applied to approximated wound margins in healthy volunteers.
CTID: null
Phase: Phase 1, Phase 2    Status: Completed
Date: 2017-10-31
Pharmacological effects of acute and accumulated salbutamol in relation to doping analysis
CTID: null
Phase: Phase 2    Status: Completed
Date: 2016-12-14
The pulmonary effect of bronchodilation on adult VSD patients with persistent or surgically corrected VSD
CTID: null
Phase: Phase 4    Status: Completed
Date: 2016-08-15
β2-mimétiques et système nerveux central : effets du salbutamol sur l’excitabilité corticale et l’activation cérébrale (Betactiv)
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2016-07-06
Effect of bronchodilators on effort induced dyspnoea in patients suffering
CTID: null
Phase: Phase 3    Status: Completed
Date: 2016-02-11
Efficacy of Intermittent Tiotropium in Early Childhood Wheezing
CTID: null
Phase: Phase 4    Status: Completed
Date: 2015-11-18
A phase II, randomised, double blind, placebo controlled, six way crossover study to assess the bronchodilator effect of RPL554 administered on top of salbutamol and ipratropium in patients with COPD
CTID: null
Phase: Phase 2    Status: Completed
Date: 2015-09-18
A B2-agonist as a CFTR activator in CF - Part 2
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2015-07-30
Optimising effectiveness and minimising toxicity of intravenous salbutamol in children with acute asthma
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2015-02-02
A randomised, double-blind, placebo-controlled, parallel-group, multi-centre 24-week study to evaluate the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe eosinophilic asthma on markers of asthma control
CTID: null
Phase: Phase 3    Status: Completed
Date: 2014-11-19
Effect of Dual Bronchodilatation on Broncholysis Testing in COPD Patients
CTID: null
Phase: Phase 4    Status: Completed
Date: 2014-09-23
A Phase III, 24 week, randomized, double blind, double dummy, parallel group study (with an extension to 52 weeks in a subset of subjects) comparing the efficacy, safety and tolerability of the fixed dose triple combination FF/UMEC/VI administered once-daily in the morning via a dry powder inhaler with budesonide/formoterol 400mcg/12mcg administered twice-daily via a reservoir inhaler in subjects with chronic obstructive pulmonary disease.
CTID: null
Phase: Phase 3    Status: Completed
Date: 2014-09-16
A B2-agonist as a CFTR activator in CF
CTID: null
Phase: Phase 2    Status: Completed
Date: 2014-04-30
A prospective, multicenter, 12-week, randomized open-label study to evaluate the efficacy and safety of glycopyrronium (50 micrograms o.d.) or indacaterol maleate and glycopyrronium bromide fixed-dose combination (110/50 micrograms o.d.) regarding symptoms and health status in patients with moderate chronic obstructive pulmonary disease (COPD) switching from treatment with any standard COPD regimen
CTID: null
Phase: Phase 4    Status: Completed
Date: 2014-02-26
Reversibility of pulmonary function after inhaling salbutamol in different doses in standard and forward leaning body posture in asthmatic children
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2013-11-07
The protective effect of a single dose salbutamol against exercise induced inspiratory airflow obstruction in asthmatic children.
