Tie-2

• Angiogenesis | 血管生成
  5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
• Anti-infection | 抗感染
  Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
• Apoptosis | 凋亡
  Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
• Autophagy | 自噬
  Autophagy LRRK2 Mitophagy OGA ULK
• Cell Cycle | 细胞周期
  Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
• Cytoskeletal Signaling | 细胞骨架
  Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
• DNA Damage | DNA损伤
  ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
• Endocrinology & Hormones | 内分泌/荷尔蒙
  5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
• Epigenetics | 表观遗传
  AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
• GPCR & G Protein | G蛋白偶联/G蛋白
  5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

• Immunology/Inflammation | 免疫及炎症
  FAP Mucin Interleukin Related CD22 ALCAM/CD166 CD19 CD2 CD20 CD3 CD38 CD73 CD80 AKR1C Antibiotics AP-1 Arginase Aryl Hydrocarbon Receptor CD28 cGAS Complement System COX FLAP Galectin Glucocorticoid Receptor IFN Immunology & Inflammation related Interleukins IRAK LTR MALT MIF MyD88 NFAT NLR NLRP3 NO Synthase Nrf2 PD-1 PD-L1 PGE synthase PKR Prostaglandin Receptor Reactive Oxygen Species ROS SIK SPHK STING TBK1 Thrombopoietin Receptor TLR
• JAK/STAT 信号通路
  EGFR JAK Pim STAT
• MAPK 信号通路
  ERK JNK KLF MAP3K MAP4K MEK Mixed Lineage Kinase MK2 MNK p38 MAPK Raf RSK
• Metabolic Enzyme/Protease | 代谢酶/蛋白酶
  11β-HSD 5 alpha Reductase ACE Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adiponectin Receptor ALDH Aldose Reductase Aminopeptidase ATGL ATP Citrate Lyase Carbonic Anhydrase Cathepsin Ceramidase Cytochrome P450 DGK DHODH Dihydroorotate Dehydrogenase Dipeptidyl Peptidase Dopamine β-hydroxylase Drug Metabolite E1 E2 E3 Enzyme Elastase Endogenous Metabolite Epoxide Hydrolase Factor Xa Farnesyl Transferase FASN FBPase FTO FXR Glucokinase Glucosidase Glutathione Peroxidase GSNOR Gutathione S-transferase Hexokinase HIF HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMGCR IDH IDO Lactate Dehydrogenase Liposome LXR MAGL Mineralocorticoid Receptor Metabolism|代谢 MMP MTHFD NADPH Oxidase NEDD8-activating Enzyme Neprilysin PAI-1 PDI PHGDH Phosphatase Phosphodiesterase(PDE) Phospholipase PREP Procollagen C Proteinase Proteasome Pyruvate Kinase RAR RXR Reactive Oxygen Species Renin REV-ERB ROR SCD Ser Thr Protease Thrombin TrxR Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase Amylases Glycobiology Enzymes Disease Research Enzymes Nuclease 17β-HSD
• Metabolism | 代谢
  Acetyl-CoA Carboxylase AChR ACSS2 Acyltransferase AdipoR AhR Aldose Reductase ATP-citrate lyase CAR Carbohydrate Metabolism Carbonic Anhydrase Casein Kinase CETP cGAS CPSase CPT Decarboxylase Dehydrogenase DHFR FAAH FABP Factor Xa Fatty Acid Synthase Ferroptosis FXR Glucosylceramide Synthase GLUT Glutathione HMG-CoA Reductase HSP Hydroxylase IAP IDO Lipase Lipoxygenase MAO Mitochondrial Metabolism Mitochondrial pyruvate carrier NAMPT OXPHOS P450 (e.g. CYP) PCSK9 PDE Peroxidases PGC-1α Phosphatase Phospholipase Phosphorylase PKM PPAR PRMT Prostaglandin Receptor Retinoid Receptor ROR SCD Serine hydrolase Serine threonin kinase SGK SHIP Thioredoxin Reductase THR Thrombopoietin Receptor Transferase Vitamin Xanthine Oxidase
• Methylation | 甲基化
  NNMT
• Microbiology | 微生物学
  Anti-infection | 抗感染 Antibiotics Antiviral Bacterial CCR CMV COVID-19 Fungal HIV Protease HSV Influenza Virus Integrase Parasite Reverse Transcriptase RSV β-lactamase
• Neuronal Signaling | 神经信号通路
  5-HT Receptor AAK1 AChR Receptor Adenosine Kinase Adrenergic Receptor BACE BChE Beta Amyloid Beta-secretase Calcium Channel CaMK ChE COX Dopamine Receptor Dopamine Transporter GABA Receptor Glucosylceramide Synthase GluR Histamine Receptor Imidazoline Receptor Monoamine Oxidase NMDAR Notch Opioid Receptor OX Receptor P2 Receptor P2Y Receptor Serotonin Transporter Sigma Receptor Tau Protein Transthyretin (TTR) α-synuclein γ-secretase
• New Products | 新产品
  NEW4 NEW1 NEW2 NEW3
• NF-kB 信号通路
  IκB IKK Keap1-Nrf2 NF-κB NOD1 ROS MALT1
• Others | 其他产品
  Isotope-Labeled Compounds Amino Acid Derivatives Biochemical Assay Reagents Fluorescent Dye gp120 CD4 LOX-1 Others Others 10 Others 2 Others 3 Others 4 Others 5 Others 6 Others 7 Others 8 Others 9 Others 11 Others 12 Others 13 Others 14 Others 15 Others 16 Drug Derivative Drug Intermediate Drug Isomer
• PI3K/Akt/mTOR 信号通路
  Akt AMPK ATM ATR DNA-PK GSK- 3 MELK mTOR NUDIX PDHK PDK-1 PDPK1 PI3K PI4K PIKfyve PP2A PTEN S6 kinase
• Proteases | 蛋白酶
  3C-Like Protease Acyltransferase Cysteine Protease DPP-4 Gamma-secretase Glutaminase HCV Protease HIV Protease MMP Neprilysin Proteasome Serine Protease Thrombin Tyrosinase Protease
• Protein Tyrosine Kinase | 蛋白激酶
  ALK Axl Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-MET CSF-1R DDR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 HER-2 HER2 IFG-1R Insulin Receptor Itk Mertk PDGFR Pyk2 RET ROS Kinase SHP2 Src Syk TAM Receptor Tie-2 Trk receptor VEGFR Tie IGF-1R
• Signaling Pathways 信号通路
  Methylation | 甲基化 Protein Tyrosine Kinase | 蛋白激酶 JAK/STAT 信号通路 NF-kB 信号通路 Proteases | 蛋白酶 Unfolded Protein Response | 未折叠蛋白反应 Vitamin D Related/Nuclear Receptor | 维生素D相关/核受体 New Products | 新产品 Cell Cycle | 细胞周期 DNA Damage | DNA损伤 Cytoskeletal Signaling | 细胞骨架 Endocrinology & Hormones | 内分泌/荷尔蒙 GPCR & G Protein | G蛋白偶联/G蛋白 Neuronal Signaling | 神经信号通路 Transmembrane | 跨膜转运 Microbiology | 微生物学 Stem Cells/Wnt 信号通路 Ubiquitin | 泛素 TGF-beta / Smad 信号通路 Angiogenesis | 血管生成 Anti-infection | 抗感染 Apoptosis | 凋亡 Immunology/Inflammation | 免疫及炎症 Metabolic Enzyme/Protease | 代谢酶/蛋白酶 Metabolism | 代谢 Epigenetics | 表观遗传 ADC Related | 抗体偶联药物相关 Autophagy | 自噬 MAPK 信号通路 Others | 其他产品 PI3K/Akt/mTOR 信号通路
• Stem Cells/Wnt 信号通路
  Casein Kinase GSK-3 Hedgehog（Smoothened） ROCK Hippo (MST) Oct PKA Porcupine SFRP Smo STAT Stemness kinase TGF-beta/Smad 信号通路 Wnt（beta）-catenin YAP β-catenin Wnt
• TGF-beta / Smad 信号通路
  MT Receptor PKC ROCK TGF-beta(Smad) TGF-β Receptor
• Transmembrane | 跨膜转运
  Adrenergic Receptor Amino Acid Transporter Apical Sodium-Dependent Bile Acid Transporter Aquaporin ATP Synthase ATPase BCRP Calcium Channel Calmodulin CD markers CFTR Chloride Channel CRAC Channel CRM1 EAAT GABA Receptor GlyT HCN Channel iGluR Interleukins Monoamine Transporter Monocarboxylate Transporter Monocarboxylate Transporter2 MTP Na+Ca2+ Exchanger Na+HCO3- Cotransporter Na+K+ ATPase nAChR NHE NKCC OAT P-gp P2 Receptor P2X Receptor Piezo Channel Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1 VDAC MCT
• Ubiquitin | 泛素
  DUB E1 Activating E2 conjugating E3 Ligase p97 SUMO
• Unfolded Protein Response | 未折叠蛋白反应
  Deubiquitinase Eukaryotic Initiation Factor IRE1 PDI
• Vitamin D Related/Nuclear Receptor | 维生素D相关/核受体
  Androgen Receptor ERR Glucocorticoid Receptor Progesterone Receptor Thyroid Hormone Receptor VD VDR