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    ABT-510 TFA salts
    ABT-510 TFA salts

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    产品仅用于科学研究,不针对患者销售
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    InvivoChem目录号 #: V9987
    CAS号码 #: 251579-55-2纯度 ≥98%

    Description: ABT-510 TFA, the trifluoroacetic acid (TFA) salt form of ABT-510 which is a TSP-1 mimetic drug, is a synthetic peptide composed of nine-amino acids, it acts by mimicking the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). ABT-510 was designed with TSRs as base, displayed anti-angiogenic properties in a phase 1 clinical trial in newly diagnosed glioblastoma.

    References

    1. SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma. Oncotarget. 2017 Sep 12;8(49):85969-85983. 

    2. The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer. Neoplasia. 2010 Mar;12(3):275-83.  

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    Molecular Formula: C46H83N13O11.C2HF3O2

    Molecular Weight: 1108.253; 

    Exact Mass: 1107.626; 

    Synonym: ABT 510; ABT510; ABT-510; 

    Related CAS#: 251579-55-2; 

    IUPAC Condensed: Ac-Sar-Gly-Val-D-aIle-Thr-Nva-Ile-Arg-Pro-NHEt 

    Sequence: GGVXTXIRP 

    IUPAC Name: N-acetyl-sarcosyl-glycyl-L-valyl-D-alloisoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl-L-proline ethylamide

    Chemical Name: (S)-1-((2S,5S,8S,11S,14R,17S)-5,14-di((S)-sec-butyl)-2-(3-guanidinopropyl)-11-((S)-1-hydroxyethyl)-17-isopropyl-24-methyl-4,7,10,13,16,19,22,25-octaoxo-8-propyl-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl)-N-ethylpyrrolidine-2-carboxamide; 

    SMILES: O=C([C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CCC)NC([C@H]([C@@H](O)C)NC([C@@H]([C@@H](C)CC)NC([C@H](C(C)C)NC(CNC(CN(C)C(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)NCC; 

    Storage information: 

    Powder form: -80°C for 2 years; -20°C for 1 year (seal the vial well, protect from moisture)

    Solution form: -80°C for 6 months; -20°C for 1 month (seal the vial well, protect from moisture)


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    Guidelines for Dissolving Peptides:

    Identifying a suitable solvent or formulation for and/or determining the solubility of a given peptide is a highly challenging task as improper solubilization may lead to loss of peptides or even failure of an experiment. The steps illustrated below provides you with  a  method  to perform a  solubility  test for determining  the  best solvent  for  a  synthetic peptide.  It is best to test it by dissolving a minute amount of peptide, rather than the entire sample. As a general rule, peptides should first be dissolved in distilled/sterile water, in particular peptides of fewer than five amino acid residues. For  individual peptides,  conditions  are  chosen  for optimum  solubility  based  on  the given  peptide sequence.


    In general, hydrophilic peptides dissolve well in water (H2O), but hydrophobic peptides may not be soluble in water.

    Guidelines for Peptide Solubility and Storage:

    1.  Calculate the length of the peptide.

    2.  Calculate the overall charge of the peptide following the instructions in the table below:


    Amino acids and abbreviationsCharge Value Assigned
    Acidic amino acidsAsp (D), Glu (E), C-terminal -COOH-1
    Basic amino acidsArg (R), Lys (K), His (H), N-terminal -NH2+1
    Neutral amino acidsGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

    3.  How to choose solvents for dissolving peptides based on their overall charges and hydrophilicity/hydrophobicity:


    Overall charge of peptidesProtocol for dissolving peptides
    Negatively charged peptides (<0)1.  First, try to dissolve the peptides in water;
    2.  If insoluble in water, add a small amount of NH4OH (e.g.<50 μL);
    3.  If still insoluble, add a small amount of DMSO (e.g. 50-100 μL) to aid the solubilization of the peptide.
    Positively charged peptides (>0)1.  First, try to dissolve the peptides in water;
    2.  If insoluble in water, try to dissolve the peptide in 10%-30% acetic acid solution (10%-30% acetic acid in water, w/w);
    3.  If still insoluble, try to dissolve the peptide in a small amount of DMSO (e.g. 50-100 μL).
    Zero charged peptides(=0)1.  First, try to dissolve the peptide in organic solvents (e.g. acetonitrile, methanol);
    2.  For highly  hydrophobic peptides, try to dissolve in a small amount of DMSO, followed by dilution of the solution with water to the desired concentrations.





    These protocols are for reference only. InvivoChem does not independently validate these methods.

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