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2013-09-04
The influence of exercise and hydration to the pharmacological response to inhaled terbutalin and salbutamol in men
CTID: null
Phase: Phase 4    Status: Completed
Date: 2013-07-17
Inhaled salbutamol in elective caesarean section
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2012-11-09
The effect of cold air on the airways of elite skaters and the protective role of the OMRON
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2012-10-29
The effects of high dose beta2-agonists on physical performance in healthy male subjects
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2012-09-10
A Phase IV, open-label, prospective, randomised clinical trial to evaluate the usefulness of measuring nitric oxide in exhaled air in the therapeutic management of adult patients with mild asthma
CTID: null
Phase: Phase 4    Status: Completed
Date: 2012-07-23
A 4-Week Randomized Cross-Over Study to Evaluate Daily Lung Function Following the Administration of Albuterol/Salbutamol and Ipratropium in Subjects with Chronic Obstructive Pulmonary Disease
CTID: null
Phase: Phase 4    Status: Completed
Date: 2012-06-18
A PHASE IIA, RANDOMISED, SINGLE DOSE, DOUBLE-BLIND, DOUBLE-DUMMY, 6 WAY COMPLETE CROSS-OVER, PLACEBO CONTROLLED CLINICAL TRIAL TO ASSESS THE EFFICACY, SAFETY AND TOLERABILITY OF 4 DOSES OF LAS100977 QD COMPARED TO PLACEBO AND AN ACTIVE COMPARATOR IN PATIENTS WITH PERSISTENT ASTHMA
CTID: null
Phase: Phase 2    Status: Completed
Date: 2011-08-01
Essai prospectif randomisé, en double aveugle, comparant la Nalbuphine à l'association Hydroxyzine-Salbutamol dans la dystocie de démarrage.
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2010-11-03
Does nebulised hypertonic (3%) saline reduce the duration of hospital admission in infants with bronchiolitis?
CTID: null
Phase: Phase 4    Status: Completed
Date: 2010-05-13
Diagnostic et traitement de l'asthme chez le sportif : la frontière entre la pathologie et le dopage
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2010-02-05
BISOPROLOLIN VAIKUTUS HEMODYNAMIIKKAAN LIEVÄSTI TAI KOHTALAISESTI HYPERTENSIIVISILLÄ MIEHILLÄ: KAKSOISSOKKO, VAIHTOVUOROINEN LUMEKONTROLLOITU TUTKIMUS
CTID: null
Phase: Phase 4    Status: Completed
Date: 2009-11-12
Blood- and urinary concentrations of salbutamol in asthmatics and elite athletes with asthma; comparison between inhalation vs. oral administration.
CTID: null
Phase: Phase 4    Status: Completed
Date: 2009-05-11
Aerosolised salbutamol in two doses as a treatment for preterm infants with developing bronchopulmonary dysplasia.
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2009-03-19
A proof of concept study to evaluate rebound trough airway hyper-responsiveness after single and chronic dosing with levosalbutamol and racemic salbutamol in persistent asthmatics
CTID: null
Phase: Phase 4    Status: Completed
Date: 2009-02-04
Effect of fixed combination of beclomethasone dipropionate/formoterol fumarate (BDP/FF), as reliever, upon exhaled nitric oxide in asthma. FENOMENO study (Fractional Exhaled Nitric Oxide-Multiple Expiration flow of NO). A single-centre, placebo controlled, randomized, double blind, cross-over study
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2008-12-04
Ipratropio bromuro-albuterol association vs salbutamolo in asthma and gastroesophageal reflux
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2008-10-07
A proof of concept study to evaluate the peak bronchoprotection conferred by single and chronic dosing with levosalbutamol and racemic salbutamol in persistent asthmatics.
CTID: null
Phase: Phase 4    Status: Completed
Date: 2008-09-01
A single dose, randomized, double blind, double dummy, placebo controlled, three-period crossover clinical study, comparing the onset of relief from methacholine induced bronchoconstriction with fixed combination beclomethasone dipropionate 100 μg plus formoterol fumarate 6 μg/actuation pMDI with HFA-134a propellant (Foster®) versus standard salbutamol pMDI 100 μg/actuation (Ventolin® 100 μg) therapy in asthmatic patients
CTID: null
Phase: Phase 2    Status: Completed
Date: 2008-08-20
A PHASE II RANDOMIZED, DOUBLE-BLIND STUDY VS. PLACEBO FOR THE EVALUATION OF EFFICACY AND TOLERABILITY OF SALBUTAMOL ADMINISTERED BY ORAL ROUTE IN PATIENTS AFFECTED BY SPINAL MUSCULAR ATHROPHY.
