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    CM03
    CM03

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    InvivoChem目录号 #: V18563
    CAS号码 #: 2101208-44-8纯度 ≥98%

    Description: CM03 is a potent inhibitor of cell growth in PDAC cell lines, and has anticancer activity in PDAC models, with a superior profile compared to gemcitabine, a commonly used therapy. Whole-transcriptome RNA-seq methodology has been used to analyze the effects of this quadruplexbinding small molecule on global gene expression. This has revealed the down-regulation of a large number of genes, rich in putative quadruplex elements and involved in essential pathways of PDAC survival, metastasis, and drug resistance. The changes produced by CM03 represent a global response to the complexity of human PDAC and may be applicable to other currently hard-to-treat cancers. 

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    Molecular Formula: C34H44N6O6; 

    Molecular Weight: 632.762; 

    Exact Mass: 632.3322; 

    Related CAS #: 2101208-44-8 (free base)   2101208-52-8 (HCl)   2101208-53-9 (2HCl)   2101208-54-0 (3HCl); 

    Related CAS#: 2101208-44-8 (free base); 

    Chemical Name: CM03; CM-03; CM 03.; 

    InChi Key: 2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone; 

    InChi Code: KCCGFZWBVFNFGW-UHFFFAOYSA-N; 

    SMILES: InChI=1S/C34H44N6O6/c41-31-24-5-6-25-29-28(24)26(33(43)39(31)12-3-10-37-15-19-45-20-16-37)23-27(35-7-14-36-8-1-2-9-36)30(29)34(44)40(32(25)42)13-4-11-38-17-21-46-22-18-38/h5-6,23,35H,1-4,7-22H2; 


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