Hydroxychloroquine

别名: 硫酸羟氯喹;羟氯喹;羟基氯喹;2-[[4-[(7-氯喹啉-4-基)氨基]戊基](乙基)氨基]乙醇;崖柏酮
目录号: V50883 纯度: ≥98%
羟氯喹是一种合成抗疟药,还可抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。
Hydroxychloroquine CAS号: 118-42-3
产品类别: New3
产品仅用于科学研究,不针对患者销售
规格 价格 库存 数量
100mg
250mg
500mg
Other Sizes

Other Forms of Hydroxychloroquine:

  • (S)-Hydroxychloroquine sulfate
  • 硫酸羟基氯喹
  • Hydroxychloroquine-d4-1 sulfate (羟氯喹 d4 (硫酸盐) (烷基上氘))
  • Hydroxychloroquine-d5 (hydroxychloroquine-d5; hydroxychloroquine-d5)
点击了解更多
InvivoChem产品被CNS等顶刊论文引用
产品描述
羟氯喹是一种合成抗疟药,还可抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。羟氯喹可有效抑制 SARS-CoV-2 感染。
生物活性&实验参考方法
药代性质 (ADME/PK)
吸收、分布和排泄
羟氯喹的生物利用度为67-74%。R和S对映异构体的生物利用度无显著差异。健康男性志愿者单次口服200 mg羟氯喹后,全血羟氯喹Cmax为129.6 ng/mL(血浆Cmax为50.3 ng/mL),Tmax为3.3小时(血浆Tmax为3.7小时)。单次口服200 mg羟氯喹后,平均吸收分数为0.74(与静脉输注155 mg羟氯喹相比)。代谢物的血药峰浓度与羟氯喹的血药峰浓度同时出现。单次静脉注射155 mg和310 mg后,155 mg输注后和310 mg输注后6个月的血药峰浓度范围为1161 ng/mL至2436 ng/mL(平均1918 ng/mL)。在155 mg和310 mg的治疗剂量范围内,药代动力学参数无显著差异,表明其呈线性药代动力学特征。在类风湿性关节炎患者中,药物吸收率差异较大(即30%至100%),且疾病活动度较低的患者的平均羟氯喹水平显著更高。40-50%的羟氯喹经肾脏排泄,而仅有16-21%的剂量以原形药物的形式经尿液排出。 5%的剂量经皮肤脱落,24-25%经粪便排出。
羟氯喹广泛分布于组织中;其在血液中的分布容积为5522升,在血浆中的分布容积为44257升。
羟氯喹的清除率为96毫升/分钟。原药的肾清除率约为16%至30%。
代谢/代谢物
羟氯喹经CYP3A4进行N-去烷基化,生成活性代谢物去乙基羟氯喹以及非活性代谢物去乙基氯喹和双去乙基氯喹。去乙基羟氯喹是主要代谢物。
部分经肝脏代谢为活性去乙基化代谢物。
半衰期:血液中的末端消除半衰期约为50天。在血浆中,半衰期约为 32 天。
生物半衰期
健康男性志愿者单次口服 200 mg 羟氯喹后,血浆半衰期为 123.5 天。3 个月后,尿液中仍可检测到羟氯喹,约 10% 的剂量以原药形式排出。单次服用 200 mg 片剂与静脉输注(155 mg)的结果显示,半衰期约为 40 天,且分布容积较大。长期口服羟氯喹后,吸收半衰期约为 3 至 4 小时,末端半衰期为 40 至 50 天。
毒性/毒理 (Toxicokinetics/TK)
毒性概述
虽然羟氯喹的确切作用机制尚不清楚,但可能与其结合并改变DNA的能力有关。研究发现,羟氯喹还能被红细胞内寄生虫的酸性食物泡吸收。这会提高酸性囊泡的pH值,干扰囊泡功能,并可能抑制磷脂代谢。在抑制治疗中,羟氯喹可抑制疟原虫在红细胞内的发育阶段。在疟疾急性发作期间,它能阻断寄生虫在红细胞内的裂殖生殖。羟氯喹在受感染的红细胞中富集的能力可能解释了其对疟原虫感染红细胞阶段的选择性毒性。作为一种抗风湿药,羟氯喹被认为具有轻度免疫抑制作用,可抑制类风湿因子和急性期反应物的产生。它还会在白细胞中积聚,稳定溶酶体膜,抑制许多酶的活性,包括胶原酶和导致软骨分解的蛋白酶。
其他信息
药效学
羟氯喹可影响人体和疟原虫溶酶体的功能。改变溶酶体的pH值可减少自身免疫性疾病中低亲和力自身抗原的呈递,并干扰疟原虫水解血红蛋白以满足其能量需求的能力。羟氯喹作用持续时间长,某些适应症可每周服用一次。羟氯喹可能导致严重低血糖,因此建议糖尿病患者监测血糖水平。羟氯喹对氯喹敏感的恶性疟原虫、三日疟原虫、间日疟原虫和卵形疟原虫的红细胞期均有效。羟氯喹对间日疟原虫和卵形疟原虫的配子体和红细胞外期(包括休眠子肝期)无效。在已报告氯喹耐药性的地区,羟氯喹对疟疾无效。
*注: 文献方法仅供参考, InvivoChem并未独立验证这些方法的准确性
化学信息 & 存储运输条件
分子式
C18H26N3OCL
分子量
335.87154
精确质量
335.176
CAS号
118-42-3
相关CAS号
Hydroxychloroquine sulfate;747-36-4;Hydroxychloroquine-d4-1 sulfate;1216432-56-2;Hydroxychloroquine-d5
PubChem CID
3652
外观&性状
White to off-white solid powder
密度
1.176 g/cm3
沸点
516.7ºC at 760 mmHg
熔点
89-91°
闪点
266.3ºC
蒸汽压
1.68E-11mmHg at 25°C
折射率
1.5790 (estimate)
LogP
3.856
tPSA
48.39
氢键供体(HBD)数目
2
氢键受体(HBA)数目
4
可旋转键数目(RBC)
9
重原子数目
23
分子复杂度/Complexity
331
定义原子立体中心数目
0
SMILES
CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
InChi Key
XXSMGPRMXLTPCZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
化学名
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
HS Tariff Code
2934.99.9001
存储方式

