| 规格 | 价格 | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| 体内研究 (In Vivo) |
BG136（0.3 mg/kg，静脉注射，每周两次）能够抑制 C57BL/6 J 小鼠结直肠癌 (CRC) 细胞系 MC38 同种异体肿瘤模型中的体内肿瘤生长，且未观察到体重减轻[1]。在 MC38 同种异体肿瘤模型中，BG136（0.3 mg/kg，静脉注射，每周两次）与抗 PD1 抗体（200 μg/只小鼠，静脉注射，每周一次）联合使用可增强抗 PD1 抗体的肿瘤抑制效果，更有效地抑制肿瘤生长[1]。
|
|---|---|
| 动物实验 |
Animal/Disease Models: MC38 syngeneic tumor C57BL/6 J mice model[1].
Doses: 0.3 mg/kg Route of Administration: i.v. twice a week alone, or BG136 in combination with PD1 antibody (200 μg per mouse, i.v. once a week) Experimental Results: Significantly increased the infiltration of total CD45+ immune cells and CD8+ T cells in the tumor microenvironment (TME), as well as the proportion of cells expressing tumor necrosis factor α (TNFα) and granzyme B. Significantly upregulated the antigen-presenting related genes CD74, H2-Ab1, and CD8b1, as well as the pro-inflammatory cytokine IFNγ. Led to a significant decrease in Ki67 expression, indicating the inhibition of cell proliferation in the tumor microenvironment (TME), when used in combination with anti-PD1 antibody. Was able to induce the gene expression of the pro-inflammatory cytokines IFNγ and TNFα, as well as the expression of the antitumor M1-like macrophage marker gene iNOS, and inhibit the expression of the tumor-promoting M2-like macrophage marker Arginase 1, when used in combination with anti-PD1 antibody. |
| 参考文献 |
| 分子量 |
4000-7000
|
|---|---|
| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
计算结果:
工作液浓度： mg/mL；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度，请首先与我们联系。
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
(1) 请确保溶液澄清之后，再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶；
(2) 一定要按顺序加入溶剂 (助溶剂) 。
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