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Description: CM03 is a potent inhibitor of cell growth in PDAC cell lines, and has anticancer activity in PDAC models, with a superior profile compared to gemcitabine, a commonly used therapy. Whole-transcriptome RNA-seq methodology has been used to analyze the effects of this quadruplexbinding small molecule on global gene expression. This has revealed the down-regulation of a large number of genes, rich in putative quadruplex elements and involved in essential pathways of PDAC survival, metastasis, and drug resistance. The changes produced by CM03 represent a global response to the complexity of human PDAC and may be applicable to other currently hard-to-treat cancers.
2023-2024产品目录
产品使用说明书(通用型)
Molecular Formula: C34H44N6O6;
Molecular Weight: 632.762;
Exact Mass: 632.3322;
Related CAS #: 2101208-44-8 (free base) 2101208-52-8 (HCl) 2101208-53-9 (2HCl) 2101208-54-0 (3HCl);
Related CAS#: 2101208-44-8 (free base);
Chemical Name: CM03; CM-03; CM 03.;
InChi Key: 2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone;
InChi Code: KCCGFZWBVFNFGW-UHFFFAOYSA-N;
SMILES: InChI=1S/C34H44N6O6/c41-31-24-5-6-25-29-28(24)26(33(43)39(31)12-3-10-37-15-19-45-20-16-37)23-27(35-7-14-36-8-1-2-9-36)30(29)34(44)40(32(25)42)13-4-11-38-17-21-46-22-18-38/h5-6,23,35H,1-4,7-22H2;
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS