14-hydroxy Clarithromycin

别名: (14R)-14羟基克拉霉素;(14R)-14-羟基克拉霉素
目录号: V41308 纯度: ≥98%
14-羟基克拉霉素是克拉霉素的杂质
14-hydroxy Clarithromycin CAS号: 116836-41-0
产品类别: New1
产品仅用于科学研究,不针对患者销售
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500mg
1g
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产品描述
14-羟基克拉霉素是克拉霉素的杂质
生物活性&实验参考方法
药代性质 (ADME/PK)
吸收、分布和排泄
克拉霉素吸收良好,耐酸,可与食物同服。
每12小时服用250毫克片剂后,约20%的剂量以克拉霉素的形式经尿液排出;而每12小时服用500毫克片剂后,克拉霉素的尿排泄量略高,约为30%。
关于克拉霉素在人体内的分布数据有限。克拉霉素和14-羟基克拉霉素似乎分布于大多数身体组织和体液中。由于药物在细胞内浓度较高,组织浓度高于血清浓度。在接受手术的患者组织样本中检测到了高浓度的克拉霉素。据报道,术前3天每12小时口服250-500毫克克拉霉素的患者,在给药后4小时达到肺、扁桃体和鼻黏膜中的克拉霉素峰浓度,平均浓度分别为13.5-17.5、5.3-6.5和5.9-8.3毫克/公斤;然而,有研究表明,由于微生物检测无法区分母体药物及其活性代谢物,这些数据可能高估了克拉霉素的组织浓度。在接受克拉霉素混悬液治疗中耳炎的儿童中,剂量为7.5毫克/公斤,每12小时一次,共5次,中耳积液中克拉霉素和14-羟基克拉霉素的峰浓度分别为2.5和1.3微克/毫升。伴随血清浓度分别为 1.7 和 0.8 μg/mL。动物研究结果表明,给予放射性标记的克拉霉素或红霉素后,克拉霉素在各种身体组织(尤其是肺)中具有更高且更持久的活性。
口服克拉霉素后,其在胃肠道中的吸收迅速;其胃肠道吸收率高于红霉素。
克拉霉素通过肾脏和非肾脏途径清除。
健康男性单次口服 250 mg 放射性标记的克拉霉素后,5 天内约有 38% 的剂量(其中 18% 为克拉霉素)经尿液排出,40% 的剂量(其中 4% 为克拉霉素)经粪便排出。口服克拉霉素片剂,每12小时服用250或500毫克,约有20%或30%的剂量在12小时内以原形经尿液排出。口服克拉霉素混悬液,每12小时服用250毫克,约有40%的给药剂量以原形经尿液排出。克拉霉素的主要代谢产物是14-羟基克拉霉素,服用250或500毫克克拉霉素片剂后,尿液中约占剂量的10-15%。
有关克拉霉素(共6种)的更多吸收、分布和排泄(完整)数据,请访问HSDB记录页面。
代谢/代谢产物
肝脏代谢 - 主要由CYP3A4代谢,导致多种药物相互作用。
克拉霉素的主要代谢产物是14-羟基克拉霉素,服用250或500毫克克拉霉素片剂后,尿液中约占剂量的10-15%。
克拉霉素在肝脏中广泛代谢,主要通过氧化N-去甲基化和14位羟基化进行代谢;克拉霉素的糖基部分在胃中也会发生少量水解裂解。虽然已鉴定出至少7种克拉霉素代谢物,但14-羟基克拉霉素是血清中的主要代谢物,也是唯一具有显著抗菌活性的代谢物。14-羟基克拉霉素的R-和S-差向异构体均可在体内生成,但R-差向异构体的含量更高,抗菌活性也更强。克拉霉素的代谢似乎是饱和的,因为服用 800 毫克母体药物后产生的 14-羟基克拉霉素的量仅比服用 250 毫克母体药物后产生的量略高。
健康男性口服单剂量 250 毫克放射性标记的克拉霉素后,5 天内约有 38% 的剂量(18% 为克拉霉素)经尿液排出,40% 的剂量(4% 为克拉霉素)经粪便排出。尿液中发现的主要代谢物是14-羟基克拉霉素,约占服用250或500毫克克拉霉素片剂后剂量的10-15%。
生物半衰期
3-4小时
健康男性单次口服250毫克或1.2克克拉霉素常规片剂后,其消除半衰期平均分别为4小时或11小时。据报道,每12小时多次给药时,克拉霉素的消除半衰期从每12小时服用250毫克(常规片剂)后的3-4小时增加到每8-12小时服用500毫克后的5-7小时; 14-羟基克拉霉素的半衰期从250毫克剂量时的5-6小时增加到500毫克剂量时的7-9小时。当克拉霉素以口服混悬液形式给药时,药物及其14-羟基代谢物的消除半衰期似乎与服用等剂量克拉霉素片剂后达到稳态时观察到的半衰期相似。
毒性/毒理 (Toxicokinetics/TK)
药物相互作用
达非那新生产商指出,对于同时服用强效CYP3A4抑制剂(包括克拉霉素)的患者,达非那新每日剂量不应超过7.5 mg。
克拉霉素与西沙必利合用是禁忌的。克拉霉素和/或红霉素与西沙必利合用与QT间期延长和严重心律失常(室性心动过速、室颤、尖端扭转型室性心动过速)相关;已有死亡病例报告。在2例接受西沙必利(10 mg,每日3-4次)治疗的慢性肾功能衰竭患者中,开始服用克拉霉素(500 mg,每日2次)后数日内出现QT间期延长和/或尖端扭转型室性心动过速。一名患者出现血清西沙必利浓度升高,停用克拉霉素后,西沙必利浓度下降。
服用卡马西平的患者应谨慎使用克拉霉素;如果同时服用克拉霉素和卡马西平,建议减少卡马西平的剂量和/或监测血浆卡马西平浓度。有限的健康男性数据表明,克拉霉素可能会增加卡马西平的血清浓度-时间曲线下面积(AUC),并降低卡马西平 10,11-环氧化物(CBZ-E)的血清峰浓度和 AUC。2 51 此外,在一些接受卡马西平(600 mg/天)治疗的患者中,无论是否联合其他药物,在开始克拉霉素治疗(200 mg,每日两次)后 3-5 天内,卡马西平(而非 CBZ-E)的血浆浓度升高,并且在某些患者中出现了卡马西平中毒的表现(即嗜睡、头晕、共济失调)。停用卡马西平后,血浆卡马西平浓度降低,毒性症状在几天内消退。
艾司佐匹克隆的生产商指出,如果艾司佐匹克隆与强效CYP3A4抑制剂(包括克拉霉素)同时使用,则应减少艾司佐匹克隆的剂量。在这种情况下,艾司佐匹克隆的初始剂量不应超过 1 mg,但如果临床需要,可增加至 2 mg。457
有关克拉霉素(共 36 项)的更多相互作用(完整)数据,请访问 HSDB 记录页面。
非人类毒性值
大鼠皮下注射 LD50 >5 g/kg
大鼠腹腔注射 LD50 669 mg/kg