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

运输条件
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
溶解度数据
溶解度 (体外实验)
DMSO : ≥ 100 mg/mL (~297.73 mM)
1M HCl : 100 mg/mL (~297.73 mM)
H2O : ~1.67 mg/mL (~4.97 mM)
溶解度 (体内实验)
注意: 如下所列的是一些常用的体内动物实验溶解配方,主要用于溶解难溶或不溶于水的产品(水溶度<1 mg/mL)。 建议您先取少量样品进行尝试,如该配方可行,再根据实验需求增加样品量。

注射用配方
(IP/IV/IM/SC等)
注射用配方1: DMSO : Tween 80: Saline = 10 : 5 : 85 (如: 100 μL DMSO 50 μL Tween 80 850 μL Saline)
*生理盐水/Saline的制备:将0.9g氯化钠/NaCl溶解在100 mL ddH ₂ O中,得到澄清溶液。
注射用配方 2: DMSO : PEG300Tween 80 : Saline = 10 : 40 : 5 : 45 (如: 100 μL DMSO 400 μL PEG300 50 μL Tween 80 450 μL Saline)
注射用配方 3: DMSO : Corn oil = 10 : 90 (如: 100 μL DMSO 900 μL Corn oil)
示例: 注射用配方 3 (DMSO : Corn oil = 10 : 90) 为例说明, 如果要配制 1 mL 2.5 mg/mL的工作液, 您可以取 100 μL 25 mg/mL 澄清的 DMSO 储备液,加到 900 μL Corn oil/玉米油中, 混合均匀。
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注射用配方 4: DMSO : 20% SBE-β-CD in Saline = 10 : 90 [如:100 μL DMSO 900 μL (20% SBE-β-CD in Saline)]
*20% SBE-β-CD in Saline的制备(4°C,储存1周):将2g SBE-β-CD (磺丁基-β-环糊精) 溶解于10mL生理盐水中,得到澄清溶液。
注射用配方 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (如: 500 μL 2-Hydroxypropyl-β-cyclodextrin (羟丙基环胡精) 500 μL Saline)
注射用配方 6: DMSO : PEG300 : Castor oil : Saline = 5 : 10 : 20 : 65 (如: 50 μL DMSO 100 μL PEG300 200 μL Castor oil 650 μL Saline)
注射用配方 7: Ethanol : Cremophor : Saline = 10: 10 : 80 (如: 100 μL Ethanol 100 μL Cremophor 800 μL Saline)
注射用配方 8: 溶解于Cremophor/Ethanol (50 : 50), 然后用生理盐水稀释。
注射用配方 9: EtOH : Corn oil = 10 : 90 (如: 100 μL EtOH 900 μL Corn oil)
注射用配方 10: EtOH : PEG300Tween 80 : Saline = 10 : 40 : 5 : 45 (如: 100 μL EtOH 400 μL PEG300 50 μL Tween 80 450 μL Saline)


口服配方
口服配方 1: 悬浮于0.5% CMC Na (羧甲基纤维素钠)
口服配方 2: 悬浮于0.5% Carboxymethyl cellulose (羧甲基纤维素)
示例: 口服配方 1 (悬浮于 0.5% CMC Na)为例说明, 如果要配制 100 mL 2.5 mg/mL 的工作液, 您可以先取0.5g CMC Na并将其溶解于100mL ddH2O中,得到0.5%CMC-Na澄清溶液;然后将250 mg待测化合物加到100 mL前述 0.5%CMC Na溶液中,得到悬浮液。
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口服配方 3: 溶解于 PEG400 (聚乙二醇400)
口服配方 4: 悬浮于0.2% Carboxymethyl cellulose (羧甲基纤维素)
口服配方 5: 溶解于0.25% Tween 80 and 0.5% Carboxymethyl cellulose (羧甲基纤维素)
口服配方 6: 做成粉末与食物混合


