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Description: IN04, also know as Methyl 3-(2-((5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)benzoate, is a novel and potent inhibitor of Leucine rich repeat kinase 1 (LRRK1), suppressing osteoclasts (OC) function with no effect on OC formation. IN04 inhibits LRRK1 by binding to the active site of the kinase domain but not the ROC domain. LRRK1 plays a critical role in regulating OC function and peak bone mass. Therefore, LRRK1 is a novel drug target for alternative anti-resorptive drugs to treat osteoporosis and osteoporotic fractures.
References: Aging (Albany NY) . 2019 May 21;11(10):3250-3261. doi: 10.18632/aging.101977.
2023-2024产品目录
产品使用说明书(通用型)
Molecular Formula: C20H19N3O6S Exact Mass: 429.0995 Molecular Weight: 429.447
Synonym: IN04; IN 04; IN-04;
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Lot#: V2221001,Purity ≥98%
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