大鼠口服 LD50 1270 mg/kg
小鼠静脉注射 LD50 173 mg/kg
有关克拉霉素(共 7 项)的更多非人类毒性值(完整)数据,请访问 HSDB 记录页面。
其他信息
治疗用途
抗菌药物
口服克拉霉素常与阿莫西林和兰索拉唑或奥美拉唑(三联疗法)联合用于治疗幽门螺杆菌感染和十二指肠溃疡。克拉霉素也可与奥美拉唑(二联疗法)或枸橼酸铋雷尼替丁联合用于治疗伴有活动性十二指肠溃疡的幽门螺杆菌感染患者。此外,克拉霉素还曾与其他药物联合治疗方案(可联合或不联合阿莫西林、兰索拉唑、奥美拉唑或枸橼酸铋雷尼替丁)用于治疗与消化性溃疡相关的幽门螺杆菌感染。 /美国产品标签包含/
克拉霉素口服用于治疗咽炎和扁桃体炎、轻度至中度呼吸道感染(慢性支气管炎急性细菌性加重、急性上颌窦炎、社区获得性肺炎)、非复杂性皮肤及皮肤软组织感染以及由敏感菌引起的急性中耳炎。克拉霉素还口服用于治疗晚期人类免疫缺陷病毒(HIV)感染患者由鸟分枝杆菌复合群(MAC)引起的播散性感染,以及预防HIV感染者发生播散性MAC感染(一级预防和二级预防)。 /美国产品标签包含/
克拉霉素(常规片剂)与阿莫西林和兰索拉唑或奥美拉唑(三联疗法)联合使用,用于治疗幽门螺杆菌(以前称为幽门弯曲杆菌或幽门螺杆菌)感染引起的十二指肠溃疡(活动性或病史不超过1年)患者。克拉霉素也可与奥美拉唑(二联疗法)或枸橼酸铋雷尼替丁联合使用,用于治疗活动性十二指肠溃疡患者的幽门螺杆菌感染。 /包含于美国产品标签/
有关克拉霉素(共17种)的更多治疗用途(完整)数据,请访问HSDB记录页面。
药物警告
已报告38例克拉霉素引起的神经毒性病例。患者平均年龄为51.3岁(范围:19-87岁),其中女性占52.6%。精神疾病是最常见的合并症,仅有2例患者患有肾功能衰竭。大多数患者服用克拉霉素是为了治疗呼吸道感染,仅有2例患者每日服用超过1000毫克的抗生素。症状在开始服用克拉霉素后1至10天内出现(平均5天)。71%的患者同时服用其他药物,其中8例患者正在接受精神活性药物治疗。停用克拉霉素后,患者预后良好,但58%的患者在急性期需要使用抗精神病药物或苯二氮卓类药物。仅有4例患者接受了脑电图(EEG)检查。我们病例中的典型患者是一位74岁女性,因克拉霉素诱发非惊厥性癫痫持续状态(NCSE)而出现谵妄。停用克拉霉素后,她的临床症状和脑电图(EEG)结果均显著改善。中枢神经系统副作用的潜在机制尚不明确。我们建议将脑电图检查纳入克拉霉素治疗期间出现神经毒性症状患者的诊断流程,因为脑电图有助于区分精神疾病患者与脑病或癫痫患者。由于克拉霉素的广泛应用,临床医生应充分了解其神经毒性。早期发现克拉霉素引起的神经毒性并停药可能使患者完全康复。
研究人员使用克拉霉素单药治疗13例患有慢性分枝杆菌肺病的老年患者,剂量为1000 mg,每日两次。患者平均年龄为70岁,13例患者中有12例肌酐清除率为31-71 ml/min。所有患者均出现不良反应,最常见的不良反应为苦味(92%)、恶心(92%)、呕吐(54%)和中枢神经系统症状(54%)。13例患者中有5例(38%)在治疗1-6周出现肝酶升高。克拉霉素及其14-OH代谢物的平均血清浓度为12.9 ± 3.6 μg/ml(标准差)。共有11例患者(85%)因副作用在3个月内停用高剂量药物。在6例停药患者中,6例(10/10)克拉霉素及其14-OH代谢物的血清药物浓度持续超过12微克/毫升;而2例耐受高剂量的患者中,均未达到此浓度(0/6)。将剂量减至500毫克,每日两次,耐受性良好(10例患者中有9例耐受)。未来在该人群中使用克拉霉素的试验应采用较低剂量,并注意体重和肾功能,以最大程度地减少副作用。
动物实验中,克拉霉素剂量达到最大推荐人剂量(按mg/m²计算)的8-12倍时,曾出现角膜混浊。
克拉霉素联合奥美拉唑治疗报告的其他不良反应与单独使用奥美拉唑的不良反应不同,包括鼻炎(2%的患者)、咽炎(1%的患者)和流感样症状(1%的患者)。
有关克拉霉素的更多药物警告(完整)数据(共22条),请访问HSDB记录页面。
药效学
克拉霉素是一种大环内酯类抗生素,其抗菌谱包括多种革兰氏阳性菌(金黄色葡萄球菌、肺炎链球菌和化脓性链球菌)和克拉霉素对革兰氏阴性需氧菌(如流感嗜血杆菌、副流感嗜血杆菌和卡他莫拉菌)、多种厌氧菌、部分分枝杆菌以及其他一些微生物(包括支原体、脲原体、衣原体、弓形虫和伯氏疏螺旋体)均有效。克拉霉素还对肺炎衣原体和肺炎支原体等需氧菌具有抗菌活性。体外实验表明,克拉霉素对红霉素敏感菌的抗菌活性与红霉素相当或更强。克拉霉素通常为抑菌剂,但根据微生物种类和药物浓度,也可能具有杀菌作用。
*注: 文献方法仅供参考, InvivoChem并未独立验证这些方法的准确性
化学信息 & 存储运输条件
分子式
C38H69NO13
分子量
747.95336
精确质量
747.477
CAS号
116836-41-0
PubChem CID
84029
外观&性状
Colorless needles from chloroform + diisopropyl ether (1:2) ... Also reported as crystals from ethanol
LogP
2.439
tPSA
182.91
氢键供体(HBD)数目
4
氢键受体(HBA)数目
14
可旋转键数目(RBC)
8
重原子数目
52
分子复杂度/Complexity
1190
定义原子立体中心数目
18
SMILES
O([C@H]1[C@@H]([C@H](C[C@@H](C)O1)N(C)C)O)[C@H]1[C@@](C)(C[C@@H](C)C([C@H](C)[C@H]([C@@](C)([C@@H](CC)OC([C@H](C)[C@H]([C@@H]1C)O[C@H]1C[C@](C)([C@H]([C@H](C)O1)O)OC)=O)O)O)=O)OC
InChi Key
AGOYDEPGAOXOCK-KCBOHYOISA-N
InChi Code
InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
化学名
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
HS Tariff Code
2934.99.9001
存储方式

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

运输条件
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
溶解度数据
溶解度 (体外实验)
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
溶解度 (体内实验)
注意: 如下所列的是一些常用的体内动物实验溶解配方,主要用于溶解难溶或不溶于水的产品(水溶度<1 mg/mL)。 建议您先取少量样品进行尝试,如该配方可行,再根据实验需求增加样品量。

注射用配方
(IP/IV/IM/SC等)
注射用配方1: DMSO : Tween 80: Saline = 10 : 5 : 85 (如: 100 μL DMSO 50 μL Tween 80 850 μL Saline)
*生理盐水/Saline的制备:将0.9g氯化钠/NaCl溶解在100 mL ddH ₂ O中,得到澄清溶液。
注射用配方 2: DMSO : PEG300Tween 80 : Saline = 10 : 40 : 5 : 45 (如: 100 μL DMSO 400 μL PEG300 50 μL Tween 80 450 μL Saline)
注射用配方 3: DMSO : Corn oil = 10 : 90 (如: 100 μL DMSO 900 μL Corn oil)
示例: 注射用配方 3 (DMSO : Corn oil = 10 : 90) 为例说明, 如果要配制 1 mL 2.5 mg/mL的工作液, 您可以取 100 μL 25 mg/mL 澄清的 DMSO 储备液,加到 900 μL Corn oil/玉米油中, 混合均匀。
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注射用配方 4: DMSO : 20% SBE-β-CD in Saline = 10 : 90 [如:100 μL DMSO 900 μL (20% SBE-β-CD in Saline)]
*20% SBE-β-CD in Saline的制备(4°C,储存1周):将2g SBE-β-CD (磺丁基-β-环糊精) 溶解于10mL生理盐水中,得到澄清溶液。
注射用配方 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (如: 500 μL 2-Hydroxypropyl-β-cyclodextrin (羟丙基环胡精) 500 μL Saline)
注射用配方 6: DMSO : PEG300 : Castor oil : Saline = 5 : 10 : 20 : 65 (如: 50 μL DMSO 100 μL PEG300 200 μL Castor oil 650 μL Saline)
注射用配方 7: Ethanol : Cremophor : Saline = 10: 10 : 80 (如: 100 μL Ethanol 100 μL Cremophor 800 μL Saline)
注射用配方 8: 溶解于Cremophor/Ethanol (50 : 50), 然后用生理盐水稀释。
注射用配方 9: EtOH : Corn oil = 10 : 90 (如: 100 μL EtOH 900 μL Corn oil)
注射用配方 10: EtOH : PEG300Tween 80 : Saline = 10 : 40 : 5 : 45 (如: 100 μL EtOH 400 μL PEG300 50 μL Tween 80 450 μL Saline)


口服配方
口服配方 1: 悬浮于0.5% CMC Na (羧甲基纤维素钠)
口服配方 2: 悬浮于0.5% Carboxymethyl cellulose (羧甲基纤维素)
示例: 口服配方 1 (悬浮于 0.5% CMC Na)为例说明, 如果要配制 100 mL 2.5 mg/mL 的工作液, 您可以先取0.5g CMC Na并将其溶解于100mL ddH2O中,得到0.5%CMC-Na澄清溶液;然后将250 mg待测化合物加到100 mL前述 0.5%CMC Na溶液中,得到悬浮液。
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口服配方 3: 溶解于 PEG400 (聚乙二醇400)
口服配方 4: 悬浮于0.2% Carboxymethyl cellulose (羧甲基纤维素)
口服配方 5: 溶解于0.25% Tween 80 and 0.5% Carboxymethyl cellulose (羧甲基纤维素)
口服配方 6: 做成粉末与食物混合


注意: 以上为较为常见方法,仅供参考, InvivoChem并未独立验证这些配方的准确性。具体溶剂的选择首先应参照文献已报道溶解方法、配方或剂型,对于某些尚未有文献报道溶解方法的化合物,需通过前期实验来确定(建议先取少量样品进行尝试),包括产品的溶解情况、梯度设置、动物的耐受性等。

请根据您的实验动物和给药方式选择适当的溶解配方/方案:
1、请先配制澄清的储备液(如:用DMSO配置50 或 100 mg/mL母液(储备液));
2、取适量母液,按从左到右的顺序依次添加助溶剂,澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明,并不一定代表此产品 的实际溶解配方):
10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline);
假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀/澄清;向上述体系中加入50 μL Tween-80,混合均匀/澄清;然后继续加入450 μL ddH2O (或 saline)定容至 1 mL;

3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例;
4、 如产品在配制过程中出现沉淀/析出,可通过加热(≤50℃)或超声的方式助溶;
5、为保证最佳实验结果,工作液请现配现用!
6、如不确定怎么将母液配置成体内动物实验的工作液,请查看说明书或联系我们;
7、 以上所有助溶剂都可在 Invivochem.cn网站购买。
制备储备液 1 mg 5 mg 10 mg
1 mM 1.3370 mL 6.6849 mL 13.3699 mL
5 mM 0.2674 mL 1.3370 mL 2.6740 mL
10 mM 0.1337 mL 0.6685 mL 1.3370 mL

1、根据实验需要选择合适的溶剂配制储备液 (母液):对于大多数产品,InvivoChem推荐用DMSO配置母液 (比如:5、10、20mM或者10、20、50 mg/mL浓度),个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;

2、如果您找不到您想要的溶解度信息,或者很难将产品溶解在溶液中,请联系我们;

3、建议使用下列计算器进行相关计算(摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等);

4、母液配好之后,将其分装到常规用量,并储存在-20°C或-80°C,尽量减少反复冻融循环。

计算器

摩尔浓度计算器可计算特定溶液所需的质量、体积/浓度,具体如下:

  • 计算制备已知体积和浓度的溶液所需的化合物的质量
  • 计算将已知质量的化合物溶解到所需浓度所需的溶液体积
  • 计算特定体积中已知质量的化合物产生的溶液的浓度
使用摩尔浓度计算器计算摩尔浓度的示例如下所示:
假如化合物的分子量为350.26 g/mol,在5mL DMSO中制备10mM储备液所需的化合物的质量是多少?
  • 在分子量(MW)框中输入350.26
  • 在“浓度”框中输入10,然后选择正确的单位(mM)
  • 在“体积”框中输入5,然后选择正确的单位(mL)
  • 单击“计算”按钮
  • 答案17.513 mg出现在“质量”框中。以类似的方式,您可以计算体积和浓度。

稀释计算器可计算如何稀释已知浓度的储备液。例如,可以输入C1、C2和V2来计算V1,具体如下:

制备25毫升25μM溶液需要多少体积的10 mM储备溶液?
使用方程式C1V1=C2V2,其中C1=10mM,C2=25μM,V2=25 ml,V1未知:
  • 在C1框中输入10,然后选择正确的单位(mM)
  • 在C2框中输入25,然后选择正确的单位(μM)
  • 在V2框中输入25,然后选择正确的单位(mL)
  • 单击“计算”按钮
  • 答案62.5μL(0.1 ml)出现在V1框中
g/mol

分子量计算器可计算化合物的分子量 (摩尔质量)和元素组成,具体如下:

注:化学分子式大小写敏感:C12H18N3O4  c12h18n3o4
计算化合物摩尔质量(分子量)的说明:
  • 要计算化合物的分子量 (摩尔质量),请输入化学/分子式,然后单击“计算”按钮。
分子质量、分子量、摩尔质量和摩尔量的定义:
  • 分子质量(或分子量)是一种物质的一个分子的质量,用统一的原子质量单位(u)表示。(1u等于碳-12中一个原子质量的1/12)
  • 摩尔质量(摩尔重量)是一摩尔物质的质量,以g/mol表示。
/

配液计算器可计算将特定质量的产品配成特定浓度所需的溶剂体积 (配液体积)

  • 输入试剂的质量、所需的配液浓度以及正确的单位
  • 单击“计算”按钮
  • 答案显示在体积框中
动物体内实验配方计算器(澄清溶液)
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶/难溶于水的化合物),不同的产品和批次配方组成不同,如对配方有疑问,可先联系我们提供正确的体内实验配方。此外,请注意这只是一个配方计算器,而不是特定产品的确切配方。
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+
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计算结果:

工作液浓度 mg/mL;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度,请首先与我们联系。

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

(1) 请确保溶液澄清之后,再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶;
            (2) 一定要按顺序加入溶剂 (助溶剂) 。

临床试验信息
A 'Screen and Treat' Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of Chile
CTID: NCT05926804
Phase: N/A    Status: Recruiting
Date: 2024-11-18
Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Participants With B-Cell Malignancies
CTID: NCT04551963
Phase: Phase 1    Status: Completed
Date: 2024-10-26
Drug-Drug Interactions Between TNP-2198 and Midazolam, Clarithromycin
CTID: NCT06551623
Phase: Phase 1    Status: Completed
Date: 2024-10-24
A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
CTID: NCT04630145
Phase: Phase 2/Phase 3    Status: Active, not recruiting
Date: 2024-10-24
Clarithromycin Treatment to Prevent Sepsis Progression in CAP (REACT)
CTID: NCT06294600
Phase: Phase 3    Status: Recruiting
Date: 2024-10-23
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Carfilzomib, Clarithromycin (Biaxin®), Lenalidomide (Revlimid®), and Dexamethasone (Decadron®) [Car-BiRD] Therapy for Subjects With Multiple Myeloma
CTID: NCT01559935
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-09-26