注意: 以上为较为常见方法,仅供参考, InvivoChem并未独立验证这些配方的准确性。具体溶剂的选择首先应参照文献已报道溶解方法、配方或剂型,对于某些尚未有文献报道溶解方法的化合物,需通过前期实验来确定(建议先取少量样品进行尝试),包括产品的溶解情况、梯度设置、动物的耐受性等。

请根据您的实验动物和给药方式选择适当的溶解配方/方案:
1、请先配制澄清的储备液(如:用DMSO配置50 或 100 mg/mL母液(储备液));
2、取适量母液,按从左到右的顺序依次添加助溶剂,澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明,并不一定代表此产品 的实际溶解配方):
10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline);
假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀/澄清;向上述体系中加入50 μL Tween-80,混合均匀/澄清;然后继续加入450 μL ddH2O (或 saline)定容至 1 mL;

3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例;
4、 如产品在配制过程中出现沉淀/析出,可通过加热(≤50℃)或超声的方式助溶;
5、为保证最佳实验结果,工作液请现配现用!
6、如不确定怎么将母液配置成体内动物实验的工作液,请查看说明书或联系我们;
7、 以上所有助溶剂都可在 Invivochem.cn网站购买。
制备储备液 1 mg 5 mg 10 mg
1 mM 2.9773 mL 14.8867 mL 29.7734 mL
5 mM 0.5955 mL 2.9773 mL 5.9547 mL
10 mM 0.2977 mL 1.4887 mL 2.9773 mL

1、根据实验需要选择合适的溶剂配制储备液 (母液):对于大多数产品,InvivoChem推荐用DMSO配置母液 (比如:5、10、20mM或者10、20、50 mg/mL浓度),个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;

2、如果您找不到您想要的溶解度信息,或者很难将产品溶解在溶液中,请联系我们;

3、建议使用下列计算器进行相关计算(摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等);

4、母液配好之后,将其分装到常规用量,并储存在-20°C或-80°C,尽量减少反复冻融循环。

计算器

摩尔浓度计算器可计算特定溶液所需的质量、体积/浓度,具体如下:

  • 计算制备已知体积和浓度的溶液所需的化合物的质量
  • 计算将已知质量的化合物溶解到所需浓度所需的溶液体积
  • 计算特定体积中已知质量的化合物产生的溶液的浓度
使用摩尔浓度计算器计算摩尔浓度的示例如下所示:
假如化合物的分子量为350.26 g/mol,在5mL DMSO中制备10mM储备液所需的化合物的质量是多少?
  • 在分子量(MW)框中输入350.26
  • 在“浓度”框中输入10,然后选择正确的单位(mM)
  • 在“体积”框中输入5,然后选择正确的单位(mL)
  • 单击“计算”按钮
  • 答案17.513 mg出现在“质量”框中。以类似的方式,您可以计算体积和浓度。

稀释计算器可计算如何稀释已知浓度的储备液。例如,可以输入C1、C2和V2来计算V1,具体如下:

制备25毫升25μM溶液需要多少体积的10 mM储备溶液?
使用方程式C1V1=C2V2,其中C1=10mM,C2=25μM,V2=25 ml,V1未知:
  • 在C1框中输入10,然后选择正确的单位(mM)
  • 在C2框中输入25,然后选择正确的单位(μM)
  • 在V2框中输入25,然后选择正确的单位(mL)
  • 单击“计算”按钮
  • 答案62.5μL(0.1 ml)出现在V1框中
g/mol

分子量计算器可计算化合物的分子量 (摩尔质量)和元素组成,具体如下:

注:化学分子式大小写敏感:C12H18N3O4  c12h18n3o4
计算化合物摩尔质量(分子量)的说明:
  • 要计算化合物的分子量 (摩尔质量),请输入化学/分子式,然后单击“计算”按钮。
分子质量、分子量、摩尔质量和摩尔量的定义:
  • 分子质量(或分子量)是一种物质的一个分子的质量,用统一的原子质量单位(u)表示。(1u等于碳-12中一个原子质量的1/12)
  • 摩尔质量(摩尔重量)是一摩尔物质的质量,以g/mol表示。
/

配液计算器可计算将特定质量的产品配成特定浓度所需的溶剂体积 (配液体积)

  • 输入试剂的质量、所需的配液浓度以及正确的单位
  • 单击“计算”按钮
  • 答案显示在体积框中
动物体内实验配方计算器(澄清溶液)
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶/难溶于水的化合物),不同的产品和批次配方组成不同,如对配方有疑问,可先联系我们提供正确的体内实验配方。此外,请注意这只是一个配方计算器,而不是特定产品的确切配方。
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+
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计算结果:

工作液浓度 mg/mL;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度,请首先与我们联系。

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

(1) 请确保溶液澄清之后,再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶;
            (2) 一定要按顺序加入溶剂 (助溶剂) 。