CTID: null
Phase: Phase 2    Status: Completed
Date: 2008-07-29
A phase III, randomized, double-blind, triple-dummy, placebo controlled, multicenter, 5- period, single-dose complete block crossover study to determine the onset of action of indacaterol (150 and 300 μg) in patients with moderate to severe COPD using salbutamol (200 μg) and salmeterol/fluticasone (50/500 μg) as active controls.
CTID: null
Phase: Phase 3    Status: Completed
Date: 2008-04-09
A randomised, double-blind, crossover study to investigate the bronchodilatation post-inhalation of GSK961081 alone and with the addition of cumulative doses of short acting bronchodilators (salbutamol and ipratropium bromide) in patients with COPD
CTID: null
Phase: Phase 2    Status: Completed
Date: 2008-04-03
Influence of tiotropium bromide (Spiriva ®) plus salbutamol versus salbutamol on the mucin secretion and sputum properties in subjects with a COPD exacerbation
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2007-12-07
Chemoreflex sensitivity, exercise and beta agonists
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2007-08-30
A SINGLE CENTRE, GAMMA SCINTIGRAPHY STUDY IN ASTHMATIC PATIENTS TO COMPARE PULMONARY DEPOSITION AND PHARMACOKINETICS OF ALBUTEROL INHALATION SOLUTION (AIS) DELIVERED VIA eFLOW NEBULISER AND SALBUTAMOL NEBULISER SOLUTION VIA LC PLUS NEBULISER
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2007-02-21
Ensayo clínico piloto, aleatorizado, controlado con placebo, paralelo, doble ciego, para evaluar el efecto de salbutamol intravenoso sobre marcadores de inflamación en pacientes con síndrome de distrés respiratorio agudo
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2006-07-07
Effect of Oxis on the Efficacy of Mucociliary Clearance in Patients with COPD
CTID: null
Phase: Phase 4    Status: Completed
Date: 2005-04-14
A randomised, placebo-controlled, double-blind, double-dummy, crossover study to assess the onset of action of two inhalations of Symbicort 160/4.5μg compared with two inhalations of Seretide 25/250μg, two inhalations of Ventoline 100μg, and placebo, delivered by pressurised metered dose inhalers, in patients with chronic obstructive pulmonary disease (COPD).
CTID: null
Phase: Phase 3    Status: Completed
Date: 2004-10-08
How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children?
CTID: null
Phase: Phase 4    Status: Completed
Date:
A 12-week, randomised, double-blind, placebo-controlled, parallel group, multinational, phase IIb dose range finding study to evaluate the efficacy and safety of AZD9668 administered orally at 3 dose levels to patients with Chronic Obstructive Pulmonary Disease (COPD) on treatment with tiotropium
CTID: null
Phase: Phase 2    Status: Completed
Date:
A 48-week, multicentre, multinational, randomized, double-blind, 2-arm parallel group study, comparing the efficacy of FOSTER™ for maintenance and reliever versus fixed-dose FOSTER™ for maintenance + salbutamol as reliever in asthmatics ≥18 years of age
CTID: null
Phase: Phase 3    Status: Completed
Date:
A Long-term, Randomized, Double-blind, Multicenter, Parallel-group, Phase III Study Evaluating the Efficacy and Safety of PT027 Compared to PT007 Administered as Needed in Response to Symptoms in Symptomatic Adults and Children 4 Years of Age or Older with Asthma (MANDALA).
CTID: null
Phase: Phase 3    Status: Ongoing, Completed, GB - no longer in EU/EEA
Date:
Etude de la dose-réponse au bronchodilatateur puis recherche de dose du bronchodilatateur par la technique de l'interruption du débit chez l'enfant siffleur âgé de 2,5 à 6 ans - Etude DORESI.
CTID: null
Phase: Phase 4    Status: Ongoing
Date:

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