Ixazomib with Pomalidomide, Clarithromycin and Dexamethasone in Treating Patients with Multiple Myeloma
CTID: NCT02542657
Phase: Phase 1/Phase 2    Status: Active, not recruiting
Date: 2024-09-19
Selinexor and Backbone Treatments of Multiple Myeloma Patients
CTID: NCT02343042
Phase: Phase 1/Phase 2    Status: Recruiting
Date: 2024-09-19
Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.
CTID: NCT06603688
Phase: Phase 4    Status: Recruiting
Date: 2024-09-19
7 Days Vs. 14 Days of Vonoprazan-based Triple Therapy for H. Pylori Eradication
CTID: NCT06576882
Phase: Phase 3    Status: Active, not recruiting
Date: 2024-08-30
Vonoprazan for Helicobacter Pylori Eradication in Adolescents
CTID: NCT06162949
Phase: Phase 3    Status: Completed
Date: 2024-08-28
Clarithromycin 500 mg Tablets Under Non-Fasting Conditions
CTID: NCT00836706
Phase: Phase 1    Status: Completed
Date: 2024-08-20
Clarithromycin 500 mg Tablets Under Fasting Conditions
CTID: NCT00835692
Phase: Phase 1    Status: Completed
Date: 2024-08-20
The Potential of Givinostat as DDI Victim in Co-administration P-gp Inhibitor (Part 2)
CTID: NCT05845567
Phase: Phase 1    Status: Completed
Date: 2024-08-16
Standard or Short-course Vonoprazan Non-bismuth Triple Therapy or High-dose Dual Therapy Versus Rabeprazole-bismuth Quadruple Therapy for Primary Helicobacter Pylori Eradication
CTID: NCT06168214
Phase: Phase 4    Status: Recruiting
Date: 2024-08-13
Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment
CTID: NCT06523764
Phase: Phase 4    Status: Not yet recruiting
Date: 2024-07-30
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
CTID: NCT06396078
Phase: Phase 4    Status: Recruiting
Date: 2024-07-29
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication
CTID: NCT06514274
Phase: Phase 4    Status: Not yet recruiting
Date: 2024-07-23
Autologous Stem Cell Transplant With Pomalidomide (CC-4047®) Maintenance Versus Continuous Clarithromycin/ Pomalidomide / Dexamethasone Salvage Therapy in Relapsed or Refractory Multiple Myeloma
CTID: NCT01745588
Phase: Phase 2    Status: Active, not recruiting
Date: 2024-07-03
A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to Daratumumab
CTID: NCT04302324
Phase: Phase 2    Status: Recruiting
Date: 2024-06-26
Clarithromycin Mechanisms in Hypersomnia Syndromes
CTID: NCT04026958
Phase: Phase 2    Status: Recruiting
Date: 2024-06-20
Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori Infection
CTID: NCT06250634
Phase: N/A    Status: Completed
Date: 2024-05-29
Comparative Bioavailability Study of Clarithromycin 250 mg Tablets
CTID: NCT00648830
Phase: Phase 1    Status: Completed
Date: 2024-04-24
Efficacy and Safety of Rifasutenizol (TNP 2198) in Participants With H. Pylori Infection
CTID: NCT05857163
Phase: Phase 3    Status: Completed
Date: 2024-04-02
A Study to Determine the Effect of KP-001 on Metformin and Midazolam Pharmacokinetics and the Effect of Clarithromycin on KP-001 Pharmacokinetics in Healthy Adult Participants
CTID: NCT06227832
Phase: Phase 1    Status: Active, not recruiting
Date: 2024-03-27
Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in Egyptians
CTID: NCT06315478
Phase: Phase 4    Status: Completed
Date: 2024-03-18
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
CTID: NCT06216639
Phase:    Status: Enrolling by invitation
Date: 2024-02-09
Evaluate the Effect of Clarithromycin/Rifampicin on the Pharmacokinetics of DA-8010 in Healthy Adults
CTID: NCT05991401
Phase: Phase 1    Status: Completed
Date: 2024-01-25
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia
CTID: NCT04724044
Phase: Phase 3    Status: Completed
Date: 2023-12-12
A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants
CTID: NCT05965570
Phase: Phase 1    Status: Completed
Date: 2023-12-11
Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology
CTID: NCT05742568
Phase: Phase 4    Status: Recruiting
Date: 2023-11-14
Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patients
CTID: NCT04843579
Phase: Phase 2    Status: Terminated
Date: 2023-10-25
A Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral Vonoprazan (TAK-438) 20 mg Compared to Esomeprazole 20 mg Twice Daily in Paticipants With Helicobacter Pylori Infection
CTID: NCT04198363
Phase: Phase 3    Status: Completed
Date: 2023-09-07
A Study of Vonoprazan in Adults With Helicobacter Pylori
CTID: NCT04753437
Phase: Phase 1    Status: Completed
Date: 2023-08-31
The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori
CTID: NCT06004401
Phase: N/A    Status: Not yet recruiting
Date: 2023-08-22
Finding the Optimal Regimen for Mycobacterium Abscessus Treatment
CTID: NCT04310930
Phase: Phase 2/Phase 3    Status: Recruiting
Date: 2023-08-08
Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication
CTID: NCT05049902
Phase: Phase 4    Status: Completed
Date: 2023-07-19
Drug Interaction Study Between Tegoprazan, Bismuth, Amoxicillin and Clarithromycin
CTID: NCT05915871
Phase: Phase 1    Status: Completed
Date: 2023-06-23
Electrophysiological Effects of Potential QT Prolonging Drugs
CTID: NCT05716854
Phase: Phase 1    Status: Completed
Date: 2023-06-22
BiRd vs. Rd as Initial Therapy in Multiple Myeloma
CTID: NCT02516696
Phase: Phase 3    Status: Terminated
Date: 2023-06-05
Recurrence Rate Comparison Between Esomeprazole and Lansoprazole in Eradicating Helicobacter Pylori Infection Among Children
CTID: NCT05861687
Phase: Phase 2/Phase 3    Status: Completed
Date: 2023-05-17
Efficacy of Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests for Helicobacter Pylori Infection
CTID: NCT05718609
Phase: Phase 4    Status: Recruiting
Date: 2023-05-15
CYP3A4 Activity and Mineral Homeostasis
CTID: NCT02019875
PhaseEarly Phase 1    Status: Completed
Date: 2023-04-19
CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections
CTID: NCT03236987
Phase: Phase 3    Status: Recruiting
Date: 2023-03-22
Efficacy and Safety of Dual Therapy as First-line Treatment for Hp Infection
CTID: NCT05419674
Phase: Phase 4    Status: Unknown status
Date: 2023-02-16
High Dose Dual Therapy vs Clarithromycin Triple Therapy for Treatment Naive H Pylori Infection in an Urban Population
CTID: NCT05342532
Phase: Phase 4    Status: Completed
Date: 2023-02-01
Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy
CTID: NCT04697186
Phase: Phase 4    Status: Completed
Date: 2023-01-31
Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication
CTID: NCT05014334
Phase: Phase 4    Status: Completed
Date: 2023-01-31
Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm
CTID: NCT03440112
Phase: Phase 1/Phase 2    Status: Completed
Date: 2023-01-10
A Drug Interaction Study of Clarithromycin and LY3502970 in Healthy Participants
CTID: NCT05469126
Phase: Phase 1    Status: Completed
Date: 2022-11-25
Immunomodulatory Effect of Macrolides in Naturally Occurring Influenza Virus Infections in the Community
CTID: NCT03824847
Phase: Phase 4    Status: Suspended
Date: 2022-11-04
Assessment of Change in CYP3A Activity by Route of Administration Using Metabolic Markers in Healthy Male Volunteers
CTID: NCT03366974
Phase: Phase 1    Status: Completed
Date: 2022-10-27
Evaluation of Metabolic Markers for the Prediction of DDI of Various CYP3A Substrates and Inhibitors
CTID: NCT02975037
Phase: Phase 1    Status: Completed
Date: 2022-10-27
Vonoprazan Hp Dual or Triple Eradication Regimes
CTID: NCT05345210
Phase: Phase 4    Status: Unknown status
Date: 2022-10-20
Perpetrator DDI Potential of Givinostat as Inhibitor and Inducer of CYP3A and P-gp Activity
CTID: NCT05492318
Phase: Phase 1    Status: Completed
Date: 2022-08-08
Efficacies of Hybrid and High-dose Dual Therapies for the First-line Anti-H Pylori Treatment
CTID: NCT05152004
Phase: N/A    Status: Completed
Date: 2022-07-20
S. Aureus Decolonization in HPN Patients.
CTID: NCT03173053
Phase: N/A    Status: Terminated
Date: 2022-05-31
Duration of Antibiotics Treatment With Cefazoli
ANTIBIOTIC THERAPY IN RESPIRATORY TRACT INFECTIONS: AIR.
CTID: null
Phase: Phase 4    Status: Trial now transitioned
Date: 2020-04-03
Prospective randomised trial of first line treatments of Helicobacter pylori infection in Slovenia
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2020-03-09
Shortened Antibiotic Treatment in Community-Acquired Pneumonia: A Nationwide Danish Randomized Controlled Trial
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2019-04-29
An Open Label Study to Assess the Efficacy and Safety of Fixed-Dose
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2019-02-14
Effects of antibiotics on micobiota, pulmonary immune response and incidence of ventilator-associated infections
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2019-01-14
Defining best Management in Adult Chronic RhinOsinusitis
CTID: null
Phase: Phase 4    Status: GB - no longer in EU/EEA
Date: 2018-07-13
Immediate oral, immediate topical or delayed oral antibiotics for acute otitis media with discharge (the Runny Ear STudy: REST)
CTID: null
Phase: Phase 4    Status: Completed
Date: 2018-05-23
CLArithromycin versus AZIthromycin in the treatment of Mycobacterium avium complex pulmonary infections:
CTID: null
Phase: Phase 3    Status: Trial now transitioned
Date: 2017-09-15
A randomized, double-blind, placebo-controlled study of the usefulness of the probiotic 'Lactobacillus reuteri' in the therapy of quadruple eradication of Helicobacter pylori infection in usual clinical practice
CTID: null
Phase: Phase 4    Status: Completed
Date: 2017-04-04
Placebo-kontrollierte, multizentrische, randomisierte, doppelblinde Phase III-Studie zur Verbesserung der gastrointestinalen Verträglichkeit einer per-oralen Antibiotikatherapie durch add-on-Gabe von Lactobacillus rhamnosus GG (InfectoDiarrstop® LGG® Mono Kapseln) bezogen auf die Häufigkeit einer AAD bei Kindern unter 2 Jahren
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2016-11-17
A phase II trial addressing feasibility and activity of clarithromycin +
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2016-08-31
Eradication of H. pylori infection in Belgium: bismuth versus first line therapy
CTID: null
Phase: Phase 4    Status: Completed
Date: 2016-07-13
Biomarker guided antibiotic treatment in Community-Acquired Pneumoni (BIO-CAP)
CTID: null
Phase: Phase 4    Status: Completed
Date: 2016-04-01
Lenalidomide and dexamethasone (Ld) versus Clarithromycin / Lenalidomide [Revlimid®] / Dexamethasone (BiRd) as initial therapy in Multiple Myeloma.
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2015-09-30
Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (COVID-19)
CTID: null
Phase: Phase 4    Status: Trial now transitioned, Temporarily Halted, GB - no longer in EU/EEA, Ongoing
Date: 2015-09-16
A Phase III Randomized, Double Blind, Placebo-controlled, Multicenter, Parallel Group Study to Assess the Efficacy and Safety of Fixed-dose Combination RHB-104 in Subjects with Moderately Active Crohn’s Disease
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2015-08-27
A Phase III Randomized, Double Blind, Placebo-controlled, Multicenter, Parallel Group Study to Assess the Efficacy and Safety of Fixed-dose Combination RHB-104 in Subjects with Moderately to Severely Active Crohn’s Disease
CTID: null
Phase: Phase 3    Status: Completed
Date: 2015-07-24
insulin resistance, obesity and gastrointestinal bacteria
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2015-06-09
A randomized placebo-controlled phase II study of clarithromycin or placebo
CTID: null
Phase: Phase 2    Status: Prematurely Ended
Date: 2014-09-05
A randomized, open-label phase III study of Clarithromycin, Sulfamethoxa-zole/Trimethoprim or observation in combination with standard therapy in patients with newly diagnosed multiple myeloma
CTID: null
Phase: Phase 3    Status: Completed
Date: 2013-01-29
FIRST-LINE ERADICATOR THERAPY OF HELICOBACTER PYLORI INFECTION: OPEN CLINICAL TRIAL, RANDOMIZED, MULTICENTRE, THREE-ARMED, COMPARING THE CLASSICAL TRIPLE THERAPY VERSUS A MODIFIED SEQUENTIAL THERAPY AND A CURRENT THERAPY
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2012-04-02
Individualizing duration of antibiotic therapy in hospitalized patients with community-acquired pneumonia: a non-inferiority, randomized, controlled trial.
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2011-12-20
Helicobacter eradication to prevent ulcer bleeding in aspirin users: a large simple randomised controlled trial
CTID: null
Phase: Phase 4    Status: GB - no longer in EU/EEA
Date: 2011-12-15
Phase II clinical study on the activity of salvage therapy with high doses of oral clarithromycin in patients with extranodal marginal zone relapsed or refractory lymphoma
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2011-12-06
The pharmacokinetic effect of clarithromycin on the AUC0-12h of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients
CTID: null
Phase: Phase 1, Phase 4    Status: Ongoing
Date: 2011-07-27
A prospective single blind randomised controlled study to compare the outcomes of patients with diabetes and clinically non-infected ischaemic and neuropathic foot ulcers treated with and without oral antibiotics
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2011-07-13
A Phase II trial of broad spectrum antibiotic therapy for early stage chronic lymphocytic leukaemia.
CTID: null
Phase: Phase 4    Status: Completed
Date: 2011-03-24
ESTUDIO FASE IV, PROSPECTIVO, ALEATORIZADO Y COMPARATIVO ENTRE LA TERAPIA “SECUENCIAL” Y “CONCOMITANTE” PARA LA ERRADICACIÓN DE Helicobacter pylori EN LA PRÁCTICA CLÍNICA HABITUAL
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2010-09-22
PLEASE Persistent Lyme Empiric Antibiotic Study Europe. A prospective, randomised study comparing two prolonged oral antibiotic strategies after initial intravenous ceftriaxone therapy for patients with symptoms of proven or possible persistent Lyme disease
CTID: null
Phase: Phase 4    Status: Completed
Date: 2010-04-29
Ensayo clínico unicéntrico, simple ciego y aleatorizado de comparación de la eficacia erradicadora de primera línea frente al Helicobacter pylori entre la triple terapia convencional oral con claritromicina, amoxicilina y omeprazol (CAO) durante 10 días frente a triple terapia alternativa oral con levofloxacino, amoxicilina y omeprazol (LAO) durante 10 días
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2008-09-29
A cluster randomised trial of different strategies of antibiotic use to reduce the incidence and consequences of chest infection in acute stroke patients with swallowing problems.
CTID: null
Phase: Phase 4    Status: Completed
Date: 2008-08-13
Efficacy and Safety of Quadruple Therapy by Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Given x 10 days With Omeprazole in Eradication of Helicobacter pylori: A Comparison to Omeprazole, Amoxicillin and Clarithromycin Given x 7 days
CTID: null
Phase: Phase 3    Status: Completed
Date: 2008-03-28
Prospective, Randomized, Double-Blind Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil 600 mg PO, BID for 10 Days Versus Clarithromycin in the Treatment of Community-Acquired Pneumonia”
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2008-01-06
A national, prospective, randomized, open label study to asses the efficacy and safety of IV/PO moxifloxacin vs IV ceftriaxone + IV azithromicin followed by PO amoxicilline/clavulanate and PO claritromycin in subjects with community-acquired pneumonia
CTID: null
Phase: Phase 3    Status: Prematurely Ended
Date: 2007-12-10
Efficacité comparative de l'éradication de H.pylori et d'un inhibiteur de pompe à proton vs. l'abstention thérapeutique sur lésions gastriques induite par l'aspirine à faible dose chez les malades traités au long cours en prévention d'une thrombose coronaire ou vasculaire cérébrale-Aspylori.
CTID: null
Phase: Phase 4    Status: Ongoing
Date: 2007-11-09
Helicobacter pylori Eradication vs Aspirin Toxicity Trial
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2007-09-21
Does adding YF476 to amoxicillin and clarithromycin aid eradication of H. pylori from healthy carriers?
CTID: null
Phase: Phase 2    Status: Completed
Date: 2007-07-13
Helicobacter eradication therapy in Chronic Obstructive Pulmonary Disease: A pilot,randomised, double blinded, placebo controlled trial
CTID: null
Phase: Phase 4    Status: Completed
Date: 2007-06-22
A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED CLINICAL TRIAL OF THE SAFETY AND IMMUNOMODULATORY THERAPY FOR THE MANAGEMENT OF SEPSIS
CTID: null
Phase: Phase 3    Status: Ongoing
Date: 2007-06-05
A Double-Blinded, Randomized, Parallel group, Multi-Centre, Multi-National Comparative Study of the Safety and Efficacy of Cethromycin 300mg QD to Clarithromycin (KLACID®) 250mg BID for the treatment of Community-Acquired Pneumonia (CAP) in Adults
CTID: null
Phase: Phase 3    Status: Completed
Date: 2006-08-24
Prospective, multicenter, randomized, double blind, parallel arm study to evaluate the efficacy and safety of Moxifloxacin 400 mg OD for 7 days versus amoxicillin clavulanate/claritromycin for 10 days in the treatment of Acute Bacterial Rhino Sinusitis
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2005-12-13
Untersuchung über die Empfindlichkeitsveränderungen oraler Mundstreptokokken gegenüber Makrolidantibiotika nach Gabe von AzithromycinSR versus ClarithromycinXL bei freiwilligen gesunden Probanden
CTID: null
Phase: Phase 2    Status: Ongoing
Date: 2005-08-31
Is there a role for Helicobacter pylori eradication in the treatment of laryngopharyngeal reflux? : A double blinded randomised case controlled clinical trial
CTID: null
Phase: Phase 4    Status: Prematurely Ended
Date: 2005-01-06
An Open-label, Randomised, Multicentre, Multi-country Three-arm Study of the Treatment with Finafloxacin 400 mg b.i.d. plus Esomeprazole 40 mg b.i.d. for 14 days versus Finafloxacin 400 mg b.i.d. plus Esomeprazole 40 mg b.i.d. plus Amoxicillin 1000 mg b.i.d. for 10 days versus Clarithromycin 500 mg b.i.d. plus Amoxicillin 1000 mg b.i.d. plus Esomeprazole 40 mg b.i.d. for 10 Days in Patients with Helicobacter pylori infection. Finafloxacin in patients with Helicobacter: The FLASH 2 Study
CTID: null
Phase: Phase 2    Status: Prematurely Ended, Completed
Date:
Long term follow up and comparative study of fecal microbiota after vonoprazan and low-dose amoxicillin dual therapy or vonoprazan-based triple therapy for Helicobacter pylori infection
CTID: UMIN000040025
Phase:    Status: Complete: follow-up continuing
Date: 2020-04-01
Investigation of methods for preventing biofilm formation in peritoneal dialysis-related peritonitis
CTID: UMIN000038500
Phase:    Status: Complete: follow-up complete
Date: 2019-11-11
Open-label randomized comparative study of ceftriaxone vs. ampicillin/sulbactam in adults with mild to moderate community-acquired pneumonia
CTID: UMIN000037464
Phase: Phase IV    Status: Complete: follow-up complete
Date: 2019-07-25
Intermittent versus daily therapy for nodular bronchiectatic Mycobacterium avium complex lung disease (iREC)
CTID: jRCTs031190008
Phase:    Status: Complete
Date: 2019-04-15
The Study on HElicobacter Pylori eradication in patients with HEPatic complications
CTID: UMIN000012196
Phase:    Status: Complete: follow-up complete
Date: 2019-03-31
Antibacterial therapy for severe sarcoid uveitis
CTID: jRCTs031180301
Phase:    Status: Complete
Date: 2019-03-15
Susceptibility based Fourth-line eradication
CTID: jRCTs031180208
Phase:    Status: Complete
Date: 2019-03-07
Therapy with macrolide in severe asthmatic patients with peripheral blood neutrophilia: a non-blinded, crossover trial
CTID: UMIN000034699
Phase:    Status: Pending
Date: 2018-11-02
Berberine containing therapy for initial Helicobacter Pylori eradication
CTID: UMIN000034554
Phase:    Status: Recruiting
Date: 2018-10-20
Efficacy and safety of dual therapy containing vonopranzan and amoxicillin as first line Helicobacter pylori eradication: a randomized, non-inferiority trial
CTID: UMIN000034140
Phase: Phase II,III    Status: Complete: follow-up complete
Date: 2018-09-14
Berberine containing quadruple therapy for initial Helicobacter Pylori eradication
CTID: UMIN000033829
Phase:    Status: Recruiting
Date: 2018-08-20
Japanese AntibaCterial drug maNagemEnt for cardiac Sarcoidosis Trial
CTID: UMIN000025936
Phase:    Status: Complete: follow-up continuing
Date: 2017-02-20
A pilot study of Susceptibility testing based Fourth-line Helicobacter pylori eradication therapy
CTID: UMIN000025765
Phase:    Status: Complete: follow-up complete
Date: 2017-01-22
A randomized controlled trial comparing Vonoprazan, Amoxicillin and Metronidazole triple therapy and Vonoprazan, Amoxicillin and Clarithromycin triple therapy as a first-line eradication of Helicobacter pylori
CTID: UMIN000025773
Phase:    Status: Complete: follow-up complete
Date: 2017-01-22
Establishment of the algorithm for reccurent infant wheezing under 2 years of age
CTID: UMIN000025243
PhaseNot applicable    Status: Complete: follow-up complete
Date: 2017-01-04
Clarithromycin plus intravenous immunoglobulin therapy for Kawasaki disease, a phase 3, multicenter, randomized, double blind, placebo control study.
CTID: UMIN000024311
Phase:    Status: Complete: follow-up complete
Date: 2016-10-06
Phase 2 study of clarithromycin, pomalidomide and dexamethasone(ClaPD) for patients with relapsed or refractory multiple myeloma
CTID: UMIN000024166
Phase: Phase II    Status:
Date: 2016-09-26
Eradication of H. Pylori With the Regimen Individualized Susceptibility of H. Pylori to Clarithromycin Determined by the Mutation of 23S rRNA of H. Pylori
CTID: UMIN000022766
Phase: Phase II    Status: Pending
Date: 2016-07-01
Comparison of vonoprazan-based dual therapy with amoxicillin and the triple therapy with amoxicillin and clarithromycin for H. Pylori Eradication
CTID: UMIN000022922
Phase:    Status: Recruiting
Date: 2016-07-01
Prospective multicenter non-randomized parallel-group comparative study to evaluate the efficacy of P-CAB/AMPC/MNZ 7 day triple therapy as first line eradication of CAM-resistant Helicobacter pylori: superiority study compared to P-CAB/AMPC/CAM, non-inferiority study compared to PPI/AMPC/MNZ, superiority study compared to PPI/AMPC/CAM
CTID: UMIN000022920
Phase:    Status: Complete: follow-up complete
Date: 2016-06-28
The efficacy and safety of Helicobacter pylori eradication therapy using vonoprazan
CTID: UMIN000021824
Phase:    Status: Complete: follow-up complete
Date: 2016-04-07
Prospective multicenter cohort study to evaluate the efficacy and safety of Helicobacter pylori eradication therapy
CTID: UMIN000021604
Phase:    Status: Complete: follow-up complete
Date: 2016-03-25
Investigation of improved Helicobacter pylori eradication rate using Vonoprazan for first-line therapy: large prospective study.
CTID: UMIN000021383
Phase:    Status: Complete: follow-up complete
Date: 2016-03-07
A randomized controlled trial comparing the first-line eradication rate using vonoprazan or PPI for Helicobacter pylori infectious gastritis.
CTID: UMIN000021148
Phase:    Status: Complete: follow-up complete
Date: 2016-02-23
Study of Helicobacter pylori eradication therapy using vonoprazan
CTID: UMIN000019158
Phase:    Status: Complete: follow-up continuing
Date: 2015-10-01
Drug use surveillance of Takecab for 'Supplement to Helicobacter pylori eradication'
CTID: jRCT1080222951
Phase:    Status:
Date: 2015-08-31
A trial to study of treatment with a new PPI for infection of H. pylori with Clarithromycin resistance
CTID: UMIN000018595
Phase:    Status: Complete: follow-up continuing
Date: 2015-08-07
Investigation of the efficacy and safety of high-dose clarithromycin in adult patients with community-acquired pneumonia-multicenter,single-group,open-label study
CTID: UMIN000016277
Phase:    Status: Complete: follow-up complete
Date: 2015-01-20
Study assessing combined therapy with clarithromycin and amoxicillin in childhood acute otitis media
CTID: UMIN000015564
Phase:    Status: Complete: follow-up complete
Date: 2014-11-01
A multicenter, randomized control study to assess the safety and efficacy of IVIG plus clarithromycin, a biofilm modulator for Kawasaki disease.
CTID: UMIN000015437
Phase:    Status: Complete: follow-up complete
Date: 2014-10-15
Comparison of efficacy and safety of levofloxacin-containing versus standard sequential therapy in eradication of Helicobacter pylori infection in Korea
CTID: UMIN000015375
Phase:    Status: Complete: follow-up complete
Date: 2014-10-08
Phase 2 study to evaluate the efficacy and the safety of clarithromycin, lenalidomide and dexamethasone (Personalized BiRd) for patients with relapsed or refractory multiple myeloma
CTID: UMIN000013467
Phase: Phase II    Status: Compllse if(down_display === 'none' || down_display === '') { icon_angle_up.style.display = 'none'; icon_angle_down.style.displa

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