临床试验信息
Binimetinib and Hydroxychloroquine in Treating Patients with KRAS Mutant Metastatic Pancreatic Cancer
CTID: NCT04132505
Phase: Phase 1    Status: Active, not recruiting
Date: 2024-12-02
A Study of Nivolumab and Hydroxychloroquine or Nivolumab/Ipilimumab and Hydroxychloroquine in Advanced Melanoma
CTID: NCT04464759
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-11-21
Therapeutic Effect of Hydroxychloroquine on Immunoglobulin A (IgA) Nephropathy Course QUIgAN Study
CTID: NCT06350630
Phase: Phase 2    Status: Not yet recruiting
Date: 2024-11-19
Ulixertinib (BVD-523) and Hydroxychloroquine in Patients W Advanced MAPK-Mutated Gastrointestinal Adenocarcinomas
CTID: NCT04145297
Phase: Phase 1    Status: Completed
Date: 2024-11-18
New Clinical End-points in Patients With Primary Sjögren's Syndrome
CTID: NCT05113004
Phase: Phase 2    Status: Recruiting
Date: 2024-11-01
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Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
CTID: NCT05041907
Phase: Phase 2    Status: Recruiting
Date: 2024-10-28


Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada)
CTID: NCT04421664
Phase: Phase 3    Status: Terminated
Date: 2024-10-15
Study of Paclitaxel Protein Bound + Gemcitabine + Cisplatin + Hydrochloroquine as Treatment in Untreated Pancreas Cancer
CTID: NCT04669197
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-10-15
The Effects of Hydroxychloroquine in Patients with Inflammatory Cardiomyopathy
CTID: NCT05961202
Phase: Phase 2/Phase 3    Status: Recruiting
Date: 2024-10-09
PaTcH Study: A Phase 2 Study of Trametinib and Hydroxychloroquine in Patients With Metastatic Refractory Pancreatic Cancer
CTID: NCT05518110
Phase: Phase 2    Status: Recruiting
Date: 2024-09-26
Hydroxychloroquine Post Exposure Prophylaxis for Coronavirus Disease (COVID-19)
CTID: NCT04318444
Phase: Phase 2/Phase 3    Status: Terminated
Date: 2024-09-25
A Study of Hydroxychloroquine, Vitamin C, Vitamin D, and Zinc for the Prevention of COVID-19 Infection
CTID: NCT04335084
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-09-24
Akt Inhibitor MK2206 and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors, Melanoma, Prostate or Kidney Cancer
CTID: NCT01480154
Phase: Phase 1    Status: Active, not recruiting
Date: 2024-09-19
Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response
CTID: NCT03414502
Phase: Phase 3    Status: Recruiting
Date: 2024-09-19
Trial of Treatments for COVID-19 in Hospitalized Adults
CTID: NCT04315948
Phase: Phase 3    Status: Completed
Date: 2024-09-19
Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma
CTID: NCT04527549
Phase: Phase 2    Status: Terminated
Date: 2024-08-22
Hydroxychloroquine and Cognitive Function After Surgery
CTID: NCT03025087
Phase: Phase 4    Status: Terminated
Date: 2024-08-20
Gemcitabine, Docetaxel, and Hydroxychloroquine in Treating Participants With Recurrent or Refractory Osteosarcoma
CTID: NCT03598595
Phase: Phase 1/Phase 2    Status: Active, not recruiting
Date: 2024-08-19
Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer
CTID: NCT03037437
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-08-13
Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies
CTID: NCT05221320
Phase: Phase 2    Status: Terminated
Date: 2024-07-22
a Retrospective Study on the Systemic Treatment of LPP and FFA
CTID: NCT06512766
Phase:    Status: Completed
Date: 2024-07-22
The Effectiveness of Hydroxychloroquine Versus Methotrexate in the Treatment of Lichen Planopilaris in Routine Clinical Care: a Patient Preference Trial
CTID: NCT06512753
Phase:    Status: Recruiting
Date: 2024-07-22
Hydroxychloroquine in ANCA Vasculitis Evaluation
CTID: NCT04316494
Phase: Phase 4    Status: Active, not recruiting
Date: 2024-07-19
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
CTID: NCT02735707
Phase: Phase 3    Status: Recruiting
Date: 2024-07-12
IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA
CTID: NCT02451748
Phase: Phase 4    Status: Completed
Date: 2024-07-10
Hydroxychloroquine in Children's Interstitial Lung Diseases With Genetic Causes
CTID: NCT04532346
PhaseEarly Phase 1    Status: Not yet recruiting
Date: 2024-07-09
Management of Cardiovascular Disease in Kidney Disease (MaCK) Study
CTID: NCT03636152
Phase: Phase 2    Status: Completed
Date: 2024-07-03
The Efficacy and Safety of HCQ Plus Pred in ANA Positive ITP
CTID: NCT06479304
Phase: N/A    Status: Recruiting
Date: 2024-06-28
The Efficacy and Safety of HCQ Plus DEX in ANA Positive ITP
CTID: NCT06479317
Phase: N/A    Status: Recruiting
Date: 2024-06-28
The Efficacy and Safety of HCQ Plus TPO-RA in ANA Positive ITP
CTID: NCT06479291
Phase: N/A    Status: Recruiting
Date: 2024-06-28
Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease
CTID: NCT05799378
Phase: Phase 3    Status: Recruiting
Date: 2024-06-28
Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss
CTID: NCT06467526
Phase: Phase 2    Status: Not yet recruiting
Date: 2024-06-21
Efficacy and Safety of Baricitinib in Sjogren's Syndrome
CTID: NCT05016297
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-05-29
Hydroxychloroquine in Type 2 Diabetes During Pregnancy
CTID: NCT06319560
Phase: N/A    Status: Recruiting
Date: 2024-05-29
Pretreatment With HCQ Before Radiotherapy and Chemotherapy in Advanced NPC Patients
CTID: NCT06389201
Phase: N/A    Status: Not yet recruiting
Date: 2024-04-29
Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer
CTID: NCT03825289
Phase: Phase 1    Status: Recruiting
Date: 2024-04-19
Hydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Positive, HER2 Negative Breast Cancer
CTID: NCT03774472
Phase: Phase 1/Phase 2    Status: Completed
Date: 2024-04-19
Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus
CTID: NCT03428945
Phase: Phase 2    Status: Terminated
Date: 2024-04-09
A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration
CTID: NCT04201457
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-04-05
HCQ+ADC vs ADC in the Treatment of Advanced Breast Cancer
CTID: NCT06328387
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-03-25
ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer
CTID: NCT04523857
Phase: Phase 2    Status: Recruiting
Date: 2024-03-12
Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer
CTID: NCT04841148
Phase: Phase 2    Status: Recruiting
Date: 2024-03-12
CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine, EVErolimus or the Combination for Prevention of Recurrent Breast Cancer
CTID: NCT03032406
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-03-12
Evaluation of Hydroxychloroquine to Prevent CIPN
CTID: NCT05689359
Phase: Phase 2    Status: Withdrawn
Date: 2024-03-08
Hydroxychloroquine as a Steroid-sparing Agent in Extrapulmonary Sarcoidosis
CTID: NCT05841758
Phase: Phase 4    Status: Not yet recruiting
Date: 2024-03-06
Administration of Hydroxychloroquine (Plaquenil) to African Americans and Hispanics for the Treatment of Mild to Severe Ulcerative Colitis
CTID: NCT05119140
Phase: Phase 1/Phase 2    Status: Active, not recruiting
Date: 2024-03-04
A Study of Quintuple Therapy to Treat COVID-19 Infection
CTID: NCT04334512
Phase: Phase 2    Status: Completed
Date: 2024-02-29
Study of Combination Therapy With the MEK Inhibitor, Cobimetinib, Immune Checkpoint Blockade, Atezolizumab, and the AUTOphagy Inhibitor, Hydroxychloroquine in KRAS-mutated Advanced Malignancies
CTID: NCT04214418
Phase: Phase 1/Phase 2    Status: Active, not recruiting
Date: 2024-02-28
Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma
CTID: NCT05842174
Phase: Phase 1/Phase 2    Status: Not yet recruiting
Date: 2024-02-13
Study of Hydroxychloroquine With FOLFIRI and Bevacizumab in DTP-high Metastatic Colorectal Cancer
CTID: NCT05843188
Phase: Phase 2    Status: Recruiting
Date: 2024-02-09
Immune-Mediated Pathophysiology And Clinical Triage Program
CTID: NCT04354649
Phase: Phase 2    Status: Recruiting
Date: 2024-01-31
Multi-omics Studies on the Efficacy of Telitacicept in Chinese SLE Patients
CTID: NCT05666336
Phase: Phase 4    Status: Recruiting
Date: 2024-01-17
Hydroxychloroquine in Mild Graves' Orbitopathy
CTID: NCT05126147
Phase: Phase 4    Status: Recruiting
Date: 2024-01-17
Paricalcitol and Hydroxychloroquine in Combination With Gemcitabine and Nab-Paclitaxel for Advanced Pancreatic Cancer
CTID: NCT04524702
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-01-11
Vorinostat Plus Hydroxychloroquine Versus Regorafenib in Colorectal Cancer
CTID: NCT02316340
Phase: Phase 2    Status: Completed
Date: 2024-01-05
Randomised Evaluation of COVID-19 Therapy
CTID: NCT04381936
Phase: Phase 3    Status: Recruiting
Date: 2024-01-05
Study of Anti-Malarials in Incomplete Lupus Erythematosus
CTID: NCT03030118
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-01-03
Metabolic Effects of Hydroxychloroquine
CTID: NCT02026232
Phase: N/A    Status: Terminated
Date: 2023-12-28
Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis
CTID: NCT02603146
Phase: Phase 2    Status: Terminated
Date: 2023-12-20
Hydroxychloroquine in Prevention of Preeclampsia
CTID: NCT04755322
Phase: N/A    Status: Completed
Date: 2023-12-08
Hydroxychloroquine and Unexplained Recurrent Miscarriage
CTID: NCT04228263
Phase: N/A    Status: Completed
Date: 2023-12-07
The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia
CTID: NCT05287321
Phase: Phase 3    Status: Recruiting
Date: 2023-11-28
Safety and Effect on Pain and Function According to RAPID-3 of IHL-675A in Patients With Rheumatoid Arthritis
CTID: NCT05942911
Phase: Phase 2    Status: Recruiting
Date: 2023-11-27
Phase I/II Study of Hydroxychloroquine With Itraconazole With Biochemically Recurrent Prostate Cancer
CTID: NCT03513211
Phase: Phase 1/Phase 2    Status: Completed
Date: 2023-11-22
The Clinical Features and Pregnancy Outcomes of CTD Patients
CTID: NCT04918524
Phase:    Status: Recruiting
Date: 2023-11-18
The Clinical Efficacy and Safety of Iguratimod in RA and Early RA Patients for 6 Months Treatment
CTID: NCT03855007
Phase: Phase 4    Status: Completed
