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    IN04
    IN04

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    产品仅用于科学研究,不针对患者销售
    数量: - + 件(库存件)
    InvivoChem目录号 #: V22210
    CAS号码 #: 838816-57-2纯度 ≥98%

    Description: IN04, also know as Methyl 3-(2-((5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)benzoate, is a novel and potent inhibitor of Leucine rich repeat kinase 1 (LRRK1), suppressing osteoclasts (OC) function with no effect on OC formation. IN04 inhibits LRRK1 by binding to the active site of the kinase domain but not the ROC domain. LRRK1 plays a critical role in regulating OC function and peak bone mass. Therefore, LRRK1 is a novel drug target for alternative anti-resorptive drugs to treat osteoporosis and osteoporotic fractures.

    References:  Aging (Albany NY)  . 2019 May 21;11(10):3250-3261. doi: 10.18632/aging.101977. 

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    Molecular Formula: C20H19N3O6S
    Exact Mass: 429.0995
    Molecular Weight: 429.447

    Synonym: IN04; IN 04; IN-04;


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