Description:LY2584702 Tosylate (also known as LYS6K2), the tosylate salt of LY2584702, is a selective, orally bioavailable, and ATP-competitive p70S6K
(ribosomal p70 S6 kinase) inhibitor with potential antitumor activity. It inhibits p70S6K with
an IC50 of 4 nM. LY2584702 showed potent antiproliferative activity in
vitro and high antitumor efficacy in vivo by inhibiting ribosomal
protein S6 Kinase (p70S6K), and preventing phosphorylation of the S6
subunit of ribosomes, thereby inhibiting normal ribosomal function
within tumor cells leading to a decrease in protein synthesis and in
cellular proliferation.
References: Eur J Cancer. 2014 Mar;50(5):867-75; Eur J Cancer. 2014 Mar;50(5):876-84.
Related CAS: 1082949-67-4 (free base); 1082948-81-9 (HCl); 1082949-68-5 (tosylate)