Date: 2023-11-18
To Determine the Safety of Regorafenib, Hydroxychloroquine, and Entinostat Metastatic Colorectal Cancer
CTID: NCT03215264
Phase: Phase 1    Status: Completed
Date: 2023-11-09
Hydroxychloroquine for Prevention of Recurrent Miscarriage.
CTID: NCT03165136
Phase: Phase 3    Status: Active, not recruiting
Date: 2023-10-02
Non-comparative Trial of the Combination of HCQ and AZI in the Treatment of ICU Patients
CTID: NCT04458948
Phase: Phase 2    Status: Terminated
Date: 2023-09-13
Hydroxychloroquine May be Beneficial for Preeclampsia
CTID: NCT06020378
Phase:    Status: Not yet recruiting
Date: 2023-08-31
Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).
CTID: NCT04566133
Phase: Phase 2    Status: Terminated
Date: 2023-08-21
Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer
CTID: NCT00786682
Phase: Phase 2    Status: Terminated
Date: 2023-08-14
Ixabepilone and Hydroxychloroquine in Treating Patients With Metastatic Breast Cancer
CTID: NCT00765765
Phase: Phase 1/Phase 2    Status: Terminated
Date: 2023-08-09
Sunitinib Malate and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy
CTID: NCT00813423
Phase: Phase 1    Status: Completed
Date: 2023-08-02
A Study of Nipocalimab With Co-administration of Etanercept or Hydroxychloroquine in Healthy Participants
CTID: NCT04973566
Phase: Phase 1    Status: Completed
Date: 2023-07-03
Efficacy of VHM After Treatment Interruption in Subjects Initiating ART During Acute HIV Infection
CTID: NCT02475915
Phase: Phase 1/Phase 2    Status: Completed
Date: 2023-06-22
To Evaluate Maximally Tolerated Dose (MTD), Safety and Efficacy of CPI-613® (Devimistat) Plus Hydroxychloroquine in Patients With Relapsed or Refractory Clear Cell Sarcoma of Soft Tissue
CTID: NCT04593758
Phase: Phase 1/Phase 2    Status: Completed
Date: 2023-05-24
Treatment of Muscle Cramps in Patients With Liver Cirrhosis
CTID: NCT01495403
PhaseEarly Phase 1    Status: Completed
Date: 2023-05-03
Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic
CTID: NCT04331834
Phase: Phase 3    Status: Completed
Date: 2023-05-01
CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors
CTID: NCT05733000
Phase: Phase 2    Status: Recruiting
Date: 2023-03-10
Using Hydroxychloroquine to Treat Nonalcoholic Steatohepatitis
CTID: NCT05733897
Phase:    Status: Recruiting
Date: 2023-03-02
Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers
CTID: NCT04328285
Phase: Phase 3    Status: Terminated
Date: 2023-03-01
High-dose Hydroxychloroquine for the Treatment of Ambulatory Patients With Mild COVID-19
CTID: NCT04351620
Phase: Phase 1    Status: Completed
Date: 2023-02-23
Hydroxychloroquine in Colchicine-Resistant Glucocorticoid-Dependent Idiopathic Recurrent Pericarditis
CTID: NCT05737680
Phase: Phase 3    Status: Not yet recruiting
Date: 2023-02-22
Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda
CTID: NCT01573754
Phase: Phase 2    Status: Completed
Date: 2023-02-17
University of Utah COVID-19 Hydrochloroquine Trial
CTID: NCT04342169
Phase: Phase 2    Status: Completed
Date: 2023-02-15
Hydroxychloroquine + Vorinostat in Advanced Solid Tumors
CTID: NCT01023737
Phase: Phase 1    Status: Completed
Date: 2023-02-13
Tacrolimus for Thrombocytopenia in SS
CTID: NCT05678335
Phase: Phase 2/Phase 3    Status: Unknown status
Date: 2023-01-10
Hydroxychloroquine, Abemaciclib and Endocrine Therapy in Hormone Receptor Positive (HR+)/Her 2 Negative Breast Cancer
CTID: NCT04316169
Phase: Phase 1    Status: Withdrawn
Date: 2022-12-23
The Clinical Features and Pregnancy Outcomes of RA Patients
CTID: NCT05651373
Phase:    Status: Recruiting
Date: 2022-12-15
COVID-19 PrEP HCW HCQ Study
CTID: NCT04354870
Phase: Phase 2    Status: Completed
Date: 2022-12-14
Telitacicept Followed With Rituximab Therapy on APS Secondary to SLE
CTID: NCT05644210
Phase:    Status: Recruiting
Date: 2022-12-09
The Clinical Efficacy of Immunomodulators in RA Patients
CTID: NCT05626348
Phase: Phase 4    Status: Recruiting
Date: 2022-11-29
Modulation of Autophagy in Patients With Advanced/Recurrent Non-small Cell Lung Cancer - Phase II
CTID: NCT01649947
Phase: Phase 2    Status: Completed
Date: 2022-11-21
Treatments Against RA and Effect on FDG-PET/CT
CTID: NCT02374021
Phase: Phase 4    Status: Completed
Date: 2022-10-26
Hydroxychloroquine Versus Pioglitazone in Combination Treatment for Type 2 Diabetes Mellitus
CTID: NCT02303405
Phase: Phase 2    Status: Terminated
Date: 2022-10-20
Prediction of Relapse Risk in Stable Systemic Lupus Erythematosus
CTID: NCT02842814
Phase: N/A    Status: Completed
Date: 2022-10-03
Hydroxychloroquine in Patients With Stage III or Stage IV Melanoma That Can Be Removed by Surgery
CTID: NCT00962845
PhaseEarly Phase 1    Status: Completed
Date: 2022-09-07
Efficacy and Safety of Mucoadhesive Sustained Release, Mucodentol, in Comparison With Hydroxychloroquine to Prevent COVID-19
CTID: NCT04466280
Phase: N/A    Status: Withdrawn
Date: 2022-08-03
Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + Sulfasalazine + Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate or Leflunomide
CTID: NCT02714634
Phase: Phase 4    Status: Recruiting
Date: 2022-07-12
Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on the Survival of Hospitalized Elderly Patients With COVID-19
CTID: NCT04359953
Phase: Phase 3    Status: Terminated
Date: 2022-07-11
Hydroxychloroquine in Treating Patients With Rising PSA Levels After Local Therapy for Prostate Cancer
CTID: NCT00726596
Phase: Phase 2    Status: Completed
Date: 2022-06-16
A Triple Combination Antiviral Coronavirus Therapy (TriACT) for COVID-19
CTID: NCT04605588
Phase: Phase 2    Status: Terminated
Date: 2022-05-05
Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis
CTID: NCT03449758
Phase: Phase 4    Status: Completed
Date: 2022-04-28
Treating COVID-19 With Hydroxychloroquine (TEACH)
CTID: NCT04369742
Phase: Phase 2    Status: Terminated
Date: 2022-04-22
Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19
CTID: NCT04329832
Phase: Phase 2    Status: Completed
Date: 2022-04-20
HC
Leflunomide and Hydroxychloroquine combination therapy
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2021-06-10
Hydroxychloroquine in isolated cutaneous mastocytosis patients or indolent systemic mastocytosis with associated skin involvement patients: proof of concept study
CTID: null
Phase: Phase 2    Status: Trial now transitioned
Date: 2020-11-09
An international randomised trial of additional treatments for COVID-19 in hospitalised patients who are all receiving the local standard of care
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-06-22
Pragmatic study 'CORIVER': Ivermectin as antiviral treatment for patients infected by SARS-COV2 (COVID-19)
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-06-02
Effectiveness of the combined treatment with hydroxycloroquine and azithromycin vs lopinavir/ritonavir + hydroxycloroquine in hospitalized patients with confirmed COVID-19 infection
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2020-05-29
Prevention of COVID19 infection with hydroxychloroquine in institutionalized older people and nursing home staff. An open, randomized controlled stepped-wedge clinical trial by clusters.
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-05-22
Controlled and randomised trial to assess the safety and efficacy of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in hospital healthcare personnel (Sanitarios sin COVID-19 -SANsinCOVID-19).
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2020-05-15
TOFAcitinib plus Hydroxycloroquine vs Hydroxycloroquine in patients with early onset SARS-CoV2 (COVID-19) interstitial pneumonia: a multicenter randomized controlled open label trial
CTID: null
Phase: Phase 2    Status: Completed
Date: 2020-05-15
Adaptive Randomized trial for therapy of COrona virus disease 2019 at home with oral antivirals
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-05-14
Randomized, Controlled, Double-blind Clinical Trial Comparing the Efficacy
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2020-05-13
PRECOV: a randomized controlled clinical trial on the effects of hydroxychloroquine in the prevention of COVID-19 in healthcare workers at risk
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-05-06
A multicentre, prospective, randomised trial comparing standard of care (SOC) alone, SOC plus hydroxychloroquine monotherapy or SOC plus a combination of hydroxychloroquine and azithromycin in the treatment of non-critical, SARS-CoV-2 PCR-positive population not requiring immediate resuscitation or ventilation but who have evidence of clinical decline.
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2020-05-05
EARLY TREATMENT OF PNEUMONIA COVID-19 WITH GLUCOCORTICOIDS.
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-04-30
A Randomised Controlled Trial of Early Intervention in Patients HospItalised with COVID-19: Favipiravir verses HydroxycholorquiNe & Azithromycin & Zinc vErsEs Standard CaRe
CTID: null
Phase: Phase 3    Status: GB - no longer in EU/EEA
Date: 2020-04-29
CLINICAL TRIAL OF THE USE OF ANAKINRA (ANTI IL-1) IN CYTOKINE STORM SYNDROME (CSS) SECONDARY TO COVID-19
CTID: null
Phase: Phase 2, Phase 3    Status: Ongoing
Date: 2020-04-28
PROTECT: A randomized study with Hydroxychloroquine versus observational support for prevention or early phase treatment of Coronavirus disease (COVID-19).
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2020-04-28
Cumulative adaptive, multiarm, multistage and multicentre randomized clinical trial with immunotherapy for Moderate COVID-19
CTID: null
Phase: Phase 2, Phase 3    Status: Prematurely Ended
Date: 2020-04-27
PRE-EXPOSURE PROPHYLAXIS WITH HYDROXYCHLOROQUINE IN SANITARIES HIGHLY EXPOSED TO COVID-19. (COVIDNA)
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-04-23
COVID-19 Prophylaxis with hydroxychloroquine, Vitamin D, and Zinc supplementation in Danish nursing home residents – a randomized controlled trial
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-23
Phase I/II clinical trial to evaluate the safety and efficacy of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cells Expanded in patients with severe COVID-19 pneumonia
CTID: null
Phase: Phase 1, Phase 2    Status: Ongoing
Date: 2020-04-20
Pilot, double-blind clinical trial to evaluate the efficacy and safety of pre-exposure use of hydroxychloroquine versus placebo in the prevention of SARS-CoV-2 (COVID-19) infection in healthcare personnel.
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-19
Prophylaxis of COVID-19 infection with hydroxychloroquine in healthcare
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-18
The Danish Pre-HCQ Dialysis Study:
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-15
Efficacy and safety of novel treatment options for adults with COVID-19 pneumonia. A double-blinded, randomized, multi-stage, 6-armed placebo-controlled trial in the framework of an adaptive trial platform
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-14
ChemoPROphyLaxIs For covId-19 infeCtious disease (the PROLIFIC trial)
CTID: null
Phase: Phase 3    Status: GB - no longer in EU/EEA
Date: 2020-04-14
An open label single center randomized controlled trial to evaluate the effect of hydroxychloroquine on viral shedding in mild COVID-19
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2020-04-12
Efficacy and safety of sarilumab in the early treament of hospitalized patients with mild-moderate neumonia and COVID19 infection versus standard of care
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-11
Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on Survival in Elderly Hospitalized Patients with VIDOC-19 : A Randomized, Multi-Centre, Adaptive, Blinded Study
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-11
Pragmatic clinical trial to evaluate the efficacy of hydroxychloroquine in the treatment of COVID-19 infection in two cohorts: patients with oncohaematological disease and SARS-CoV-2 positive without radiological alteration and sars-cov-2 positive professionals without radiological alteration
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2020-04-11
Prospective, phase II, randomized, open-label, parallel group study to evaluate the efficacy of hydroxychloroquine together with baricitinib, imatinib or early lopinavir / ritonavir in patients with SARS Cov2 pneumonia (COVID-19 HUF)
CTID: null
Phase: Phase 2    Status: Completed
Date: 2020-04-11
COVID-19+
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-10
Hydroxychloroquine sulfate early administration in symptomatic out of hospital COVID-19 positive patients. Hydro-Stop-COVID19 Trial
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-04-09
Dexamethasone associated with hydroxychloroquine vs. hydroxychloroquine alone for the early treatment of severe ARDS caused by COVID-19 : a randomized controlled trial
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-09
Hydroxychloroquine efficacy in preventing SARS-CoV-2 infection and CoVid-19 disease severity during pregnancy
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2020-04-08
Randomized open label trial assessing efficacy and safety of hydroxychloroquine plus azithromycin versus hydroxychloroquine for hospitalized patients with COVID-19
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-07
Randomized clinical trial to evaluate the efficacy of hydroxychloroquine associated or not with azithromycin as a treatment for COVID-19 infection.
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2020-04-07
Chemoprophylaxis of SARS-CoV-2 infection (COVID-19) in exposed healthcare workers: a randomized double-blind placebo-controlled clinical trial
CTID: null
Phase: Phase 3    Status: Completed
Date: 2020-04-07
PRE-EXPOSURE PROPHYLAXIS WITH HYDROXYCHLOROQUINE FOR HIGH-RISK HEALTHCARE WORKERS DURING THE COVID-19 PANDEMIC (PrEP_COVID): A UNICENTRIC, DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL.
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2020-04-03
COVID-19 - Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease upon Hydroxychloroquine and Azithromycin Therapy in French Cancer patients
CTID: null
Phase: Phase 2    Status: Completed
Date: 2020-04-03
Proactive Prophylaxis with Azithromycin and Hydroxychloroquine Patients Hospitalized with COVID
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2020-04-03
Monocentric Population Pharmacokinetic study of Hydroxychloroquine in COVID-19 Patients to inform its dosing optimization.
CTID: null
Phase: Phase 4    Status: Completed
Date: 2020-03-31
Evaluation of the concentration/viral effect relationship of hydroxychloroquine in COVID-19 patients in the intensive care unit.
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2020-03-30
Prevention of SARS-CoV-2 (COVID-19) through Pre-Exposure Prophylaxis with Tenof e.querySelector("font strong").innerText = 'View More' } else if(up_display === 'none' || up_display === '') { icon_angle_down.style.displa

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